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Viburnum Opulus Herb
Viburnum opulus
menstrual cramp treatment in European and Native American folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Viburnum opulus, also known as Guelder rose or Gilaburu, is a deciduous shrub with antioxidant and medicinal properties used in traditional medicine [PMID:33167421, PMID:38280176].
Background
Viburnum opulus is a deciduous shrub found in Europe, Russia, North Africa, and North Asia [PMID:33167421]. It is utilized as a decorative, food, and medicinal plant [PMID:33167421].
Traditional uses
Traditionally used to treat cough, colds, tuberculosis, rheumatic aches, ulcers, stomach and kidney problems [PMID:33167421]. In Türkiye, it is used ethnobotanically for kidney stones, stomach, heart, liver diseases, hemorrhages, hypertension, ulcers, common cold, tuberculosis, rheumatic and menstrual pain, and diabetes [PMID:38128893].
Active compounds
The plant contains phenolic compounds, including flavonoids and phenolic acids (notably chlorogenic acid, gallic acid, vanillic acid, protocatechuic acid, and ferulic acid) [PMID:33167421, PMID:36903530, PMID:37893661, PMID:35630596]. Other components include carotenoids, organic acids (acetic, citric, succinic, and malic), iridoids, quercetin and (epi)catechin derivatives, flavalignans, procyanidins, and anthocyanins [PMID:31321622, PMID:37893661, PMID:33036189].
Mechanism of action
V. opulus exhibits antioxidant activity and inhibits $\alpha$-amylase and $\alpha$-glucosidase enzymes [PMID:33167421, PMID:35630596]. It has demonstrated the ability to inhibit arginase activity and induce endothelium-dependent vasorelaxation in rat aortic rings [PMID:31437471]. In cell studies, it downregulates PPAR$\gamma$, C/EBP$\alpha$, and SREBP-1c to inhibit adipogenesis [PMID:32640537].
Clinical evidence
Evidence BDistal ureteral calculi ($\le$10 mm)
Viburnum opulus extract (1000 mg peroral 3 $\times$ 2) was found to be as effective as Tamsulosin (0.4 mg peroral 1 $\times$ 1) in terms of stone expulsion rates and time until expulsion [PMID:34610178].
Evidence CPremenstrual Syndrome (PMS)
Used as a botanical supplement, though rigorous clinical trials have not been performed [PMID:27677719].
Safety & adverse effects
In subacute oral toxicity tests in mice, doses of 2000 mg/kg for 28 days resulted in significantly high platelet counts and toxicity to the kidney, liver, and adipose tissue [PMID:37783419]. Acute tests in rats showed no clinical signs of toxicity or mortality at a single dose of 2000 mg/kg [PMID:37783419].
Evidence summary
Evidence is primarily based on in vitro and in vivo animal studies (Level D) and reviews (Level C), with one randomized controlled trial (Level B) supporting its use in medical expulsive therapy for ureteral stones.
PubMed sources
1.PMID: 27677719 (2016) — Botanicals and Their Bioactive Phytochemicals for Women's Health. · Pharmacological reviews
2.PMID: 33167421 (2020) — Viburnum opulus L.-A Review of Phytochemistry and Biological Effects. · Nutrients
3.PMID: 38280176 (2024) — Fruits of Wild-Grown Shrubs for Health Nutrition. · Plant foods for human nutrition (Dordrecht, Netherlands)
4.PMID: 36903530 (2023) — Flavonoids and Phenolic Acids Content in Cultivation and Wild Collection of European Cranberry Bush Viburnum opulus L. · Molecules (Basel, Switzerland)
5.PMID: 32640537 (2020) — Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 37893661 (2023) — Characterization of Fruit Vinegars via Bioactive and Organic Acid Profile Using Chemometrics. · Foods (Basel, Switzerland)
7.PMID: 36615436 (2022) — Antimicrobial Activities Evaluation and Phytochemical Screening of Some Selected Plant Materials Used in Traditional Medicine. · Molecules (Basel, Switzerland)
8.PMID: 28602011 (2018) — Differences in the fruit structure and the location and content of bioactive substances in Viburnum opulus and Viburnum lantana fruits. · Protoplasma
9.PMID: 17852468 (2008) — Antioxidant properties of Viburnum opulus and Viburnum lantana growing in Turkey. · International journal of food sciences and nutrition
10.PMID: 32664580 (2020) — Viburnum opulus L. Juice Phenolic Compounds Influence Osteogenic Differentiation in Human Osteosarcoma Saos-2 Cells. · International journal of molecular sciences
11.PMID: 31321622 (2019) — Comparison of Chemical Composition and Antioxidant Capacity of Fruit, Flower and Bark of Viburnum opulus. · Plant foods for human nutrition (Dordrecht, Netherlands)
12.PMID: 25641457 (2014) — Viburnum opulus: could it be a new alternative, such as lemon juice, to pharmacological therapy in hypocitraturic stone patients? · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
13.PMID: 37783419 (2023) — Safety assessment of European cranberrybush (Viburnum opulus L.) fruit juice: Acute and subacute oral toxicity. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
14.PMID: 35630596 (2022) — In Vitro Inhibitory Effects of Viburnum opulus Bark and Flower Extracts on Digestion of Potato Starch and Carbohydrate Hydrolases Activity. · Molecules (Basel, Switzerland)
15.PMID: 32429334 (2020) — Evaluation of Viburnum opulus L. Fruit Phenolics Cytoprotective Potential on Insulinoma MIN6 Cells Relevant for Diabetes Mellitus and Obesity. · Antioxidants (Basel, Switzerland)
16.PMID: 33801012 (2021) — An In Vitro Study of the Effect of Viburnum opulus Extracts on Key Processes in the Development of Staphylococcal Infections. · Molecules (Basel, Switzerland)
17.PMID: 31374918 (2019) — Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells. · Antioxidants (Basel, Switzerland)
18.PMID: 34610178 (2021) — Gilaburu extract (Viburnum opulus Linnaeus) is as effective as Tamsulosin in medical expulsive therapy of distal ureteral calculi. · International journal of clinical practice
19.PMID: 39363007 (2024) — Change of bioactive properties, spectral reflectance, and color characteristics of European cranberry (Viburnum opulus L.) juice as affected by foam mat drying technique. · Scientific reports
20.PMID: 42240091 (2026) — Ultrasound- and Enzyme-Assisted Valorization of Defatted Viburnum opulus L. Berry Pomace for the Development of Advanced Ingredients and Bread Fortification. · Journal of food science
21.PMID: 34205673 (2021) — Glycoside Hydrolases and Non-Enzymatic Glycation Inhibitory Potential of Viburnum opulus L. Fruit-In Vitro Studies. · Antioxidants (Basel, Switzerland)
22.PMID: 38128893 (2024) — Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage. · Journal of ethnopharmacology
23.PMID: 33036189 (2020) — Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities. · Foods (Basel, Switzerland)
24.PMID: 41026623 (2025) — Comparative Study of Antidiabetic and Antioxidant Properties of Viburnum opulus L. and Viburnum lantana L. (Viburnaceae): LC-MS/MS Profiling of Phenolic Compounds. · Chemistry & biodiversity
25.PMID: 31437471 (2019) — Metabolite profiling, arginase inhibition and vasorelaxant activity of Cornus mas, Sorbus aucuparia and Viburnum opulus fruit extracts. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
26.PMID: 30978165 (2019) — The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones. · Turkish journal of urology