PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Leaf extracts (15 µg/ml) significantly inhibited ADP-stimulated platelet aggregation by 38-55% and decreased surface membrane expression of activated GPIIbIIIa receptor by 21% in whole blood [PMID:26836594]
Aqueous and ethanolic extracts of leaves and stems showed antibacterial activity against S. aureus and Staphylococcus epidermidis, with ethanolic leaf extract (LEtOH) showing a MIC of 0.16 ± 0.40-1.56 ± 0.23 mg/mL [PMID:40725002]
Leaf extracts inhibited cell viability in a concentration-dependent manner; the ethyl acetate fraction at 250 µg/mL decreased viability below 66% [PMID:28101119]
Rubus caesius is a component of the Algan Hemostatic Agent (AHA), a multi-herbal extract used to reduce bleeding time in a rat tail hemorrhage model [PMID:33107963]
Evidence summary
PubMed sources
- 1.PMID: 36234716 (2022) — Polyphenolic Characterization, Antioxidant, Antihyaluronidase and Antimicrobial Activity of Young Leaves and Stem Extracts from Rubus caesius L. · Molecules (Basel, Switzerland)
- 2.PMID: 26836594 (2016) — The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. · Platelets
- 3.PMID: 40725002 (2025) — Rubus caesius L. (European Dewberry) Extracts as a Novel Therapeutic Strategy Against MRSA Strains. · International journal of molecular sciences
- 4.PMID: 25034034 (2014) — CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus. · Cellular & molecular biology letters
- 5.PMID: 41182101