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PubMed · <i>Adansonia digitata</i> L. (Baobab) Bioactive Compounds, Biological Activities, and the Potential Effect on Glycemia: A Narrative Review. (2023)
PubMed · Adansonia digitata L. fruit shell extract alleviates lead-induced neurotoxicity in mice via modulation of oxidative stress and a possible chelating activity. (2022)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Adansonia digitata is an African tree valued for its high nutritional content and traditional medicinal properties [PMID:38957190, PMID:37432337].
Background
The baobab (Adansonia digitata L.) is a long-lived, multipurpose tree endemic to the arid and semi-arid regions of sub-Saharan Africa [PMID:39396056, PMID:32533325]. It is integral to rural livelihoods and is used for food, income, and medicine [PMID:39054350, PMID:38058453].
Traditional uses
Traditional uses include the treatment of fever, diarrhea, malaria, cough, dysentery, microbial infections, and cardiovascular disorders [PMID:38957190, PMID:37630364]. It has also been used for hydration, as an antipyretic, antiparasitic, antitussive, and sudorific agent [PMID:37432337].
Active compounds
Bioactive compounds include phenols, flavonoids, proanthocyanins, tannins, catechins, carotenoids [PMID:37432337], hydroxycinnamic acid glycosides, iridoid glycosides, and phenylethanoid glycosides [PMID:28784541]. Seed oils contain N-acylserotonins, specifically N-lignocerylserotonin [PMID:34450265]. The fruit pulp is rich in vitamin C, pectin, fibers, and minerals including calcium, magnesium, potassium, phosphorus, zinc, iron, and copper [PMID:38957190].
Mechanism of action
Baobab polyphenols have demonstrated binding affinity to HMG-CoA reductase and pancreatic lipase in silico, suggesting a potential mechanism for antihyperlipidemic activity [PMID:37630364]. Extracts exhibit antioxidant, cell-protective, and anti-inflammatory activities [PMID:38957190].
Clinical evidence
Evidence BPostprandial Glycemia
Administration of 250 mL baobab aqueous extract significantly lowered the glycemia incremental area under the curve and glucose maximum concentration compared to a control group [PMID:35057579].
Evidence BStarch Digestion and Glycemic Response
Baobab fruit extract reduced starch digestion in vitro and reduced the glycemic response in humans [PMID:24176228].
Evidence BSatiety
Consumption of a smoothie containing 15 g of baobab extract reduced subjective measures of hunger compared to a control smoothie [PMID:28413912].
Safety & adverse effects
No specific adverse effects are listed; however, safety concerns have been raised regarding microbial contamination and aflatoxins in processed baobab products from informal processors [PMID:35252436].
Pregnancy & lactation
Consumption of 40 g of baobab pulp covers 84% to over 100% of the Recommended Daily Intake (RDI) of vitamin C for pregnant women (19-30 years) [PMID:19093269].
Evidence summary
Evidence consists primarily of narrative reviews and small-scale randomized controlled trials (B) focusing on glycemic response and satiety, as well as in vitro and in silico studies (D) regarding lipid metabolism and antioxidant properties.
PubMed sources
1.PMID: 38957190 (2023) — The Potential Uses of Baobab Tree's Medicinal Effects in Dentistry: A Literature Review. · Cureus
2.PMID: 37432337 (2023) — Adansonia digitata L. (Baobab) Bioactive Compounds, Biological Activities, and the Potential Effect on Glycemia: A Narrative Review. · Nutrients
3.PMID: 39054350 (2024) — Mapping every adult baobab (Adansonia digitata L.) across the Sahel and relationships to rural livelihoods. · Nature ecology & evolution
4.PMID: 39396056 (2024) — Chromosome-level baobab genome illuminates its evolutionary trajectory and environmental adaptation. · Nature communications
5.PMID: 38058453 (2023) — Population structure and phenological attributes of Adansonia digitata L. (baobab) in Northwestern lowland area of Ethiopia.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 24176228 (2013) — The polyphenol-rich baobab fruit (Adansonia digitata L.) reduces starch digestion and glycemic response in humans. · Nutrition research (New York, N.Y.)
7.PMID: 37630364 (2023) — Potential Effect of Baobab's Polyphenols as Antihyperlipidemic Agents: In Silico Study. · Molecules (Basel, Switzerland)
8.PMID: 32533325 (2020) — The Baobab (Adansonia digitata L.) in Southern Kenya-A Study on Status, Distribution, Use and Importance in Taita-Taveta County. · Environmental management
9.PMID: 35057579 (2022) — Adansonia digitata L. (Baobab Fruit) Effect on Postprandial Glycemia in Healthy Adults: A Randomized Controlled Trial. · Nutrients
10.PMID: 28413912 (2017) — The acute effects of baobab fruit ( Adansonia digitata) on satiety in healthy adults. · Nutrition and health
11.PMID: 28784541 (2017) — Profiling hydroxycinnamic acid glycosides, iridoid glycosides, and phenylethanoid glycosides in baobab fruit pulp (Adansonia digitata). · Food research international (Ottawa, Ont.)
12.PMID: 35252436 (2022) — Microbial Contamination and Occurrence of Aflatoxins in Processed Baobab Products in Kenya. · International journal of food science
13.PMID: 34450265 (2021) — Acylserotonins - a new class of plant lipids with antioxidant activity and potential pharmacological applications. · Biochimica et biophysica acta. Molecular and cell biology of lipids
14.PMID: 19093269 (2009) — Baobab food products: a review on their composition and nutritional value. · Critical reviews in food science and nutrition