PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 25 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous ethanolic seed extract showed in vitro anti-inflammatory activity (IC50 = 26.01 ± 0.85 µg/ml) and in vivo anti-arthritic activity in antigen-induced arthritis rats [PMID:41495193]
Seed oils exhibit anti-proliferative effects on hormone-dependent (MCF-7) and cytotoxic effects on hormone-independent (MDA-MB-231) breast cancer cells [PMID:35129016]
Root extracts demonstrate antibacterial activity against various strains, including those from Staphylococcus, Enterococcus, Pseudomonas, Escherichia, Klebsiella, and Salmonella genera [PMID:9533435, PMID:20161933]
Root extracts show fungistatic and fungicidal activity against Candida spp. [PMID:8786762]
Root extracts contain compounds with antimicrobial activity against H. pylori [PMID:8874968]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 26944235 (2016) — Ximenia caffra Sond. (Ximeniaceae) in sub-Saharan Africa: A synthesis and review of its medicinal potential. · Journal of ethnopharmacology
- 2.PMID: 40012125 (2025) — Ximenia caffra Sond. the magic wild indigenous plant that offers immense contribution as food and medicine. · Natural product research
- 3.PMID: 35129016 (2022) — Differential Expression of Platelet Activation Markers, CD62P and CD63, after Exposure to Breast Cancer Cells Treated with Kigelia Africana, Ximenia Caffra and Mimusops Zeyheri Seed Oils In Vitro. · Nutrition and cancer
- 4.PMID: 41495193 (2026) — In vitro anti-inflammatory potential and in vivo anti-arthritis activities of Ximenia caffra extract on antigen-induced arthritis in rats. · Scientific reports
- 5.PMID: 26344703