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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Artemisia dracunculus (tarragon) is a perennial Asteraceae species used globally as a spice and traditional remedy [PMID:33927629, PMID:21942448, PMID:30731940].
Background
Tarragon is a species of the Asteraceae family used as a spice in Asia, Europe, and the Americas [PMID:33927629]. Two widely used cultivars, Russian and French, differ in morphology, ploidy level, and chemical composition [PMID:21942448].
Traditional uses
In traditional Asian medicine (specifically Iran, Pakistan, Azerbaijan, and India), it is used for digestive system diseases, as an analgesic, hypnotic, antiepileptic, anti-inflammatory, antipyretic agent, and for treating helminthiasis [PMID:33927629].
Active compounds
Key bioactive metabolites include essential oils (0.15-3.1%), coumarins (such as herniarine and 5,7-Dihydroxy-4-methylcoumarin), flavonoids (including kaempferol), phenolic acids, and alkamides (such as pellitorine, neopellitorine A, and neopellitorine B) [PMID:21942448, PMID:11730872, PMID:39800268, PMID:36082856]. Major essential oil constituents include eugenol, estragole (up to 82%), and methyleugenol (up to 39%) [PMID:21942448, PMID:38068651].
Mechanism of action
Tarragon extracts can inhibit reactive oxygen species (ROS), interleukin 8 (IL-8), and tumour necrosis factor α (TNF-α) production in human neutrophils [PMID:32903580]. Specific compounds like 5,7-Dihydroxy-4-methylcoumarin may enhance osteogenesis via the AKT1 pathway [PMID:39800268]. Certain alkamides act as dose-dependent inhibitors of cytochrome P450 3A4 (CYP3A4) activity [PMID:22738981].
Clinical evidence
Evidence CInflammation and Pain
Pharmacological studies have confirmed anti-inflammatory and analgesic effects [PMID:33927629].
Evidence CNeuropathic Pain
Identified as a plant exhibiting protective effects in neuropathic pain models [PMID:29796216].
Evidence DHyperglycemia
In vivo rodent studies suggest potential antihyperglycemic effects [PMID:21942448]; extract PMI5011 improves blood glucose and insulin sensitivity via skeletal muscle [PMID:37686232].
Evidence DAutoimmune Encephalomyelitis (EAE)
Aqueous extract (500 mg/kg) significantly ameliorated clinical scores of EAE in mice [PMID:32245296].
Evidence DOsteoporosis
The compound 5,7-Dihydroxy-4-methylcoumarin (D4M) enhances osteoblastogenesis and ameliorates osteoporosis in a zebrafish model [PMID:39800268].
Safety & adverse effects
Concerns exist regarding the hepatocarcinogenicity of estragole and methyleugenol [PMID:21942448, PMID:11077188, PMID:27761422]. However, no acute toxicity or mutagenic activity has been reported at doses relevant for human consumption [PMID:21942448]. Desiccated tarragon powder was not genotoxic in vivo at doses up to 6.25 g/kg bw [PMID:19913108]. A case of life-threatening glottal edema occurred in a florist with pre-existing sunflower allergy who showed strong sensitization against mugwort and tarragon [PMID:16285482].
Drug interactions
Tarragon contains compounds that act as effective inhibitors of cytochrome P450 3A4 (CYP3A4) [PMID:22738981].
Evidence summary
The evidence is primarily based on in vitro studies, animal models (rodents and zebrafish), and review articles. There is a lack of human clinical trials.
PubMed sources
1.PMID: 33927629 (2021) — Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. · Frontiers in pharmacology
2.PMID: 21942448 (2011) — Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. · Journal of agricultural and food chemistry
3.PMID: 23010670 (2013) — Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
4.PMID: 11730872 (2001) — Alkamides from Artemisia dracunculus. · Phytochemistry
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
· Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
6.PMID: 40863944 (2025) — Effects of Tarragon Hydrodistillate and Essential Oil on Aquatic Ecosystems. · Toxics
7.PMID: 37112055 (2023) — Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites. · Polymers
8.PMID: 38247749 (2023) — Antimicrobial Activity of Artemisia dracunculus Oil-Loaded Agarose/Poly(Vinyl Alcohol) Hydrogel for Bio-Applications. · Gels (Basel, Switzerland)
9.PMID: 37686232 (2023) — Extract of Artemisia dracunculus L. Modulates Osteoblast Proliferation and Mineralization. · International journal of molecular sciences
10.PMID: 36234965 (2022) — Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. · Molecules (Basel, Switzerland)
11.PMID: 32234442 (2020) — Effect of chitosan-whey protein isolated coatings incorporated with tarragon Artemisia dracunculus essential oil on the quality of Scomberoides commersonnianus fillets at refrigerated condition. · International journal of biological macromolecules
12.PMID: 39199260 (2024) — Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum. · Antioxidants (Basel, Switzerland)
13.PMID: 22738981 (2012) — Effective cytochrome P450 (CYP) inhibitors isolated from tarragon (Artemisia dracunculus). · Bioscience, biotechnology, and biochemistry
14.PMID: 21821921 (2011) — Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus. · Bioscience, biotechnology, and biochemistry
15.PMID: 19913108 (2010) — Risk assessment of consumption of methylchavicol and tarragon: the genotoxic potential in vivo and in vitro. · Mutation research
16.PMID: 28729836 (2017) — An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes. · Frontiers in pharmacology
17.PMID: 32903580 (2020) — Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion-Phytochemical Characterization. · Frontiers in pharmacology
18.PMID: 29796216 (2018) — Medicinal herbs in the treatment of neuropathic pain: a review. · Iranian journal of basic medical sciences
19.PMID: 39800268 (2025) — 5,7-Dihydroxy-4-Methylcoumarin enhances osteogenesis and ameliorates osteoporosis via the AKT1 pathway. · Biochemical pharmacology
20.PMID: 18555848 (2008) — Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity. · Metabolism: clinical and experimental
21.PMID: 11077188 (2000) — Constituents of aromatic plants: II. Estragole. · Fitoterapia
22.PMID: 36082856 (2022) — Anticancer Properties of Kaempferol on Cellular Signaling Pathways. · Current topics in medicinal chemistry
23.PMID: 27761422 (2016) — Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects. · Avicenna journal of phytomedicine
24.PMID: 32245296 (2019) — The Effect of Aqueous Extract of Tarragon on Clinical Symptoms and T Cell Differentiation in Experimental Autoimmune Encephalomyelitis. · Iranian journal of allergy, asthma, and immunology
25.PMID: 35161282 (2022) — Characterization of Ingredients Incorporated in the Traditional Mixed-Salad of the Capuchin Monks. · Plants (Basel, Switzerland)
26.PMID: 30731940 (2011) — Fusarium Crown and Root Rot of Tarragon in California Caused by Fusarium solani. · Plant disease
27.PMID: 38068651 (2023) — Unraveling the Potential of Organic Oregano and Tarragon Essential Oils: Profiling Composition, FT-IR and Bioactivities. · Plants (Basel, Switzerland)