PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Oral administration of ethanol extract in rabbits significantly reduced fasting glucose levels (57.3%), total cholesterol, and LDL cholesterol, while increasing HDL cholesterol [PMID:30533432]
In vitro, leaf extracts at 10 mg/ml killed 100% of trophozoites and cysts after 72 hours [PMID:32321413]
Seed extracts possess cancer-inhibiting properties; when combined with 5-fluorouracil, they trigger apoptosis via PI3K/Akt inhibition [PMID:36918141, 38918540]
Hydroethanolic and ethanolic leaf extracts exhibited significant anti-T. evansi activity, inducing necrosis rates of 64.6% and 63.7% respectively [PMID:41948979]
Hydroalcoholic leaf extracts demonstrated anti-Candida and antioxidant activities [PMID:31278700]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 35361815 (2022) — Molecular evidence for natural hybridization between Rumex crispus and R. obtusifolius (Polygonaceae) in Korea. · Scientific reports
- 2.PMID: 16332339 (2005) — Spatial variation in Bacillus thuringiensis/cereus populations within the phyllosphere of broad-leaved dock (Rumex obtusifolius) and surrounding habitats. · FEMS microbiology ecology
- 3.PMID: 32321413 (2021) — Evaluation of the Effects of Rumex obtusifolius Seed and Leaf Extracts Against Acanthamoeba: An in vitro Study. · Infectious disorders drug targets
- 4.PMID: 35318884 (2022) — Effects of indirect plant-plant interaction via root exudate on growth and leaf chemical contents in Rumex obtusifolius. · Plant signaling & behavior
- 5.PMID: 37898617