PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 8 PubMed articles · model: gemma4:31b
Summary
Xylia xylocarpa is a medicinal plant with reported neuroprotective potential and anti-cholinesterase properties [PMID:27493681, PMID:42280768].
Background
Xylia xylocarpa is a drought-deciduous tree found in monsoonal tropical dry forests, such as those in Thailand [PMID:20581012, PMID:24336612]. It belongs to the Caesalpinioideae subfamily [PMID:33366732].
Active compounds
The plant contains total free phenolics, tannins, L-Dopa, and phytic acid in its seed materials [PMID:24293686]. Phytochemical analysis of Vietnamese X. xylocarpa identified a new hopan-type triterpenoid, (3β)-hopan-3-ol-28,22-olide, along with twenty other compounds [PMID:27493681]. Senbusine A has been identified as a potential lead candidate for GCase stabilization [PMID:42280768].
Mechanism of action
Methanolic extracts and specific isolated compounds exhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity [PMID:27493681]. Certain compounds are predicted to act as allosteric stabilizers of glucocerebrosidase (GCase) [PMID:42280768].
Clinical evidence
Evidence DMemory deficit (scopolamine-induced)
Methanolic extract of Xylia xylocarpa (MEXX) showed memory improving effects [PMID:27493681]
Evidence DParkinson's Disease
Computational analysis identified compounds, specifically Senbusine A, as potential GCase stabilizers for therapeutic strategy [PMID:42280768]
Evidence summary
The current evidence is limited to phytochemical profiling, computational docking, and in vivo animal/laboratory models (Level D); there are no human clinical trials provided.
PubMed sources
- 1.PMID: 33366732 (2020) — The complete chloroplast genome sequence of Xylia xylocarpa. · Mitochondrial DNA. Part B, Resources
- 2.PMID: 24336612 (2014) — Photoprotection of evergreen and drought-deciduous tree leaves to overcome the dry season in monsoonal tropical dry forests in Thailand. · Tree physiology
- 3.PMID: 27493681 (2016) — Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa. · Chemistry Central journal
- 4.PMID: 42280768 (2026) — Structure-Based Identification of Allosteric Glucocerebrosidase Stabilizers from Xylia xylocarpa (Roxb.) Taub. for Parkinson's Disease Using LC-MS Profiling and Computational Analysis. · Plants (Basel, Switzerland)
- 5.PMID: 20581012 (2010) — Seasonal variations of gas exchange and water relations in deciduous and evergreen trees in monsoonal dry forests of Thailand.