PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 17 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Hydromethanolic extract (4 mg/mL) significantly reduced cell viability by 78.3% after 72 hours [PMID:35235421].
Aqueous extract (100 mg/kg) ameliorated hepatic steatosis and metabolic syndrome by reducing lipid accumulation, oxidative stress, and inflammation in rats on a hyperfatty diet [PMID:34335826].
Aqueous-methanol extract (100 mg/kg daily for 28 days) significantly amended fasting blood glucose levels in streptozotocin-induced diabetic rats [PMID:23052826].
Crude extract lowered glucose efflux by 39.4%-42.6% and ameliorated inflammatory markers in CaCo-2 and RAW 264.7 cell lines [PMID:38107090].
Ethanolic extract and taraxasteryl acetate exhibited antispasmodic and spasmogenic effects, suggesting possible lithuretic activity [PMID:9434612, PMID:17252378].
Evidence summary
PubMed sources
- 1.PMID: 35235421 (2022) — Effects of Golden Thistle (Scolymus hispanicus L.) on Cytotoxic Activity: Cell Cycle Arrest and Apoptotic Properties on the CaCo-2 Cell Line. · Journal of medicinal food
- 2.PMID: 38107090 (2023) — Golden thistle (Scolymus hispanicus L.) hydromethanolic extracts ameliorated glucose absorption and inflammatory markers in vitro. · Food science & nutrition
- 3.PMID: 34335826 (2021) — Scolymus hispanicus (Golden Thistle) Ameliorates Hepatic Steatosis and Metabolic Syndrome by Reducing Lipid Accumulation, Oxidative Stress, and Inflammation in Rats under Hyperfatty Diet. · Evidence-based complementary and alternative medicine : eCAM
- 4.PMID: 37375965 (2023) — Determination of Caffeoylquinic Acids Content by UHPLC in Scolymus hispanicus Extracts Obtained through Ultrasound-Assisted Extraction. · Plants (Basel, Switzerland)
- 5.PMID: 37111846