PubMed-compiled information sheet
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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Artemisia abrotanum, also known as southern wormwood, is a medicinal plant used in European and Asian medicine with demonstrated antioxidant and anti-inflammatory properties [PMID:33923002, PMID:39199260].
Background
Artemisia abrotanum L. is a plant species significant in the history of medicine across Central Asia, Asia Minor, and South-East and Central Europe [PMID:33923002]. Raw materials are typically obtained as Abrotani herba and Abrotani folium [PMID:33923002].
Traditional uses
In traditional European medicine, it has been used for liver and biliary tract diseases, parasitic diseases in children, and as an antipyretic medication [PMID:33923002].
Active compounds
The plant contains polyphenolic compounds, including phenolic acids such as chlorogenic acid, ellagic acid, caffeic acid, and rosmarinic acid, as well as flavones, specifically rutin and umbelliferone [PMID:36984794].
Mechanism of action
Ethanol extracts of A. abrotanum exhibit antioxidant and anti-inflammatory activities, involving the measurement of nuclear factor-kB-p65 (NfkB-p65) and NLRP3 inflammasome activation [PMID:39199260]. Additionally, polyphenolic-rich extracts show inhibitory activity against α-amylase and α-glucosidase, which may reduce glucose absorption [PMID:36984794].
Clinical evidence
Evidence DInflammation
Ethanol extracts demonstrated anti-inflammatory activity in acute rat inflammation induced by turpentine oil [PMID:39199260]
Evidence DType 2 Diabetes Management
Polyphenolic-rich extracts exhibit inhibitory α-amylase and α-glucosidase activities, suggesting potential application in diabetes management [PMID:36984794]
Evidence CGeneral Biological Activity
Evidence suggests antibacterial, antifungal, antioxidant, anticancer, and antiallergic properties [PMID:33923002]
Evidence summary
The current evidence is primarily based on a review of traditional use and in vitro or animal-based phytochemical studies; there are no human clinical trials provided in the source material.
PubMed sources
- 1.PMID: 39199260 (2024) — Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum. · Antioxidants (Basel, Switzerland)
- 2.PMID: 36984794 (2023) — Artemisia abrotanum and Symphytum officinale Polyphenolic Compounds-Rich Extracts with Potential Application in Diabetes Management. · Metabolites
- 3.PMID: 33923002 (2021) — Artemisia abrotanum L. (Southern Wormwood)-History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications. · Molecules (Basel, Switzerland)