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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Salvadora persica, commonly known as Miswak, is an evergreen shrub or tree used traditionally as a natural toothbrush for oral hygiene [PMID:22228963, PMID:24979958]. It is recognized for its antimicrobial, antiplaque, and antigingivitis properties [PMID:24979958, PMID:25935172].
Background
Salvadora persica (also known as Arak, Peelu, or kharijal) is a large, evergreen shrub or tree found in dry and arid regions of India and widely used across Western Asia and Muslim populations [PMID:22228963, PMID:29196134, PMID:35944735]. It belongs to the Salvadoraceae family [PMID:35652125, PMID:25737893].
Traditional uses
For centuries, the twigs, roots, and stems have been used as chewing sticks (miswak) for tooth cleaning [PMID:22228963, PMID:25935172]. It has also been used in folk medicine for food, cosmetics, fuel, and as a general medicine [PMID:34400870].
Active compounds
The plant contains bioactive compounds including flavonoids, glycosides, sterols, terpenes, carbohydrates, alkaloids, and organic sulfur-containing compounds [PMID:34400870]. Benzyl isothiocyanate is identified as the major active antibacterial metabolite in the roots [PMID:31516317, PMID:30766432].
Mechanism of action
Miswak removes bacterial plaque through a combination of mechanical cleansing action and the release of active chemical constituents [PMID:27095914, PMID:38098022].
Clinical evidence
Evidence ADental Plaque and Gingivitis
Miswak is effective in reducing plaque and gingivitis, with some studies suggesting its mechanical and chemical efficacy is equal to or greater than conventional toothbrushes [PMID:25935172, PMID:35944735, PMID:39517363].
Evidence APlaque and Cariogenic Bacteria
Salvadora persica mouthrinses are used to reduce plaque and cariogenic bacteria, compared to chlorhexidine or placebo [PMID:31029127].
Evidence COral Pathogens
The plant exhibits antibacterial, antifungal, and antiviral properties against various oral pathogens, including Enterococcus faecalis [PMID:25935172, PMID:34987597].
Evidence DOral Tissue Healing
In vivo studies in rats suggest that miswak extracts may promote wound healing in oral tissues [PMID:37817781].
Safety & adverse effects
While evidence supports its clinical effectiveness in plaque control, the effects of miswak on periodontal health remain inconclusive, and misuse has been noted [PMID:34861857, PMID:36639461].
Dosage & administration
Administered as chewing sticks, mouthwash, toothpaste, essential oil, aqueous or ethanol extracts, probiotic spray, or dental varnish [PMID:32565699]. No PubMed data available. Consult a healthcare provider.
Evidence summary
The evidence for Salvadora persica in oral health is strongest regarding plaque and gingivitis reduction, supported by systematic reviews and RCTs. Other pharmacological claims (e.g., antidiabetic, antitumor) are mentioned in reviews but lack the same level of clinical trial data in the provided abstracts.
PubMed sources
1.PMID: 36639461 (2023) — Miswak misuse. · British dental journal
4.PMID: 32565699 (2020) — Miswak and oral health: An evidence-based review. · Saudi journal of biological sciences
5.PMID: 29196134 (2018) — A review of the traditional and modern uses of Salvadora persica L. (Miswak): Toothbrush tree of Prophet Muhammad. · Journal of ethnopharmacology
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 35944735 (2022) — The effectiveness of miswak (Salvadora persica L. and Azadirachta indica A.Juss.) practices in reducing plaque and gingivitis among adults: A systematic review and meta-analysis. · Journal of ethnopharmacology
7.PMID: 35652125 (2022) — Salvadora persica's Biological Properties and Applications in Different Dental Specialties: A Narrative Review. · Evidence-based complementary and alternative medicine : eCAM
9.PMID: 25935172 (2015) — A review of the therapeutic effects of using miswak (Salvadora Persica) on oral health. · Saudi medical journal
10.PMID: 33946353 (2021) — Salvadora persica: Nature's Gift for Periodontal Health. · Antioxidants (Basel, Switzerland)
11.PMID: 40475057 (2025) — Antibiofilm Properties of Miswak (Salvadora persica) Compared to Conventional Oral Health Measures: A Systematic Review. · Scientifica
12.PMID: 34861857 (2021) — Clinical benefits and adverse effects of siwak (S. persica) use on periodontal health: a scoping review of literature. · BMC oral health
13.PMID: 31029127 (2019) — The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of chlorhexidine: a systematic review and meta-analysis. · BMC oral health
14.PMID: 27095914 (2016) — Role of Salvadora persica chewing stick (miswak): A natural toothbrush for holistic oral health. · European journal of dentistry
15.PMID: 34400870 (2021) — Salvadora persica L.: Toothbrush tree with health benefits and industrial applications - An updated evidence-based review. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
16.PMID: 24019798 (2013) — Efficacy of miswak on oral pathogens. · Dental research journal
17.PMID: 31516317 (2019) — Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots "Siwak". · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
18.PMID: 25737893 (2013) — Miswak in oral cavity - An update. · Journal of oral biology and craniofacial research
19.PMID: 38684974 (2024) — Effect of Salvadora persica on resin-dentin bond stability. · BMC oral health
20.PMID: 38774172 (2024) — Phytochemical Composition and Antimicrobial Efficacy of Salvadora persica Root Extracts Against Carbapenem-Resistant Acinetobacter baumannii. · Cureus
21.PMID: 30766432 (2019) — Effect of hydroxylated solvents on the active constituents of Salvadora persica root "Siwak". · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
22.PMID: 40579279 (2025) — Integration of various forms of Salvadora Persica « Siwak » into dental composites: A pilot in vitro study. · Dental materials : official publication of the Academy of Dental Materials
23.PMID: 39517363 (2024) — Comparative Effectiveness of Miswak and Toothbrushing on Dental Plaque and Gingivitis: A Randomized Controlled Trial. · Healthcare (Basel, Switzerland)
24.PMID: 38098022 (2023) — Effectiveness of Salvadora persica toothbrush and Salvadora persica chewing stick in plaque and gingivitis control: a randomized control trial. · BMC complementary medicine and therapies
25.PMID: 38844768 (2024) — Synergistic effect of Salvadora persica and chitosan nanoparticles against oropharyngeal microorganisms. · Scientific reports
26.PMID: 34987597 (2021) — GC/MS Profiling and Ex Vivo Antibacterial Activity of Salvadora persica (Siwak) against Enterococcus faecalis as Intracanal Medicament. · Evidence-based complementary and alternative medicine : eCAM
27.PMID: 37128650 (2023) — Anti-fungal efficacy of Miswak Extract (Salvadora Persica) and commercial cleaner against Candida albicans on heat cured polymethylmethacrylate denture base. · Journal of applied biomaterials & functional materials
28.PMID: 30117638 (2018) — Chemical effects of chewing sticks made of Salvadora persica. · International journal of dental hygiene
29.PMID: 37817781 (2023) — The effect of Salvadora persica ethanolic extract on oral tissue healing in rats: An in vivo study. · The Saudi dental journal
30.PMID: 17038057 (2006) — Siwak as a oral hygiene aid in patients with fixed orthodontic appliances. · International journal of dental hygiene