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Not CommonAI-summarized
Viola Odorata Herb
Viola odorata
respiratory mucus remedy in European folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Viola odorata, also known as sweet violet or English violet, is a perennially herbaceous plant found in Europe and Asia with various medicinal applications [PMID:37694059].
Background
Viola odorata is a tough, perennially herbaceous flowering plant native to Europe and Asia [PMID:37694059].
Traditional uses
In traditional Persian medicine, it is used to manage cough, fever, common cold, headache, insomnia, epilepsy, constipation, palpitation, dyspnea, dysuria, and skin diseases [PMID:28948657]. It is also traditionally used for the treatment of diabetes [PMID:33490239] and neuropsychiatric disorders [PMID:29775777].
Active compounds
Phytochemical constituents include coumarins (such as umbelliferone and esculetin), caffeic acid, methyl salicylate, flavonoids (quercetin, kaempferol), glycosides (rutin), and terpenoids (stigma sterol) [PMID:37694059]. It also contains procyanidins (specifically procyanidin C1) [PMID:35487935], anthocyanins [PMID:35591648], and cyclic peptides known as cyclotides (e.g., cycloviolacin O1, cycloviolacin O2, and vodo-C1) as well as acyclotides (e.g., violacin A) [PMID:31812106, PMID:37099442, PMID:36107799, PMID:38679329].
Mechanism of action
Procyanidin C1 from V. odorata inhibits Na+,K+-ATPase [PMID:35487935]. Certain flavonoid derivatives may involve a serotonergic mechanism for antidepressant-like effects [PMID:29775777]. The plant's extracts have demonstrated the ability to reduce intracellular reactive oxygen species (ROS) and inhibit cellular tyrosinase [PMID:27516984, PMID:28392894]. Additionally, the cyclotide vodo-C1 has been identified as a ligand for the cannabinoid type 2 receptor (CB2R) [PMID:38679329].
Clinical evidence
Evidence AInsomnia
A systematic review and meta-analysis of five clinical trials (224 patients) showed significant improvement in total PSQI scores, subjective sleep quality, and sleep duration compared to placebo [PMID:35734476].
Evidence BChronic Insomnia
Intranasal drops of violet oil significantly improved sleep and Insomnia Severity Index (ISI) scores over one month [PMID:25763239].
Evidence BFever in children
Topical application of viola oil (20 drops) to the umbilicus significantly reduced mean axillary temperature after 30 minutes compared to placebo [PMID:31250761].
Evidence BCOVID-19
A randomized double-blind controlled trial evaluated the efficacy of sweet violet syrup in alleviating manifestations of COVID-19 infection [PMID:36535329].
Evidence BInsomnia in patients with depression or OCD
A pilot randomized double-blind placebo-controlled trial investigated the use of V. odorata syrup as an add-on therapy for sleep quality [PMID:32073874].
Evidence B
Safety & adverse effects
V. odorata oil was reported as safe for fever control in febrile neutropenic children [PMID:31250761]. In B16F10 murine melanoma cells, the extract showed no cytotoxicity [PMID:28392894].
Evidence summary
Evidence ranges from high-level systematic reviews for insomnia (Level A) and several randomized controlled trials for fever and sleep (Level B), to in vitro and animal studies regarding antioxidant, anti-cancer, and antimicrobial properties (Level D).
PubMed sources
1.PMID: 37694059 (2023) — Detection of Coumarin Derivatives of Viola odorata Cultivated in Iraq. · Journal of pharmacy & bioallied sciences
2.PMID: 35487935 (2022) — Procyanidin C1 from Viola odorata L. inhibits Na+,K+-ATPase. · Scientific reports
3.PMID: 36838663 (2023) — Commercially Available Viola odorata Oil, Chemical Variability and Antimicrobial Activity. · Molecules (Basel, Switzerland)
4.PMID: 35734476 (2022) — The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis. · Frontiers in neurology
5.PMID: 31812106 (2020) — An overview of acyclotides: Past, present and future.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
A randomized triple-blind controlled trial assessed the effects of V. odorata syrup (5ml twice daily) on sleep quality [PMID:38177831].
· Phytochemistry
6.PMID: 37099442 (2023) — Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans. · Journal of natural products
7.PMID: 35115562 (2022) — The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite. · Scientific reports
8.PMID: 41960579 (2026) — The genome sequence of the sweet violet, Viola odorata L. (Malpighiales: Violaceae). · Wellcome open research
9.PMID: 28948657 (2017) — A Critical Review on Phytochemistry, Pharmacology of Viola odorata L. and Related Multipotential Products in Traditional Persian Medicine. · Phytotherapy research : PTR
10.PMID: 27516984 (2016) — Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species. · Avicenna journal of phytomedicine
11.PMID: 34981485 (2021) — Role of Herbal Medicines in the Management of Brain Injury. · Advances in experimental medicine and biology
12.PMID: 38628881 (2023) — Herbal Treatment of COPD and Asthma According to Persian Medicine: a Review of Current Evidence. · Tanaffos
13.PMID: 36107799 (2023) — Cyclic cystine knot and its strong implication on the structure and dynamics of cyclotides. · Proteins
14.PMID: 35591648 (2022) — Impact of Drying Conditions on Antioxidant Activity of Red Clover (Trifolium pratense), Sweet Violet (Viola odorata) and Elderberry Flowers (Sambucus nigra). · Materials (Basel, Switzerland)
15.PMID: 35490427 (2022) — Native Iranian Medicinal Plants with Anti-Vaginal Infection Properties: A Systematic Review. · Infectious disorders drug targets
16.PMID: 25763239 (2014) — Efficacy of Viola odorata in Treatment of Chronic Insomnia. · Iranian Red Crescent medical journal
17.PMID: 35292687 (2022) — Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens. · Scientific reports
18.PMID: 33490239 (2020) — In Silico Prediction of the Mode of Action of Viola odorata in Diabetes. · BioMed research international
19.PMID: 36535329 (2023) — Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial. · Journal of ethnopharmacology
20.PMID: 38177831 (2024) — Effects of Viola odorata syrup on sleep quality in menopausal women: a randomized, triple-blind, controlled trial. · Sleep & breathing = Schlaf & Atmung
21.PMID: 29775777 (2018) — Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism. · Fitoterapia
22.PMID: 30292877 (2018) — Production of bioactive cyclotides in somatic embryos of Viola odorata. · Phytochemistry
23.PMID: 28392894 (2017) — Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells. · Iranian journal of basic medical sciences
24.PMID: 20564007 (2010) — A new "era" for cyclotide sequencing. · Biopolymers
25.PMID: 32073874 (2020) — Effects of Viola odorata as an Add-On Therapy on Insomnia in Patients with Obsession or Depression: A Pilot Randomized Double-Blind Placebo-Controlled Trial. · Journal of alternative and complementary medicine (New York, N.Y.)
26.PMID: 32056127 (2020) — Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells. · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
27.PMID: 32507426 (2020) — Efficacy of Sweet Violet (Viola odorata) flower oil on the symptoms of adults with allergic rhinitis: A double-blind randomized placebo-controlled clinical trial. · Complementary therapies in medicine
28.PMID: 31250761 (2020) — The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial. · Current drug discovery technologies
29.PMID: 30387611 (2018) — Discovery and Characterization of Cyclotides from Rinorea Species. · Journal of natural products
30.PMID: 38679329 (2024) — Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor. · The Journal of biological chemistry