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Tagetes minuta
Tagetes minuta
Digestive complaints in South American folk medicine
PubMed · Photodynamic activity of Tagetes minuta extracts against superficial fungal infections. (2020)
PubMed · Understanding the Effect of Different Abiotic Stresses on Wild Marigold (<i>Tagetes minuta</i> L.) and Role of Breeding Strategies for Developing Tolerant Lines. (2021)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tagetes minuta, also known as wild marigold or khaki weed, is a South American plant used in folk medicine and industry for its essential oils and bioactive compounds [PMID:30388858, 36501288].
Background
Tagetes minuta is a member of the Asteraceae (Compositae) family native to South America and has become established in other regions including China [PMID:36501288, 20309824]. It is utilized as an industrial crop for the fragrance and flavor industries due to its essential oil content [PMID:35185943, 37360726].
Traditional uses
It is used in folk medicine to treat dental, stomach, intestinal, emotional, and nervous disorders, as well as muscular pain [PMID:30388858]. In South America, it is used as a remedy for stomach and intestinal discomfort [PMID:33242619]. It has also been traditionally used as an antibacterial, insecticidal, biocide, disinfectant, anthelminthic, antifungal, antiseptic agent, and for urinary tract infections [PMID:28668646].
Active compounds
The plant contains essential oils, flavonoids (including quercetagetin derivatives), polyphenols, polysaccharides, thiophenes (such as thiotagetin A), terpenes, sterols, and phenolics [PMID:20309824, 27348403, 37373340, 24599122].
Mechanism of action
Hydroalcoholic extracts may inhibit inflammatory bowel disease by acting on the NF-κB signaling pathway [PMID:33242619]. Flower essential oils may attenuate depressive-like behavior by reversing oxidative stress in the hippocampus, decreasing plasma corticosterone levels, and restoring BDNF-Akt/ERK2 signaling [PMID:35219720]. Thiophenes in the plant can act as photosensitizers that produce reactive oxygen species (ROS) upon UVA irradiation to damage microorganisms [PMID:31724710].
Clinical evidence
Evidence DDepressive-like behavior (mouse model)
Administration of flower essential oil (10 and 50 mg/kg) reversed depressive-like behavior induced by stress or inflammatory challenge [PMID:35219720]
Evidence DSuperficial fungal infections (in vitro)
Root hexane and dichloromethane extracts demonstrated high photodynamic antifungal activity against Candida and dermatophytes when combined with UVA irradiation [PMID:31724710]
Evidence DInflammatory bowel disease (in vitro)
Hydroalcoholic extracts displayed anti-inflammatory activity in stomach, intestine, and monocyte cell lines [PMID:33242619]
Evidence DHyperglycemia (in vitro)
Isolated flavonoids from T. minuta can inhibit alpha-amylase, a carbohydrate-digesting enzyme [PMID:37373340]
Safety & adverse effects
T. minuta can cause allergic contact dermatitis [PMID:12793186]. The Scientific Committee on Consumer Safety (SCCS) considers a maximum level of 0.01% of extracts and essential oils in leave-on products safe, provided alpha terthienyl content does not exceed 0.35% [PMID:26721339].
Evidence summary
The majority of evidence is based on in vitro studies, animal models, or phytochemical reviews (Level C and D). There are no human clinical trials provided in the abstracts.
2.PMID: 35185943 (2021) — Understanding the Effect of Different Abiotic Stresses on Wild Marigold (Tagetes minuta L.) and Role of Breeding Strategies for Developing Tolerant Lines. · Frontiers in plant science
3.PMID: 30388858 (2018) — Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity. · Molecules (Basel, Switzerland)
4.PMID: 31724710 (2020) — Photodynamic activity of Tagetes minuta extracts against superficial fungal infections. · Medical mycology
5.PMID: 36501288 (2022) — Increased Invasion Risk of Tagetes minuta L. in China under Climate Change: A Study of the Potential Geographical Distributions.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 20309824 (2010) — Optimization of DNA extraction from seeds and fresh leaf tissues of wild marigold (Tagetes minuta) for polymerase chain reaction analysis. · Genetics and molecular research : GMR
7.PMID: 28668646 (2017) — Systematic review and technological overview of the antimicrobial activity of Tagetes minuta and future perspectives. · Journal of ethnopharmacology
8.PMID: 19290263 (1988) — Host Status of Five Weed Species and Their Effects on Pratylenchus zeae Infestation of Maize. · Journal of nematology
9.PMID: 26441652 (2015) — Acylated flavonol glycosides from Tagetes minuta with antibacterial activity. · Frontiers in pharmacology
10.PMID: 31317061 (2019) — Effects of Tagetes minuta essencial oil on Lucilia cuprina third instar larvae. · Data in brief
11.PMID: 34352469 (2021) — Foliar micromorphology, ultrastructure and histochemical analyses of Tagetes minuta L. leaves. · Micron (Oxford, England : 1993)
12.PMID: 34466524 (2019) — Plant-Derived Essential Oils; Their Larvicidal Properties and Potential Application for Control of Mosquito-Borne Diseases. · Galen medical journal
13.PMID: 37360726 (2023) — Achievement of higher biomass, yield and quality of essential oil of Tagetes minuta L. through optimizing the sowing method and seeding rate. · Frontiers in plant science
14.PMID: 35219720 (2022) — Flower essential oil of Tagetes minuta mitigates oxidative stress and restores BDNF-Akt/ERK2 signaling attenuating inflammation- and stress-induced depressive-like behavior in mice. · Brain research
15.PMID: 42262333 (2026) — Plant growth regulators and fertilizer increase phytoextraction efficiency of Tagetes minuta under lead-contaminated soil. · International journal of phytoremediation
16.PMID: 41527561 (2026) — Species diversity patterns in Tagetes minuta-invaded plant communities along an elevational gradient in Southeastern Xizang. · PeerJ
17.PMID: 39433300 (2024) — Peroxyl Radical Trapping Antioxidant Activity of Essential Oils and Their Phenolic Components. · Journal of agricultural and food chemistry
18.PMID: 33537054 (2020) — Nitrogen and Sulfur Fertilization Modulates the Yield, Essential Oil and Quality Traits of Wild Marigold (Tagetes minuta L.) in the Western Himalaya. · Frontiers in plant science
19.PMID: 32957146 (2021) — Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects. · Planta medica
20.PMID: 26721339 (2016) — Opinion of the Scientific Committee on Consumer Safety (SCCS) - Opinion on the fragrance ingredients Tagetes minuta and Tagetes patula extracts and essential oils (phototoxicity only) in cosmetic products. · Regulatory toxicology and pharmacology : RTP
21.PMID: 1895085 (1991) — Larvicidal activity of Tagetes minuta (marigold) toward Aedes aegypti. · Journal of the American Mosquito Control Association
22.PMID: 34082957 (2021) — A Tagetes minuta based eco-benign synthesis of multifunctional Au/MgO nanocomposite with enhanced photocatalytic, antibacterial and DPPH scavenging activities. · Materials science & engineering. C, Materials for biological applications
23.PMID: 33742040 (2021) — Antimicrobial and physical properties of experimental endodontic sealers containing vegetable extracts. · Scientific reports
24.PMID: 36903846 (2023) — The Dual Benefit of Plant Essential Oils against Tuta absoluta. · Plants (Basel, Switzerland)
25.PMID: 27348403 (2017) — Thiotagetin A, a new cytotoxic thiophene from Tagetes minuta. · Natural product research
26.PMID: 35056883 (2022) — Chemical Composition and Insecticidal Activities of Essential Oils against the Pulse Beetle. · Molecules (Basel, Switzerland)
27.PMID: 24599122 (2014) — New thiophene and flavonoid from Tagetes minuta leaves growing in Saudi Arabia. · Molecules (Basel, Switzerland)
28.PMID: 37373340 (2023) — Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies. · International journal of molecular sciences
29.PMID: 33242619 (2021) — Hydroalcoholic extract of Tagetes minuta L. inhibits inflammatory bowel disease through the activity of pheophytins on the NF-κB signalling pathway. · Journal of ethnopharmacology
30.PMID: 28202077 (2017) — Repellent effects of the essential oils of Cymbopogon citratus and Tagetes minuta on the sandfly, Phlebotomus duboscqi. · BMC research notes