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PubMed · [Aerobiological study in Lima, Perú. ¿Tipuana-Tipu, perhaps a new allergen?]. (2024)
PubMed · LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches. (2024)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tipuana tipu is a leguminous tree indigenous to Argentina and used extensively in urban landscaping [PMID:12710729]. It is studied for its potential antioxidant, anti-inflammatory, and antidiabetic properties [PMID:38671392, PMID:42245235].
Background
Tipuana tipu (Benth.) Kuntze is a tree of the Fabaceae family (Papilionoideae) indigenous to Argentina and widely used in urbanism, particularly in Southern Brazil [PMID:12710729, PMID:37312011].
Traditional uses
Tipuana tipu is described as a leguminous plant traditionally valued for various medicinal properties [PMID:42245235].
Active compounds
The flowers contain bioactive components analyzed via LC-MS/MS [PMID:38671392]. Leaf extracts contain flavonoids including kaempferol, quercetin, rutin, and chlorogenic acid [PMID:24144158, PMID:25169776]. Epicuticular waxes of leaves, branches, and flowers contain aliphatic alcohols, alkanes, aliphatic acids, and lupeol and b-amyrin hexadecanoates [PMID:12710729]. Essential oils from different parts of the tree contain sesquiterpene hydrocarbons (e.g., β-caryophyllene, germacrene D) in roots, and non-terpene hydrocarbons (e.g., n-tetradecane, 1,7-dimethylnaphthalene, n-octadecane) in pods, leaves, stems, and flowers [PMID:26916976]. Leaf leachates are characterized by condensed tannins and oxalic acid (cyclohexyl hexyl ester) [PMID:41480725].
Mechanism of action
In silico docking suggests that phytocompounds from T. tipu leaves (nonadecanol, alpinumisoflavone, β-sitosterol glucoside, protocatechualdehyde, and protocatechuic acid) may bind with carbohydrate-digesting enzymes α-amylase and α-glucosidase [PMID:42245235]. Methanol extracts of flowers have shown inhibitory activity against iNOS, NO production, and pro-inflammatory cytokines including NF-KB, TNF-R2, TNF-α, IL-1β, and IL-6 in LPS-activated RAW 264.7 macrophages [PMID:38671392].
Clinical evidence
Evidence DHyperglycemia
Methanolic extract of T. tipu (METT) demonstrated glucose-lowering activity in streptozotocin-induced diabetic rats [PMID:42245235]
Evidence DInflammation
Leaf extracts containing acylated kaempferol glycosides showed anti-inflammatory activity in a carrageenin-induced rat paw oedema model [PMID:25169776]
Evidence DOxidative Stress
Methanol extracts of flowers exhibited antioxidant activity in DPPH, ABTS, and FRAP assays [PMID:38671392]
Safety & adverse effects
Tipuana tipu pollen has been reported as a potential new allergen capable of triggering allergic symptoms [PMID:38683076].
Evidence summary
The current evidence for Tipuana tipu is primarily based on in vitro assays and animal models (Level D), focusing on phytochemical profiling and preliminary pharmacological activities such as antioxidant, anti-inflammatory, and antihyperglycemic effects.
PubMed sources
1.PMID: 37312011 (2023) — Predatory Arthropods Associated with the Invasive Tipu Psyllid, Platycorypha nigrivirga, in Southern Spain. · Neotropical entomology
2.PMID: 38671392 (2024) — LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches. · BMC complementary medicine and therapies
3.PMID: 38683076 (2024) — [Aerobiological study in Lima, Perú. ¿Tipuana-Tipu, perhaps a new allergen?]. · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
4.PMID: 42245235 (2026) — Antidiabetic effects of Tipuana tipu leaves: in silico docking and experimental study in streptozotocin-induced diabetic rats. · In silico pharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Chemical composition of Tipuana tipu, a source for tropical honey bee products.
· Zeitschrift fur Naturforschung. C, Journal of biosciences
6.PMID: 26916976 (2016) — Chemical Composition and Allelopathic Potential of Essential Oils from Tipuana tipu (Benth.) Kuntze Cultivated in Tunisia. · Chemistry & biodiversity
7.PMID: 24144158 (2014) — Flavonoids with acetylated branched glycans and bioactivity of Tipuana tipu (Benth.) Kuntze leaf extract. · Natural product research
8.PMID: 25169776 (2015) — A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves. · Natural product research
9.PMID: 41480725 (2026) — From fertilizer to insecticide: urban leaf litter chemistry alters the survival landscape of Aedes aegypti. · Pest management science