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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tectona grandis, commonly known as teak, is a biologically valuable member of the Lamiaceae (mint) family used both as a high-value timber and in traditional medicine [PMID:29506390, PMID:40783105].
Background
Tectona grandis is a tropical timber tree renowned for its durability, strength, and resistance to termite and fungal damage [PMID:29506390, PMID:29800113].
Traditional uses
In traditional Dai medicine and other indigenous systems, it is used to treat malaria, inflammation, diabetes, liver disease, bronchitis, tumors, cholelithiasis, jaundice, skin disease, the common cold, headaches, scabies, and as an anti-helminthic [PMID:36978912, PMID:38151632, PMID:35280534].
Active compounds
Active constituents include naphthoquinones (such as lapachol and deoxylapachol), anthraquinones (such as 1-hydroxy-2,6,8-trimethoxy-9,10-anthraquinone and 2-methylanthraquinone), isoprenoid quinones, tectoquinone, triterpenoids, steroids, lignans, fatty esters, phenolic compounds, and diterpenoids [PMID:29506390, PMID:38151632, PMID:36323840, PMID:40733162]. Specific 5-alpha reductase inhibitors identified include (+)-eperua-8,13-dien-15-oic acid and (+)-eperua-7,13-dien-15-oic acid [PMID:35566245].
Mechanism of action
Tectona grandis leaf extracts exhibit inhibitory activity against steroid 5-alpha reductase (S5AR), which prevents the conversion of testosterone to dihydrotestosterone (DHT) [PMID:39474646, PMID:40733162]. Additionally, metabolites have been shown to modulate the NLRP3 inflammasome axis to alleviate neurological dysfunction [PMID:40783105].
Clinical evidence
Evidence BAndrogenic Alopecia
A hair tonic containing 1% teak leaf extract was evaluated for effectiveness and safety as a hair growth promoter in males [PMID:39474646]
Evidence DOxaliplatin-induced chemofog
Ethanol extract of T. grandis leaves and its nanoformulation alleviated neurological dysfunction in rats via modulation of the NLRP3 inflammasome axis [PMID:40783105]
Evidence DDiabetes Mellitus
Teak leaf ethanol extract was studied in diabetic rats for its effects on nitric oxide and malondialdehyde levels [PMID:37779332]
Safety & adverse effects
Tectona grandis is a potent sensitizer; exposure to teak dust can cause allergic contact eczema and severe itching [PMID:14459786]. Lapachol has been identified as one of the sensitizing agents in teak wood [PMID:14106137].
Evidence summary
The evidence consists primarily of review articles and preclinical animal or in vitro studies (Level C and D), with one randomized controlled trial (Level B) regarding hair growth.
PubMed sources
1.PMID: 29506390 (2019) — Tectona grandis (teak) - A review on its phytochemical and therapeutic potential. · Natural product research
2.PMID: 35280534 (2022) — Tectona grandis L.f: A comprehensive review on its patents, chemical constituents, and biological activities. · Saudi journal of biological sciences
3.PMID: 40783105 (2025) — Tectona grandis metabolites alleviate oxaliplatin-induced chemofog in rats: Modulation of the NLRP3 inflammasome axis. · Journal of ethnopharmacology
4.PMID: 14106137 (1964) — CONTACT ECZEMA CAUSED BY TRUE TEAK (TECTONA GRANDIS). A FOLLOW-UP STUDY OF A PREVIOUS EPIDEMIOLOGICAL INVESTIGATION, AND A STUDY INTO THE SENSITIZING EFFECT OF VARIOUS TEAK EXTRACTS. · British journal of industrial medicine
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Effects of Tectona grandis L. Extract in Diabetic Rats on Nitric Oxide and Malondialdehyde Levels.
· Pakistan journal of biological sciences : PJBS
6.PMID: 39474646 (2024) — Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandis L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia. · Journal of evidence-based integrative medicine
7.PMID: 14459786 (1962) — Contact eczema caused by true teak (Tectona grandis). An epidemiological investigation in a furniture factory. · British journal of industrial medicine
8.PMID: 40733162 (2025) — Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves. · Molecules (Basel, Switzerland)
9.PMID: 36978912 (2023) — Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Tectona grandis Methanolic Extracts, Fractions, and Isolated Compounds. · Antioxidants (Basel, Switzerland)
10.PMID: 35566245 (2022) — Isolation and HPLC Quantitative Determination of 5α-Reductase Inhibitors from Tectona grandis L.f. Leaf Extract. · Molecules (Basel, Switzerland)
11.PMID: 38151632 (2024) — Compound isolation through bioassay-guided fractionation of Tectona grandis leaf extract against Vibrio pathogens in shrimp. · International microbiology : the official journal of the Spanish Society for Microbiology
12.PMID: 36323840 (2022) — Chemical composition of heartwood and sapwood of Tectona grandis characterized by CG/MS-PY. · Scientific reports
13.PMID: 29800113 (2018) — Draft genome of a high value tropical timber tree, Teak (Tectona grandis L. f): insights into SSR diversity, phylogeny and conservation. · DNA research : an international journal for rapid publication of reports on genes and genomes