PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Leaf extracts are classified as 'super-antioxidants' with activity comparable to ascorbic acid [PMID:36500458].
Extracts show antibacterial activity against various pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA) [PMID:36500458, PMID:23441048, PMID:26417316].
In mice with castor oil-induced diarrhea, fruit extract (250 mg/kg) showed 87.7% inhibition and delayed the onset of episodes [PMID:34316484]; another study noted significant reduction in stool count at 250 and 500 mg/kg [PMID:37096224].
Fruit extract revealed a significant peripheral analgesic effect in acetic acid-induced writhing models in mice [PMID:36060147].
Fruit extract significantly reduced blood clotting time in a dose-dependent manner (25, 50, and 100 mg/ml) [PMID:37096224].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 29435876 (2006) — Flavonoids from Sonneratia caseolaris. · Journal of natural medicines
- 2.PMID: 23441048 (2012) — Bactericidal Activity of Methanol Extracts of Crabapple Mangrove Tree (Sonneratia caseolaris Linn.) Against Multi-Drug Resistant Pathogens. · Indian journal of pharmaceutical sciences
- 3.PMID: 29684603 (2018) — Protective effect of apple mangrove Sonneratia caseolaris extract in Edwardsiella tarda-infected African catfish, Clarias gariepinus. · Fish & shellfish immunology
- 4.PMID: 36500458 (2022) — Indonesian Mangrove Sonneratia caseolaris Leaves Ethanol Extract Is a Potential Super Antioxidant and Anti Methicillin-Resistant Staphylococcus aureus Drug. · Molecules (Basel, Switzerland)
- 5.PMID: 41149581