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PubMed · Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects. (2024)
PubMed · Effect of Massa Medicata Fermentata on the intestinal flora of rats with functional dyspepsia. (2023)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Massa Medicata Fermentata (Shen Qu) is a traditional fermented Chinese medicine used primarily to treat digestive disorders and metabolic issues [PMID:36529285, PMID:41670224].
Background
Massa Medicata Fermentata (MMF), also known as Shenqu, is a naturally fermented product and traditional Chinese medicine [PMID:39456523, PMID:30235872]. It is produced through the fermentation of materials such as wheat bran and flour, often involving a complex community of bacteria (e.g., Bacillus, Staphylococcus) and fungi (e.g., Aspergillus, Rhizopus) [PMID:33350238, PMID:39849789, PMID:36527339].
Traditional uses
It is widely used in traditional medicine to treat indigestion, vomiting, diarrhea, flatulence, and to increase stomach activity [PMID:30235872, PMID:36529285, PMID:39456523]. It is also used as a component in formulas for obese women with infertility [PMID:36273747].
Active compounds
MMF contains acidic polysaccharides (SMMFAP and CMMFAP) [PMID:38176512], arabinoxylans [PMID:37884242], and various phenolic compounds including free phenolic acids, methoxylated flavonoids, and flavonoid C-glycosides [PMID:41670224]. Specific isolated compounds include a benzochroman and galactosyl acylglycerols [PMID:30235872]. During fermentation, ingredients such as amygdalin, benzaldehyde, and rutin are gradually degraded [PMID:32455219].
Mechanism of action
MMF exhibits anti-inflammatory and antioxidant effects by activating the NRF2-HO-1 pathway and inhibiting MAPK and NF-κB [PMID:39456523]. It may modulate the intestinal microbiota, influence the secretion of cytokines (e.g., IL-6, TNF-α), and regulate the TLR5/TRIF/ERK1/2 signaling pathway in the colonic mucosa [PMID:41552721, PMID:36505059]. It also demonstrates the ability to inhibit enzymes such as trypsin, α-amylase, and α-glucosidase [PMID:36570240].
Clinical evidence
Evidence DFunctional Dyspepsia
MMF administration in rats improved gastric emptying rates and modulated intestinal flora [PMID:36529285, PMID:38495103]
Evidence DIrritable Bowel Syndrome (IBS-D)
In rat models, MMF reduced visceral hypersensitivity and modulated pathogenic flagellated bacteria and TLR5 expression [PMID:36505059, PMID:41552721]
Evidence DHyperlipidemia/Obesity
MMF showed hypolipidemic effects in hyperlipidemia model rats [PMID:38621881] and suppressed BMI and total cholesterol in zebrafish [PMID:39456523]. A herbal composition containing MMF inhibited lipid accumulation in 3T3-L1 cells and regulated obesity in OLETF rats [PMID:26068433]
Evidence DSpleen Deficiency Constipation
MMF intervention in mice increased fecal water content and body weight while mediating intestinal microbiota and serum peptides [PMID:40115071, PMID:39844840]
Evidence DAlcoholic Liver Disease
MMF may prevent alcoholic liver disease by targeting AKT1, TNF, TP53, IL6, and CASP3 in mouse models [PMID:38299285]
Evidence D
Evidence summary
The current evidence is based primarily on in vitro studies and animal models (rats, mice, zebrafish, and piglets), indicating strong anti-inflammatory, antioxidant, and gastro-protective properties. There are no human clinical trials provided in the source abstracts.
PubMed sources
1.PMID: 36273747 (2023) — Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo. · Journal of ethnopharmacology
2.PMID: 39187876 (2024) — Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy. · Journal of nanobiotechnology
3.PMID: 36529285 (2023) — Effect of Massa Medicata Fermentata on the intestinal flora of rats with functional dyspepsia. · Microbial pathogenesis
4.PMID: 41552721 (2025) — The effect of Massa Medicata Fermentata on the cytokine secretion of colonic mucosa and visceral sensitivity in rats with IBS-D. · Frontiers in cellular and infection microbiology
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Iron-doped carbon dots derived from MML (including Shenqu) alleviated RA by inhibiting neutrophil NETosis and autophagy in mice [PMID:40393979]
Evidence DUlcerative Colitis
Carbon dots derived from MML (including Shenqu) alleviated UC by suppressing inflammation and oxidative stress in an oral administration model [PMID:39187876]
(2024)
— Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects.
· Antioxidants (Basel, Switzerland)
6.PMID: 38621881 (2024) — [Research on mechanism of hypolipidemic effect of Massa Medicata Fermentata based on metabolomics]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
7.PMID: 38176512 (2024) — Structure and properties of acidic polysaccharides isolated from Massa Medicata Fermentata: Neuroprotective and antioxidant activity. · International journal of biological macromolecules
8.PMID: 30397767 (2018) — Probiotics-fermented Massa Medicata Fermentata ameliorates weaning stress in piglets related to improving intestinal homeostasis. · Applied microbiology and biotechnology
9.PMID: 40115071 (2025) — Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. · Frontiers in cellular and infection microbiology
10.PMID: 32455219 (2020) — Biostudy on Traditional Chinese Medicine Massa Medicata Fermentata. · ACS omega
11.PMID: 36527339 (2023) — Processing Mechanism of Massa Medicata Fermentata Based on the Correlation Analysis of Strains, Chemical Compositions and Anti-Inflammatory Activity. · Chemistry & biodiversity
12.PMID: 38495103 (2024) — The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia. · Frontiers in pharmacology
13.PMID: 33350238 (2020) — [Investigation of microbial community involved in fermentation of Massa Medicata Fermentata]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
14.PMID: 37884242 (2023) — Isolation, characterization, trypsin inhibition, liver protective and antioxidant activities of arabinoxylan from Massa Medicata Fermentata and its processed products. · International journal of biological macromolecules
15.PMID: 36570240 (2022) — Comparison of Physicochemical and Bioactive Properties of Polysaccharides from Massa Medicata Fermentata and Its Processed Products. · ACS omega
17.PMID: 38211996 (2023) — [Variations of glucose content in Massa Medicata Fermentata during processing based on quantitative proton nuclear magnetic resonance]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
18.PMID: 32980836 (2020) — Mechanism of Chinese Medicinal-Medicated Leaven for Preventing and Treating Gastrointestinal Tract Diseases. · Digestion
19.PMID: 25775788 (2014) — [Fungal composition in massa medicata fermentata based on culture dependent method and independent PCR-SSCP technique]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
20.PMID: 41670224 (2026) — Fermentation-Driven Changes in Phenolic Compounds of Massa Medicata Fermentata. · Biomedical chromatography : BMC
21.PMID: 35570342 (2022) — [The making method of Shen Qu in Qi Min Yao Shu]. · Zhonghua yi shi za zhi (Beijing, China : 1980)
22.PMID: 30235872 (2018) — Isolation and Identification of Benzochroman and Acylglycerols from Massa Medicata Fermentata and Their Inhibitory Effects on LPS-Stimulated Cytokine Production in Bone Marrow-Derived Dendritic Cells. · Molecules (Basel, Switzerland)
23.PMID: 41734551 (2026) — Mechanism underlying the digestion-enhancing effect of apricot kernel during Massa Medicata Fermentata fermentation. · Food chemistry
24.PMID: 40332618 (2025) — A new strategy for the fermentation of Massa Medicata Fermentata by combining multiple strains of fermentation and their fermentation mechanisms. · Biotechnology letters
25.PMID: 26068433 (2015) — Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats. · Journal of ethnopharmacology
26.PMID: 38299285 (2025) — Exploring the Potential Role of Massa Medicata Fermentata in Alcoholic Liver Injury Disease Based on Network Pharmacology and Animal Experiments. · Combinatorial chemistry & high throughput screening
27.PMID: 39849789 (2025) — The role of apricot kernels in shaping the microbial community composition during Massa Medicata Fermentata fermentation. · Food research international (Ottawa, Ont.)
28.PMID: 39844840 (2024) — Study on the effects of Massa Medicata Fermentata with different formulations on the intestinal microbiota and enzyme activities in mice with spleen deficiency constipation. · Frontiers in cellular and infection microbiology
29.PMID: 23126189 (2012) — [Influence of different processing techniques of massa medicata fermentata on their amylase activity]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
30.PMID: 36505059 (2022) — Effects of Massa Medicata Fermentata on the intestinal pathogenic flagella bacteria and visceral hypersensitivity in rats with irritable bowel syndrome. · Frontiers in physiology