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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Stachys lavandulifolia, commonly known as Mountain Tea, is a perennial flowering plant of the Lamiaceae family used in traditional medicine for its anxiolytic, analgesic, and anti-inflammatory properties [PMID:38189318, PMID:40899416].
Background
Stachys lavandulifolia Vahl. is an herbaceous plant native to Iran, Turkey, Armenia, Azerbaijan, Iraq, and Turkmenistan [PMID:38189318, PMID:40899416]. In traditional Iranian medicine, it is considered equivalent to Marmazad [PMID:26734474].
Traditional uses
It is traditionally used as a mild sedative tea to reduce anxiety, for the treatment of gastrointestinal and respiratory disorders, and for painful conditions [PMID:29844776, PMID:23074920, PMID:29741912].
Active compounds
Chemical constituents include terpenoids, iridoids, flavonoids (such as apigenin, kumatakenin, and penduletin), and phenylethanoids [PMID:38189318, PMID:29844776]. Essential oil components include alpha-pinene, (E)-caryophyllene, germacrene D, delta-cadinene, alpha-thujone, and myrcene [PMID:40899416, PMID:23593591]. Other identified compounds include betulinic acid, oleanolic acid, rosmarinic acid, and ursolic acid [PMID:20738162].
Mechanism of action
The plant may act via the GABAergic and opioidergic systems to produce anticonvulsant and antispasmodic effects [PMID:36589024, PMID:24250359]. In the context of Polycystic Ovary Syndrome (PCOS), it is suggested to influence steroid hormone production, glucose homeostasis, and insulin resistance, targeting genes such as CYP19A1 and the human androgen receptor [PMID:40993927]. It may also decrease progesterone concentrations [PMID:27418911].
Clinical evidence
Evidence BOccupational Stress in EMTs
A clinical trial using 2g of tea daily for 2 months investigated its effect on occupational stress [PMID:37061348]
Evidence BPrimary Dysmenorrhea
A randomized, double-blind, crossover, placebo-controlled pilot study evaluated the efficacy of standardized capsules in reducing pain [PMID:29741912]
Evidence AVaginal Infections
A systematic review identified Stachys lavandulifolia as an Iranian medicinal plant with anti-vaginal infection properties [PMID:35490427]
Safety & adverse effects
Aqueous extract was found to have no significant hematological changes or mortality in sub-chronic toxicity studies in rats [PMID:25657785]. However, there are concerns regarding the potential pro-oxidant action of antioxidant supplementation [PMID:24027670].
Pregnancy & lactation
In pregnant mice, hydroalcoholic extracts caused a significant increase in absorbed fetuses and decreased fetus length and weight, suggesting potential abortifacient effects [PMID:27418911].
Evidence summary
Evidence consists of a mix of preclinical animal studies (mice/rats), in vitro cancer cell line research, and small-scale clinical trials. While traditional use is widespread, high-level clinical evidence (meta-analyses/large RCTs) is limited.
PubMed sources
1.PMID: 26734474 (2015) — Stachys lavandulifolia Vahl. and its Relation With Marmazad Activities in Traditional Manuscripts. · Iranian Red Crescent medical journal
2.PMID: 37061348 (2023) — Effect of stachys lavandulifolia on occupational stress in emergency medical technicians. · Explore (New York, N.Y.)
3.PMID: 38189318 (2024) — Botanical description, phytochemical constituents, ethnobotany, traditional medicinal use, and pharmacological activities of Stachys lavandulifolia Vahl. · Natural product research
4.PMID: 40899416 (2025) — Pharmacological and toxicological profile of the Stachys lavandulifolia Vahl: a comprehensive review. · Zeitschrift fur Naturforschung. C, Journal of biosciences
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Native Iranian Medicinal Plants with Anti-Vaginal Infection Properties: A Systematic Review.
· Infectious disorders drug targets
6.PMID: 41104247 (2025) — Anti-proliferative Activity and Apoptosis Induction of Extracts and Fractions of Stachys lavandulifolia on Lung (H1299), Ovarian (A2780) and Breast (MCF-7) Human Cancer Cell Lines. · Iranian journal of pharmaceutical research : IJPR
7.PMID: 36589024 (2022) — Effect of Hydroalcoholic Extract of Stachys lavandulifolia on Pentylenetetrazole-induced Seizures in Male Mice: The Role of GABAergic and Opioidergic Systems. · Basic and clinical neuroscience
8.PMID: 14611891 (2003) — Anxiolytic effects of Stachys lavandulifolia Vahl on the elevated plus-maze model of anxiety in mice. · Journal of ethnopharmacology
9.PMID: 40400719 (2025) — Investigating the effect aerials part of Stachys Lavandulifolia ointment on 2nd degree burns compared to silver sulfadiazine on male rat. · International journal of burns and trauma
10.PMID: 20738162 (2010) — Extended longevity of Drosophila melanogaster by water and ethanol extracts of Stachys lavandulifolia. · Pharmaceutical biology
11.PMID: 23593591 (2013) — Phytochemical composition of the essential oil of different populations of Stachys lavandulifolia Vahl. · Asian Pacific journal of tropical biomedicine
12.PMID: 34026076 (2021) — A comparative study: Influence of various drying methods on essential oil components and biological properties of Stachys lavandulifolia. · Food science & nutrition
13.PMID: 25657785 (2014) — Acute and subchronic toxicological evaluation of Stachys lavandulifolia aqueous extract in Wistar rats. · Research in pharmaceutical sciences
14.PMID: 29853127 (2018) — In situ green synthesis of Ag nanoparticles on herbal tea extract (Stachys lavandulifolia)-modified magnetic iron oxide nanoparticles as antibacterial agent and their 4-nitrophenol catalytic reduction activity. · Materials science & engineering. C, Materials for biological applications
15.PMID: 29741912 (2018) — Therapeutic Effects of Standardized Formulation of Stachys lavandulifolia Vahl on Primary Dysmenorrhea: A Randomized, Double-Blind, Crossover, Placebo-Controlled Pilot Study. · Journal of alternative and complementary medicine (New York, N.Y.)
16.PMID: 23074920 (2012) — Antimicrobial and antioxidant activities of Stachys lavandulifolia subsp. lavandulifolia essential oil and its infusion. · Natural product communications
17.PMID: 40993927 (2025) — Network Pharmacology Integrated Molecular Docking Analysis Identifies Potential Phytochemicals in Stachys lavandulifolia against Polycystic Ovary Syndrome. · Current pharmaceutical design
18.PMID: 27418911 (2012) — The effect of hydroalcoholic extract of Stachys lavandulifolia vahl on pregnant mice. · EXCLI journal
19.PMID: 29844776 (2017) — Isolation and Identification of Secondary Metabolites from the Aerial Parts of Stachys lavandulifolia Vahl. · Iranian journal of pharmaceutical research : IJPR
20.PMID: 37505651 (2023) — Potent In Vitro and In Vivo Effects of Stachys lavandulifolia Methanolic Extract against Toxoplasma gondii Infection. · Tropical medicine and infectious disease
21.PMID: 24027670 (2013) — Comment on: Anti-Oxidative Stress Activity of Stachys lavandulifolia Aqueous Extract in Humans. · Cell journal
22.PMID: 24250359 (2011) — Spasmolytic effect of stachys lavandulifolia vahl. Crude methanolic extract and fractions on rat ileum. · Iranian journal of pharmaceutical research : IJPR