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RV
Not CommonVerified
Rosehip Vitamin C
Rosa canina
Vitamin C source for sailors and winter colds in European tradition
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Rosehip (Rosa canina) is a plant source rich in bioactive compounds, particularly ascorbic acid, with demonstrated antioxidant and anti-inflammatory properties [PMID:35335334, PMID:31138475].
Background
Rosa canina is a perennial shrub producing reddish pseudo-fruits used across the pharmaceutical, cosmetic, and food industries [PMID:37605366, PMID:38332573].
Traditional uses
Rose hips have been traditionally used to treat kidney stones, gastroenteric ailments, hypertension, and respiratory problems such as cough, cold, and bronchitis [PMID:30317989]. They have also been used in folk medicine for various types of arthritis, including rheumatoid and osteoarthritis [PMID:27816506].
Active compounds
Major active components include ascorbic acid (Vitamin C), flavonoids (such as quercetin, rutin, and kaempferol), tannins, anthocyanins, phenolic acids (notably ellagic acid), carotenoids (lycopene, beta-carotene, lutein), and organic acids (citric, malic, tartaric) [PMID:35897912, PMID:34829066, PMID:22083314, PMID:38684952, PMID:38999097].
Mechanism of action
Anti-inflammatory effects are mediated by inhibiting NF-κB signaling and pro-inflammatory enzymes (e.g., COX-2, MMPs), decreasing inflammatory cytokine and chemokine production (TNF-α, IL-1β, IL-6), and lowering C-reactive protein levels [PMID:34348637, PMID:27816506]. It also exerts potent antioxidant radical scavenging effects [PMID:31138475]. In rodent models, it may antagonize PPAR gamma activity to exert antiobesity effects [PMID:38332573].
Clinical evidence
Evidence AOsteoarthritis
A meta-analysis of three RCTs showed that Rosa canina powder reduced pain scores compared to placebo [PMID:18407528].
Evidence ACardiovascular and Metabolic Health
A systematic review of RCTs indicated mixed effects on LDL-C and blood glucose levels, with some studies showing significant benefits [PMID:38283449].
Evidence DHair Growth
Topical application of rosehip seed oil in C57BL/6 mice stimulated hair growth by inducing the transition of follicles from telogen to anagen phase [PMID:38188083].
Evidence DObesity and Diabetes
In high-fat diet-fed mice, R. canina flesh reduced body-weight gain and improved hyperglycemia and insulin resistance [PMID:38332573]. In spontaneously diabetic Torii rats, hot-water extract improved glucose tolerance and preserved pancreatic beta-cell function [PMID:28182280].
Safety & adverse effects
An expert panel concluded that 12 Rosa canina-derived ingredients are safe for use in cosmetics when formulated to be non-irritating and non-sensitizing [PMID:35531605].
Evidence summary
Evidence for pain reduction in osteoarthritis is supported by a meta-analysis of RCTs, though some reviews note a scarcity of high-quality studies for other applications like scar treatment. Much of the metabolic and hair-growth evidence is currently limited to animal models.
PubMed sources
1.PMID: 37605366 (2024) — Rosehip extract and wound healing: A review. · Journal of cosmetic dermatology
2.PMID: 35897912 (2022) — Bioactive Compounds in Rosehip (Rosa canina) Powder with Encapsulating Agents. · Molecules (Basel, Switzerland)
3.PMID: 18407528 (2008) — Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?--a meta-analysis of randomized controlled trials. · Osteoarthritis and cartilage
4.PMID: 36838668 (2023) — Juice Powders from Rosehip (Rosa canina L.): Physical, Chemical, and Antiglycation Properties. · Molecules (Basel, Switzerland)
5.PMID: 38188083 (2023) — Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 34829066 (2021) — Valorization of Rose Hip (Rosa canina) Puree Co-Product in Enriched Corn Extrudates. · Foods (Basel, Switzerland)
7.PMID: 31138475 (2019) — Rosa canina - Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis - A systematic review. · Phytomedicine : international journal of phytotherapy and phytopharmacology
8.PMID: 38283449 (2023) — Effects of Daily Intake of Rosehip Extract on Low-Density Lipoprotein Cholesterol and Blood Glucose Levels: A Systematic Review. · Cureus
9.PMID: 30317989 (2018) — Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review. · Current pharmaceutical design
10.PMID: 34348637 (2021) — Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules. · Current molecular pharmacology
11.PMID: 38332573 (2024) — The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice. · Molecular nutrition & food research
12.PMID: 27816506 (2016) — The genus Rosa and arthritis: Overview on pharmacological perspectives. · Pharmacological research
13.PMID: 39766568 (2024) — An In Vitro Evaluation of Robin's Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent-Comparison to Rosehip and Black Rosehip. · Antibiotics (Basel, Switzerland)
14.PMID: 35335334 (2022) — In Vitro Bioaccessibility of Bioactive Compounds from Rosehip-Enriched Corn Extrudates. · Molecules (Basel, Switzerland)
15.PMID: 22083314 (2012) — Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells. · Journal of the science of food and agriculture
16.PMID: 28182280 (2017) — Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats. · Journal of the science of food and agriculture
17.PMID: 18384191 (2008) — A systematic review on the Rosa canina effect and efficacy profiles. · Phytotherapy research : PTR
18.PMID: 37232954 (2023) — Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract. · Gels (Basel, Switzerland)
19.PMID: 36987001 (2023) — Changes in Pomological and Physical Parameters in Rosehips during Ripening. · Plants (Basel, Switzerland)
20.PMID: 37687310 (2023) — Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes. · Plants (Basel, Switzerland)
21.PMID: 39660068 (2024) — How do roses build failure-resistant anchoring tools? · PNAS nexus
22.PMID: 37110778 (2023) — Bioactive Compounds and Antioxidant Activity in the Fruit of Rosehip (Rosa canina L. and Rosa rubiginosa L.). · Molecules (Basel, Switzerland)
23.PMID: 38999097 (2024) — Molecular and Phytochemical Characteristics of Flower Color and Scent Compounds in Dog Rose (Rosa canina L.). · Molecules (Basel, Switzerland)
24.PMID: 39795198 (2025) — Valorization of Rosehip (Rosa canina L.) Pomace Using Unconventional Carbohydrate Carriers for Beverage Obtainment. · Molecules (Basel, Switzerland)
25.PMID: 40479219 (2022) — Functional Compounds and Antioxidant Activity of Rosa Species Grown In Turkey. · Erwerbs-Obstbau
26.PMID: 36290672 (2022) — Rosehip (Rosa canina L.) Meal as a Natural Antioxidant on Lipid and Protein Quality and Shelf-Life of Polyunsaturated Fatty Acids Enriched Eggs. · Antioxidants (Basel, Switzerland)
27.PMID: 35531605 (2022) — Safety Assessment of Rosa canina-derived Ingredients as Used in Cosmetics. · International journal of toxicology
28.PMID: 38684952 (2024) — Screening and classification of rosehip (Rosa canina L.) genotypes based on horticultural characteristics. · BMC plant biology