PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Potential for restoring Tfh/Tfr balance and alleviating oxidative stress [PMID:38879922].
Potential in inhibiting metastasis, specifically through $\beta$-sitosterol affecting cell viability and migration [PMID:40651298].
Triterpenoids significantly inhibited proliferation, migration, and invasion [PMID:40076586].
Water-extracted P. vulgaris significantly alleviated the growth of ectopic endometrial lesions in mice [PMID:35444541].
Aqueous extract alleviated injury by inhibiting oxidative stress and ferroptosis [PMID:40089199].
Seed oil improved fatigue-like behaviors and reduced tumor growth by attenuating hypothalamic inflammation [PMID:40993108].
Evidence summary
PubMed sources
- 1.PMID: 40651298 (2025) — An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 40215815 (2025) — Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 3.PMID: 38879922 (2024) — Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 4.PMID: 25078822 (2013) — Chemical constituents of Prunella vulgaris. · Journal of environmental sciences (China)
- 5.PMID: 33538676