PubMed-compiled information sheet
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Compiled from 5 PubMed articles · model: gemma4:31b
Summary
Tordylium apulum is a Mediterranean plant used in ethnomedicine and as a traditional food source, demonstrating antioxidant and cytotoxic properties in vitro [PMID:37486088, PMID:30949221, PMID:9525110].
Background
Tordylium apulum L. is a member of the Apiaceae family distributed across countries bordering the Mediterranean [PMID:37486088]. It is utilized as a traditional food and in ethnomedicine, particularly in the Eastern Mediterranean [PMID:37486088].
Traditional uses
The plant is widely used in ethnomedicine in various Mediterranean countries and is consumed as a traditional food, including in salads and soups in Central Italy [PMID:37486088, PMID:30949221].
Active compounds
The essential oil contains monoterpene hydrocarbons (68.8%), specifically β-cis-ocimene (65.0%) and octyl hexanoate (14.4%) [PMID:37486088]. Additionally, seven coumarins have been isolated from the aerial parts of the plant [PMID:9525110, PMID:17253232].
Mechanism of action
Extracts from the leaves show inhibitory activity against bovine brain lipid peroxidation [PMID:12203269]. Certain isolated coumarins exhibit antiproliferative effects on the cell cycle of the NSCLC-N6 non-small-cell bronchial carcinoma line [PMID:9525110, PMID:17253232].
Clinical evidence
Evidence DOxidative Stress
Leaf extracts demonstrated remarkable inhibitory activity (> 50%) in a lipid peroxidation assay [PMID:12203269].
Evidence DNon-small-cell bronchial carcinoma (in vitro)
Isolated coumarins showed cytotoxicity and antiproliferative effects against the NSCLC-N6 cell line [PMID:9525110, PMID:17253232].
Evidence summary
The current evidence is limited to in vitro studies and chemical analyses (Level D), focusing on antioxidant capacity and cytotoxic potential against cancer cell lines.
PubMed sources
- 1.PMID: 37486088 (2024) — Chemical composition and antioxidant activities of the essential oil of Tordylium apulum L. collected in Sicily. · Natural product research
- 2.PMID: 30949221 (2019) — Traditional Salads and Soups with Wild Plants as a Source of Antioxidants: A Comparative Chemical Analysis of Five Species Growing in Central Italy. · Evidence-based complementary and alternative medicine : eCAM
- 3.PMID: 9525110 (1998) — Cytotoxic coumarins from the aerial parts of Tordylium apulum and their effects on a non-small-cell bronchial carcinoma line. · Planta medica
- 4.PMID: 12203269 (2002) — In vitro antioxidant activity of non-cultivated vegetables of ethnic Albanians in southern Italy. · Phytotherapy research : PTR
- 5.PMID: 17253232