PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 12 PubMed articles · model: gemma4:31b
Summary
Background
Active compounds
Mechanism of action
Clinical evidence
Petroleum ether extract (SLPE) significantly delayed paralysis and extended longevity in transgenic C. elegans (CL4176) [PMID:39337674]
Five saleucane compounds significantly inhibited nitric oxide (NO) production in BV-2 cells, with IC50 values (3.29 to 6.65 microM) superior to minocycline hydrochloride [PMID:40288666]
Essential oil demonstrated inhibitory activity of BuChE with an IC50 of 32.60 microg/mL [PMID:34207496]
Leucansalvialin F2 and leucansalvialin J showed moderate neuroprotective effects in PC12 cells [PMID:29625143]
A butanoyl 3,4-dihydrosalviandulin E analogue (semisynthetic) showed strong antitrypanosomal activity against Trypanosoma brucei brucei [PMID:24388808]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 29435878 (2006) — A novel diterpenoid with a rearranged neoclerodane skeleton from Salvia leucantha CAV. · Journal of natural medicines
- 2.PMID: 29625143 (2018) — Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav. · Fitoterapia
- 3.PMID: 39337674 (2024) — Components in SLPE Alleviate AD Model Nematodes by Up-Regulating Gene gst-5. · International journal of molecular sciences
- 4.PMID: 34790877 (2021) — Characterization of the complete chloroplast genome of Salvia leucantha (Lamiaceae). · Mitochondrial DNA. Part B, Resources
- 5.PMID: 40288666 (2025) — Saleucanes A-J, structurally diverse neo-clerodane diterpenoids from Salvia leucantha with anti-neuroinflammatory activity via TLR4/MYD88/NF-κB pathway.