PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ethyl acetate extract attenuates UC by inhibiting the PI3K-AKT/NF-κB/STAT3 pathway [PMID:37717310]; combined with Sophora japonica, it inhibits pathological angiogenesis and inflammation [PMID:40518692].
Aqueous extracts suppress growth and metastasis by inhibiting the Wnt/β-catenin pathway [PMID:34785413] and enhance 5-fluorouracil sensitivity via Ras/MEK/ERK and PI3K/Akt pathways [PMID:37484409].
Standardized extract decreased lipid accumulation and ROS production in adipocytes and ameliorated hepatic steatosis and fibrosis in mice [PMID:37107257, PMID:37686810].
Ferulic acid (a component of S. officinalis) promotes megakaryocyte maturation and platelet production [PMID:40571222].
Root extract and ziyuglycoside I inhibit HYBID-mediated hyaluronan degradation [PMID:30485450].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 37717310 (2023) — Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT/NF-κB/ STAT3 pathway uncovered by single-cell RNA sequencing. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 29433389 (2018) — Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review. · The American journal of Chinese medicine
- 3.PMID: 40571222 (2025) — Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia. · Biochemical pharmacology
- 4.PMID: 40607420 (2025) — The processed Sanguisorba officinalis L. triterpenoids prevent colon cancer through the TNF-α/NF-κB signaling pathway, combined with network pharmacology, molecular simulation dynamics and experimental verification. · Frontiers in immunology
- 5.PMID: 34616302