PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A preliminary clinical trial using an aqueous extract mixture of S. polyanthum and Andrographis paniculata in patients treated with metformin examined benefits in lowering blood glucose [PMID:30668423].
Methanol extract and specific chloroform fractions significantly lowered blood glucose levels in streptozotocin-induced diabetic rats [PMID:26389944, 36296407].
Aqueous and methanolic extracts induced dose-dependent hypotension in both normotensive and spontaneously hypertensive rats [PMID:29333036, 24454508].
Extract administration reduced levels of CRP, MPO, TNF-α, and ADAM17, and supported angiogenesis by increasing VEGF and CD31 expression [PMID:31601063, 33603264, 32567295].
Methanol extract decreased extracellular melanin formation by 20-80% and inhibited tyrosinase activity in B16 melanoma cells [PMID:29332193].
Safety & adverse effects
Dosage & administration
Evidence summary
PubMed sources
- 1.PMID: 35966267 (2022) — The Identification of β-Ocimene Biosynthetic Pathway Through Mevalonate Acid (MVA) and 1-Deoxy-D-Xylulose 5-Phosphate (DXP) Pathways Using Crude Enzyme Extracts in Indonesian Bay Leaf/Salam Leaf (Syzygium polyanthum). · Tropical life sciences research
- 2.PMID: 26389944 (2015) — Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats. · Nutrients
- 3.PMID: 29332193 (2018) — Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract. · Journal of natural medicines
- 4.PMID: 31601063 (2020) — The effect of bay leaf extract Syzygium polyanthum (Wight) Walp. on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model of myocardial infarction. · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
- 5.PMID: 31008409