This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Syzygium polyanthum, known as Salam leaf or Indonesian bay leaf, is a plant used in Southeast Asian cuisines and traditional medicine for managing diabetes and hypertension [PMID:26389944, 34761082].
Background
Syzygium polyanthum (S. polyanthum) is a plant belonging to the Myrtaceae family, widely used in Indonesian and Malaysian cuisines [PMID:26389944, 42280237]. It is often sold or mistaken as a substitute for the true bay leaf (Laurus nobilis) due to similarities in aroma and morphology [PMID:28249302].
Traditional uses
Traditionally used in Indonesia and Malaysia to treat diabetes and hypertension [PMID:26389944, 29333036, 34761082]. For diabetes, traditional use involves boiling leaves until the water is reduced to half volume and taking the decoction 1-2 times daily [PMID:34508803].
Active compounds
Identified compounds include β-ocimene (a key volatile compound) [PMID:35966267], squalene [PMID:36296407], and acylbenzenes such as 12-oxo-12-(2,3,5-trihydroxy-4-methylphenyl)dodecanoic acid [PMID:32879232]. Other isolated constituents include phloroglucinol derivatives (anthuminoate and anthuminone), pheophorbides [PMID:22978223], and various trihydroxy-methylphenyl derivatives [PMID:29332193].
Mechanism of action
Potential mechanisms include the inhibition of α-glucosidase [PMID:34508803], inhibition of HMG-CoA Reductase to reduce cholesterol [PMID:31008409], and inhibition of protein tyrosine phosphatase 1B (PTP1B) [PMID:32879232]. It may also induce vasorelaxation via autonomic receptors and nitric oxide [PMID:29333036] and reduce inflammatory markers such as C-reactive protein (CRP), myeloperoxidase (MPO), TNF-α, and ADAM17 [PMID:31601063, 33603264].
Clinical evidence
Evidence BType 2 Diabetes Mellitus
A preliminary clinical trial using an aqueous extract mixture of S. polyanthum and Andrographis paniculata in patients treated with metformin examined benefits in lowering blood glucose [PMID:30668423].
Evidence DHyperglycemia (Animal Model)
Methanol extract and specific chloroform fractions significantly lowered blood glucose levels in streptozotocin-induced diabetic rats [PMID:26389944, 36296407].
Evidence DHypertension (Animal Model)
Aqueous and methanolic extracts induced dose-dependent hypotension in both normotensive and spontaneously hypertensive rats [PMID:29333036, 24454508].
Evidence DMyocardial Infarction (Animal Model)
Extract administration reduced levels of CRP, MPO, TNF-α, and ADAM17, and supported angiogenesis by increasing VEGF and CD31 expression [PMID:31601063, 33603264, 32567295].
Evidence DMelanogenesis (In Vitro)
Methanol extract decreased extracellular melanin formation by 20-80% and inhibited tyrosinase activity in B16 melanoma cells [PMID:29332193].
Safety & adverse effects
A 28-day subacute toxicity study in rats using methanolic extract (up to 2000 mg/kg) showed no significant effects on body weight, feed intake, oestrous cycle, or behavior, with only statistically insignificant variations in AST levels [PMID:34367515].
Dosage & administration
Traditional preparation involves boiling leaves until the water is reduced to half volume, taken 1-2 times daily [PMID:34508803]. Consult a healthcare provider.
Evidence summary
Evidence is primarily based on in vitro studies and animal models (Level D), with one preliminary clinical trial (Level B) regarding adjunctive use in diabetes. Most findings support antidiabetic, antihypertensive, and anti-inflammatory activities.
PubMed sources
1.PMID: 35966267 (2022) — The Identification of β-Ocimene Biosynthetic Pathway Through Mevalonate Acid (MVA) and 1-Deoxy-D-Xylulose 5-Phosphate (DXP) Pathways Using Crude Enzyme Extracts in Indonesian Bay Leaf/Salam Leaf (Syzygium polyanthum). · Tropical life sciences research
2.PMID: 26389944 (2015) — Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats. · Nutrients
3.PMID: 29332193 (2018) — Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract. · Journal of natural medicines
4.PMID: 31601063 (2020) — The effect of bay leaf extract Syzygium polyanthum (Wight) Walp. on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model of myocardial infarction. · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
5.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity.
· Heliyon
6.PMID: 34508803 (2022) — α-glucosidase inhibitors from Syzygium polyanthum (Wight) Walp leaves as revealed by metabolomics and in silico approaches. · Journal of ethnopharmacology
7.PMID: 32567295 (2020) — The effect of bay leaf extract (Syzygium polyanthum) on vascular endothelial growth factor (VEGF) and CD31 (PECAM-1) expression in acute coronary syndrome. · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
8.PMID: 34367515 (2021) — Subacute Toxicity Evaluation of Methanolic Extract of Syzygium polyanthum in Rats. · Tropical life sciences research
9.PMID: 36296407 (2022) — Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of Syzygium polyanthum (Wight.)'s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model. · Molecules (Basel, Switzerland)
10.PMID: 30668423 (2019) — Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes. · Phytomedicine : international journal of phytotherapy and phytopharmacology
11.PMID: 33603264 (2020) — Syzygium Polyanthum Reduced TNF-α and ADAM17 Protein Expression in Myocardial Infarction Rat Model. · Medical archives (Sarajevo, Bosnia and Herzegovina)
12.PMID: 31040564 (2019) — Antibacterial and cytotoxic activities of the Syzygium polyanthum leaf extract from Malaysia. · Veterinary world
13.PMID: 21440883 (2011) — Biological activity and phytochemical analysis of three Indonesian medicinal plants, Murraya koenigii, Syzygium polyanthum and Zingiber purpurea. · Journal of acupuncture and meridian studies
14.PMID: 38125456 (2023) — Antibacterial potential of silver nanoparticles (SP-AgNPs) synthesized from Syzygium polyanthum (Wight) Walp. against selected foodborne pathogens. · Heliyon
15.PMID: 22978223 (2012) — Two new phloroglucinol derivatives and five photosensitizing pheophorbides from Syzygium polyanthum leaves (Salam). · Natural product communications
16.PMID: 29410966 (2017) — Antibacterial Activity of Ethanolic Extract of Syzygium polyanthum L. (Salam) Leaves against Foodborne Pathogens and Application as Food Sanitizer. · BioMed research international
17.PMID: 29333036 (2017) — Autonomic Receptors and Nitric-Oxide Involvements in Mediating Vasorelaxation Effect Induced by Syzygium polyanthum Leaves Extract. · Pharmacognosy research
18.PMID: 32879232 (2020) — Screening of Indonesian Edible Plants for Bioactive Constituents and a New Protein Tyrosine Phosphatase 1B Inhibitory Acylbenzene Derivative from Leaves of Indonesian Syzygium polyanthum. · Chemical & pharmaceutical bulletin
19.PMID: 24454508 (2013) — Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats. · Evidence-based complementary and alternative medicine : eCAM
20.PMID: 39050386 (2024) — Antidiabetic Activity, Phytochemical Analysis, and Acute Oral Toxicity Test of Combined Ethanolic Extract of Syzygium polyanthum and Muntingia calabura Leaves. · TheScientificWorldJournal
21.PMID: 34761082 (2021) — LCMS dataset on compounds in Syzygium polyanthum (Wight) Walp. leaves variant from the East coast of Peninsular Malaysia. · Data in brief
22.PMID: 42280237 (2026) — Solvent-Dependent GC-MS Fingerprinting of Lipophilic Constituents in Syzygium polyanthum Leaves: A Baseline Study for Future Greener Extraction Optimization. · Molecules (Basel, Switzerland)
23.PMID: 28249302 (2017) — Which Bay Leaf is in Your Spice Rack? - A Quality Control Study. · Planta medica