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Tulbaghia violacea
Tulbaghia violacea
Traditional Zulu and Sotho medicine for fever infections and hypertension
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tulbaghia violacea is a medicinal bulbous herb indigenous to southern Africa, recognized for its antimicrobial, antioxidant, and antihypertensive properties [PMID:23838476, 27008423].
Background
Tulbaghia violacea, also known as wild garlic, society garlic, or sweet garlic, is a monocotyledonous herbaceous perennial bulb endemic to Southern Africa [PMID:23838476, 23291533]. It belongs to the Alliaceae family [PMID:27008423, 22222281].
Traditional uses
Traditionally, it is used as an infusion or boiled in water to treat fever, colds, influenza, asthma, tuberculosis, and stomach problems [PMID:27008423]. It is used as an antihypertensive, to expel intestinal worms, and externally in medicated baths for paralysis, rheumatism, and fever reduction [PMID:27008423, 22222281].
Active compounds
The plant contains marasmin [S-(methylthiomethyl)-L-cysteine-4-oxide] [PMID:36349240, 11985847], as well as flavonols, anthocyanins, and other phenolic compounds [PMID:35094882]. Phytochemical screening has identified flavonoids, glycosides, tannins, terpenoids, saponins, and steroids [PMID:32186066, 28132403]. Volatile compounds include (Z)-3-Hexenyl acetate, benzyl alcohol, nonanal, and decanal [PMID:36501344].
Mechanism of action
Anti-parasitic activity against Trypanosoma brucei is linked to the irreversible inhibition of the trypanothione reductase enzyme [PMID:29393867]. Antifungal activity against Aspergillus flavus is mediated by the reduction of ergosterol production and the decline of beta-glucan and chitin synthesis [PMID:34100987, 28132403]. Antihypertensive effects are attributed to angiotensin-converting enzyme-inhibitory (ACEI) activity [PMID:25017374].
Clinical evidence
Evidence DHypertension
Methanolic extracts reduced systolic blood pressure in Dahl salt-sensitive rats [PMID:23291533, 25017374] and spontaneously hypertensive Wistar rats [PMID:22222281].
Evidence DDiabetes Mellitus
Rhizome methanolic extract showed antioxidant, antidiabetic, and hypolipidemic effects in streptozotocin-induced diabetic rat models [PMID:26577219, 28852727].
Evidence DCancer
Water-soluble extracts exhibited anti-cancer activity against ovarian tumoral cells and triple-negative breast cancer (TNBC) metastasis in vitro [PMID:35094882, 39451522, 25683299].
Evidence DParasitic Infections
Dichloromethane extracts showed trypanocidal and leishmanicidal activity against Trypanosoma brucei brucei and Leishmania tarentolae [PMID:29393867].
Evidence DFungal Infections
Extracts showed antifungal activity against Candida, Aspergillus flavus, and Aspergillus parasiticus [PMID:34100987, 16835880].
Evidence D
Safety & adverse effects
Dichloromethane extracts showed mild cytotoxic activity against human keratinocytes [PMID:29393867].
Evidence summary
The current evidence consists primarily of in vitro studies and animal models (Level D), demonstrating significant pharmacological potential in antihypertensive, antidiabetic, and antimicrobial activities, but lacks human clinical trials.
PubMed sources
1.PMID: 27008423 (2016) — Tulbaghia--A Southern African Phytomedicine. · Journal of alternative and complementary medicine (New York, N.Y.)
2.PMID: 23838476 (2013) — The genus Tulbaghia (Alliaceae)--a review of its ethnobotany, pharmacology, phytochemistry and conservation needs. · Journal of ethnopharmacology
3.PMID: 29393867 (2018) — Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities. · Molecules (Basel, Switzerland)
4.PMID: 35094882 (2022) — Unravelling potential biomedical applications of the edible flower Tulbaghia violacea. · Food chemistry
5.PMID: 36349240 (2022) — Identification of a regiospecific S-oxygenase for the production of marasmin in traditional medicinal plant Tulbaghia violacea.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Extracts reduced 1-42 beta amyloid peptide formation and prevented oxidative stress in Caenorhabditis elegans [PMID:35094882].
· Plant biotechnology (Tokyo, Japan)
6.PMID: 25017374 (2014) — Effects of Tulbaghia violacea Harv. (Alliaceae) rhizome methanolic extract on kidney function and morphology in Dahl salt-sensitive rats. · Journal of ethnopharmacology
7.PMID: 28852727 (2016) — METABOLIC EFFECTS OF TULBAGHIA VIOLACEA HARV. IN A DIABETIC MODEL. · African journal of traditional, complementary, and alternative medicines : AJTCAM
8.PMID: 36501344 (2022) — The Green Leaf Volatile (Z)-3-Hexenyl Acetate Is Differently Emitted by Two Varieties of Tulbaghia violacea Plants Routinely and after Wounding. · Plants (Basel, Switzerland)
9.PMID: 22222281 (2012) — Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. · Journal of ethnopharmacology
10.PMID: 23291533 (2013) — Cardiovascular effects of Tulbaghia violacea Harv. (Alliaceae) root methanolic extract in Dahl salt-sensitive (DSS) rats. · Journal of ethnopharmacology
12.PMID: 32186066 (2018) — Analysis of the phytochemical contents and antioxidant activities of crude extracts from Tulbaghia species. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
13.PMID: 34100987 (2021) — Tulbaghia violacea (Harv) Exerts its Antifungal Activity by Reducing Ergosterol Production in Aspergillus flavus. · Current microbiology
14.PMID: 25683299 (2015) — In vitro cytotoxic and pro-apoptotic effects of water extracts of Tulbaghia violacea leaves and bulbs. · Journal of ethnopharmacology
15.PMID: 16835880 (2006) — Tulbaghia alliacea phytotherapy: a potential anti-infective remedy for candidiasis. · Phytotherapy research : PTR
16.PMID: 39451522 (2024) — Exploring Water-Soluble South African Tulbaghia violacea Harv Extract as a Therapeutic Approach for Triple-Negative Breast Cancer Metastasis. · Current issues in molecular biology
17.PMID: 11985847 (2002) — The amino acid precursors and odor formation in society garlic (Tulbaghia violacea Harv.). · Phytochemistry
18.PMID: 26577219 (2015) — Antioxidant, antidiabetic and hypolipidemic effects of Tulbaghia violacea Harv. (wild garlic) rhizome methanolic extract in a diabetic rat model. · BMC complementary and alternative medicine