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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Eclipta alba (also known as Bhringaraj) is a medicinal herb used in Asian and African traditional medicines for its diverse pharmacological properties, including neuroprotective, hepatoprotective, and antimicrobial effects [PMID:31116703, PMID:27355071, PMID:34827736].
Background
Eclipta alba (L.) Hassk. is a small branched perennial herb and weed distributed globally, particularly in tropical and subtropical regions [PMID:24191336, PMID:38202343, PMID:34827736]. It is widely utilized in Ayurvedic, Unani, and other traditional medicinal systems [PMID:24191336, PMID:27355071].
Traditional uses
Traditional uses include the treatment of gastrointestinal and respiratory tract disorders (including asthma), fever, liver disorders (including jaundice), skin disorders, spleen enlargement, cuts, wounds, and hair loss or graying of hair [PMID:27355071, PMID:34827736].
The herb exhibits antioxidant activity by scavenging free radicals and reducing oxidative stress [PMID:39926801]. In murine models of leukemia, it has shown immunomodulation of the NF-kB family and IL-1β expressional profile [PMID:34420458]. In adipocyte studies, the ethyl acetate fraction inhibited mitotic clonal expansion and caused cell cycle arrest in G1 and S phases [PMID:29032341].
Clinical evidence
Evidence CCognitive deficits and seizures
Extracts improve cognitive deficits and attenuate epileptic seizures, with Eclalbasaponin II and luteolin implicated in these effects [PMID:31116703]
Evidence DCerebral ischemia/reperfusion injury
Hydroalcoholic extract showed cerebroprotective and antioxidant effects in rats by mitigating oxidative stress [PMID:22951390]
Evidence DObesity/Dyslipidemia
Ethyl acetate fraction inhibited adipocyte differentiation and showed anti-dyslipidemic activity in hamsters [PMID:29032341]; acetone fraction showed anti-lipase activity in zebrafish [PMID:42291152]
Evidence DLiver Injury
A preparation containing E. alba and curcumin normalized lipid accumulation and serum bilirubin in CCl4-induced fatty liver rat models [PMID:22557595]
Evidence CDiabetes
E. alba extracts have shown promising effects as enzyme inhibitors for antidiabetic therapy [PMID:30417583]
Safety & adverse effects
Eclipta alba has been identified as a potential antigen causing air-borne contact dermatitis in some sensitive patients [PMID:28150592].
Evidence summary
The current evidence is primarily based on review articles (Level C) and preclinical animal or in vitro studies (Level D). There is a lack of human clinical trials (Level B) or meta-analyses (Level A) in the provided data.
PubMed sources
1.PMID: 31116703 (2019) — Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk. · Journal of complementary & integrative medicine
2.PMID: 27355071 (2014) — Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae). · International scholarly research notices
3.PMID: 38202343 (2023) — Unlocking Therapeutic Potential: Comprehensive Extraction, Profiling, and Pharmacological Evaluation of Bioactive Compounds from Eclipta alba (L.) Hassk. for Dermatological Applications. · Plants (Basel, Switzerland)
4.PMID: 26125878 (2015) — Improving plant transformation using Agrobacterium tumefaciens. · Genetics and molecular research : GMR
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications.
· Materials science & engineering. C, Materials for biological applications
6.PMID: 39926801 (2024) — Antioxidant Effects of E. alba: A Narrative Review. · Journal of pharmacy & bioallied sciences
7.PMID: 34827736 (2021) — Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities. · Biomolecules
8.PMID: 30909408 (2019) — Antifungal Activity of Eclipta alba Metabolites against Sorghum Pathogens. · Plants (Basel, Switzerland)
9.PMID: 35488419 (2022) — Light and scanning electron microscopic comparative studies of geminivirus infected and healthy Eclipta alba (L.). · Microscopy research and technique
10.PMID: 30417583 (2019) — Enzymes inhibitors from natural sources with antidiabetic activity: A review. · Phytotherapy research : PTR
11.PMID: 10821961 (2000) — Medicinal plants used for dogs in Trinidad and Tobago. · Preventive veterinary medicine
13.PMID: 35179846 (2021) — Parasiticidal effects of Eclipta alba and Arctium lappa extracts against Ichthyophthirius multifiliis. · Polish journal of veterinary sciences
14.PMID: 34420458 (2022) — Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by Eclipta alba in murine model. · International journal of environmental health research
15.PMID: 22557595 (1987) — A new receipt for liver injury. · Ancient science of life
16.PMID: 42291152 (2026) — Phytochemical profiling and anti-obesity effects of Eclipta alba (L.) Hassk. powder in diet-Induced obese zebrafish model. · 3 Biotech
17.PMID: 37439007 (2023) — Medicinal plant molecules against hepatitis C virus: Current status and future prospect. · Phytotherapy research : PTR
18.PMID: 34228958 (2021) — Exploration of plant products and phytochemicals against aflatoxin toxicity in broiler chicken production: Present status. · Toxicon : official journal of the International Society on Toxinology
19.PMID: 36836257 (2023) — Immunomodulatory Potency of Eclipta alba (Bhringaraj) Leaf Extract in Heteropneustes fossilis against Oomycete Pathogen, Aphanomyces invadans. · Journal of fungi (Basel, Switzerland)
21.PMID: 28150592 (1986) — Air-borne Contact Dermatitis in Varanasi. · Indian journal of dermatology, venereology and leprology
22.PMID: 24191336 (2013) — Accentuating the prodigious significance of Eclipta alba - an inestimable medicinal plant. · Pakistan journal of pharmaceutical sciences
23.PMID: 33321899 (2020) — Indian Medicinal Herbs and Formulations for Alzheimer's Disease, from Traditional Knowledge to Scientific Assessment. · Brain sciences
24.PMID: 11491397 (2001) — Eclalbatin, a triterpene saponin from Eclipta alba. · Journal of Asian natural products research
25.PMID: 16054316 (2005) — Neuropharmacological profile of Eclipta alba (Linn.) Hassk. · Journal of ethnopharmacology
26.PMID: 22951390 (2012) — Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats. · Phytomedicine : international journal of phytotherapy and phytopharmacology
27.PMID: 35694813 (2023) — Identification of phytochemicals from Eclipta alba and assess their potentiality against Hepatitis C virus envelope glycoprotein: virtual screening, docking, and molecular dynamics simulation study. · Journal of biomolecular structure & dynamics
28.PMID: 37993758 (2024) — Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231). · Molecular biotechnology
29.PMID: 36034950 (2022) — In Silico and In Vitro Screening Constituents of Eclipta alba Leaf Extract to Reveal Antimicrobial Potential. · Evidence-based complementary and alternative medicine : eCAM
30.PMID: 37506606 (2023) — Comparision of traditional and laboratory methods of sulphur processing. · Journal of Ayurveda and integrative medicine