Shankhpushpi Morning Glory (Evolvulus alsinoides): Benefits, Dosage, Safety & Evidence

Frequently asked questions

How does Shankhpushpi (Evolvulus alsinoides) work as a nootropic?

Shankhpushpi (Evolvulus alsinoides) is believed to support cognitive function through multiple pathways. The herb contains alkaloids, flavonoids, and evolvine, which may modulate neurotransmitter systems, particularly affecting acetylcholine and GABA activity. These compounds appear to have neuroprotective and antioxidant properties that may reduce oxidative stress in neural tissues. Traditional Ayurvedic texts classify it as a Medhya Rasayana (brain tonic) that enhances memory and concentration. However, evidence is limited (Level C), and the precise mechanism requires further research to fully understand how it exerts its cognitive-enhancing effects.

Does Shankhpushpi interact with any medications?

Yes, Shankhpushpi (Evolvulus alsinoides) has potential interactions with central nervous system (CNS) medications. Due to its sedative properties, it may potentiate the effects of sleep medications, tranquilizers, and other sedatives, leading to excessive drowsiness. It may also interact with antidepressants, anti-anxiety medications, and anticonvulsants by affecting GABA and other neurotransmitter pathways. If you are taking any CNS-active medications, consult a qualified healthcare provider before using Shankhpushpi. Always disclose all herbal supplements to your healthcare provider to prevent adverse interactions.

What is the recommended dosage for Shankhpushpi powder?

The typical adult dosage for Shankhpushpi (Evolvulus alsinoides) is 250–500 mg of powdered herb taken twice daily. Alternatively, 2–3 grams of dried herb can be prepared as a tea or decoction. Traditional Ayurvedic practice often divides doses between morning and evening administration. Dosage may vary based on the specific formulation and condition being addressed. Start with lower doses to assess tolerance. Clinical evidence for optimal dosing is limited (Level C), so following traditional guidelines or consulting an Ayurvedic practitioner is recommended. Do not exceed recommended amounts without professional guidance.

Is Shankhpushpi safe to take during pregnancy?

No, Shankhpushpi (Evolvulus alsinoides) is contraindicated during pregnancy. The herb contains alkaloids and other compounds that may affect the nervous system and potentially stimulate uterine contractions. Its sedative properties may pose risks to fetal development. There is insufficient safety data for use during breastfeeding as well. Women who are pregnant, planning to become pregnant, or nursing should avoid Shankhpushpi entirely. If you have taken this herb and discover you are pregnant, consult your healthcare provider promptly.

What is Shankhpushpi used for in Ayurveda?

In Ayurveda, Shankhpushpi (Evolvulus alsinoides) is classified as a Medhya Rasayana, or brain tonic, used primarily for memory enhancement, anxiety relief, and nervous exhaustion. It is traditionally prescribed to improve concentration, support learning, and promote mental clarity. The herb is also used to address insomnia due to its mild sedative properties. Some regional Ayurvedic traditions use Evolvulus alsinoides as an alternative source of Shankhpushpi for cognitive support. While animal studies suggest potential nootropic and anxiolytic benefits, human clinical evidence remains limited (Level C).

PubMed-compiled information sheet

This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.

Compiled from 30 PubMed articles · model: gemma4:31b

Summary

Evolvulus alsinoides, known as Shankhpushpi, is a medicinal plant used in Ayurvedic and Unani medicine primarily as a brain tonic to enhance memory and treat neurological disorders [PMID:38250531, 19912732].

Background

Evolvulus alsinoides is a medicinal shrub in the Convolvulaceae family [PMID:38250531, 39357200]. Although used in ancient Indian medicine, it is an American species that was likely introduced to the region in the 1500s or 1600s [PMID:18384986].

Traditional uses

It is traditionally used in India and other countries for neurological disorders including amnesia, as a brain tonic, and for ailments such as asthma, epilepsy, and cardiovascular disorders [PMID:38250531, 38159824].

Active compounds

The plant contains scopoletin (a furanocoumarin), caffeic acid, chlorogenic acid, beta-carotene, and various alkaloids, flavonoids, and phenols including quercetin [PMID:21369458, 38882856, 23662279, 23554763]. Other identified components include evolvulic acids A, B, and C, as well as kaempferol glycosides [PMID:32131634, 17473466].

Mechanism of action

The herb demonstrates antioxidant activity by modulating oxidative alterations in the brain and blood plasma [PMID:19748554, 25480513]. Scopoletin shows binding affinities with ERAP1, SCN3A, and COMT [PMID:38883392], while caffeic acid shows binding affinity with molecules in the insulin signaling cascade [PMID:38882856]. It also inhibits alpha-amylase and alpha-glucosidase [PMID:38882856, 32345272].

Clinical evidence

Evidence BPrimary Hypertension

A randomized controlled trial compared a hydro-alcoholic extract (630 mg daily) to ramipril (5 mg daily) for the treatment of hypertension [PMID:38159824].

Evidence DAmnesia (Animal Model)

Methanolic extract showed nootropic activity in mice with scopolamine-induced amnesia, significantly affecting time spent in maze zones [PMID:38250536, 31049081].

Evidence DWound Healing

The plant exhibits wound healing activity, with alkaloid-enriched ointments promoting dermal wound contraction in rats [PMID:30705787, 27267555].

Evidence DDiabetes (In Vitro)

Aqueous extracts demonstrate antidiabetic potential through the inhibition of alpha-amylase and alpha-glucosidase [PMID:38882856, 32345272].

Safety & adverse effects

In vivo toxicity studies in Swiss albino mice using ethanolic extracts (up to 2000 mg/kg) were conducted to assess acute and sub-acute toxicity [PMID:31049083]. Methanolic extracts triggered apoptosis in human hepatoma HepG2 cells in a concentration-dependent manner [PMID:30456198].

Evidence summary

The evidence consists primarily of preclinical animal models (D), in vitro studies (D), and reviews (C), with one randomized controlled trial (B) investigating antihypertensive effects. Most cognitive and antidiabetic claims are based on animal or laboratory data.

PubMed sources

1.PMID: 38250531 (2023) — Biochemical analysis of methanolic extract from Evolvulus alsinoides. · Bioinformation
2.PMID: 19912732 (2009) — An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
3.PMID: 38250536 (2023) — Nootropic activity of methanolic extract from Evolvulus alsinoides Linn. in mice with scopolamine-induced amnesia. · Bioinformation
4.PMID: 18384986 (2008) — Evolvulus alsinoides (Convolvulaceae): an American herb in the Old World. · Journal of ethnopharmacology
5.PMID: 30705787 (2019) — Wound Healing Activity of Plants from the Convolvulaceae Family. · Advances in wound care

Shankhpushpi Morning Glory

Sources & Citations

Calculate a safe dose of Shankhpushpi Morning Glory