PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 10 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Extracts from the bark exhibited potent activity against strains of MRSA resistant to clinically useful antibiotics [PMID:12672160]
Hydroxy-α-sanshool caused selective attenuation of mechanical sensitivity under naive and inflammatory conditions in mice [PMID:23652591]
A standardized composition including Z. clava-herculis extracts was screened for its ability to reduce cellular lipid accumulation and improve microcirculation [PMID:29263624]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 8836382 (1996) — Neuromuscular effects of toxins isolated from southern prickly ash (Zanthoxylum clava-herculis) bark. · American journal of veterinary research
- 2.PMID: 29263624 (2017) — A Standardized Composition Comprised of Extracts from Rosmarinus officinalis, Annona squamosa and Zanthoxylum clava-herculis for Cellulite. · Pharmacognosy research
- 3.PMID: 12672160 (2003) — Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA). · Phytotherapy research : PTR
- 4.PMID: 20420327 (2010) — Seasonal variation in the leaf essential oil composition of Zanthoxylum clava-herculis growing in Huntsville, Alabama. · Natural product communications
- 5.PMID: 23652591 (2013) — A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.