PubMed-compiled information sheet
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Compiled from 5 PubMed articles · model: gemma4:31b
Summary
Scadoxus puniceus is a South African medicinal plant used in traditional herbal tonics and for the treatment of neurological disorders [PMID:29226479, PMID:24330357].
Background
Scadoxus puniceus (Amaryllidaceae) is a highly traded medicinal plant from South Africa [PMID:29226479].
Traditional uses
It is used as a component of a traditional herbal tonic prescribed for several ailments [PMID:29226479] and is used traditionally to treat neurological disorders [PMID:24330357].
Active compounds
Metabolite profiling shows a predominance of hydroxycinnamic acids (69.5%) over hydroxybenzoic acids (30.5%), with chlorogenic acid being the most abundant hydroxycinnamic acid (49.6%) [PMID:29226479]. The presence of sinapic, gallic, and m-hydroxybenzoic acids has also been reported [PMID:29226479].
Mechanism of action
Pure compounds from S. puniceus exhibit acetylcholinesterase inhibitory activity [PMID:29226479].
Clinical evidence
Evidence DAcetylcholinesterase Inhibition
Ethyl acetate root extracts of S. puniceus showed a low IC(50) value of 0.000 3 mg/mL for acetylcholinesterase inhibition in vitro [PMID:22014742].
Evidence DNeuroprotection (In Vitro)
In SH-SY5Y neuroblastoma cells, the methanol extract of S. puniceus was found to be the most cytotoxic among tested plants, with an LC50 of 20.75 ± 1.47 µg/ml [PMID:24330357].
Safety & adverse effects
In vitro studies using SH-SY5Y neuroblastoma cells indicate that the methanol extract of S. puniceus is cytotoxic, with an LC50 of 20.75 ± 1.47 µg/ml [PMID:24330357].
Evidence summary
The available evidence is limited to in vitro laboratory studies (D) focusing on chemical profiling, acetylcholinesterase inhibition, and cytotoxicity; there are no clinical trials or human data provided.
PubMed sources
- 1.PMID: 29226479 (2018) — Metabolite profiling and isolation of biologically active compounds from Scadoxus puniceus, a highly traded South African medicinal plant. · Phytotherapy research : PTR
- 2.PMID: 22014742 (2011) — In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa. · Asian Pacific journal of tropical medicine
- 3.PMID: 24330357 (2013) — In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells. · BMC complementary and alternative medicine