This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Zingiber montanum (also known as Phlai or Bangle) is a medicinal herb from the Zingiberaceae family used primarily for its anti-inflammatory, analgesic, and antimicrobial properties [PMID:33921835, 32735595].
Background
Zingiber montanum (Z. montanum), also referred to as Zingiber cassumunar Roxb., is a medicinal and ornamental herb found in tropical regions, particularly Southeast Asia [PMID:32735595, 40380132]. It is known as "Plai" in Thailand, "Bangle" in Indonesia, and "Bulei" in China [PMID:33921835].
Traditional uses
Traditionally, the rhizomes have been used to treat inflammation, pain, respiratory problems [PMID:33921835], bruises, sprains, and musculoskeletal pain [PMID:29154071]. It has also been used as an anti-asthmatic drug in Thai traditional medicine [PMID:25543044, 25840633] and to ameliorate peptic ulcers in northern Bangladesh [PMID:22366683].
Active compounds
Key constituents include phenylbutenoids, curcuminoids, and essential oils [PMID:33921835]. Specific identified compounds include sabinene, terpinen-4-ol, gamma-terpinene [PMID:32019210, 37202876], curcumin, beta-sitosterol, and lauric acid [PMID:40141705], as well as (E)-1-(3,4-dimethoxyphenyl)but-1-ene, (E)-1-(3,4-dimethoxyphenyl)butadiene, and zerumbone [PMID:1804548].
Mechanism of action
The herb demonstrates anti-inflammatory effects by inhibiting the phosphorylation of ERK1/2, p38, and JNK [PMID:23278498], and suppressing PMA-induced MUC2 and MUC5AC expression via ERK inhibition [PMID:25543044]. It also inhibits MMP-9 direct activation and expression [PMID:25840633] and targets NF-kappaB, Akt/MAPK, and caspase-3 pathways [PMID:40380132].
Clinical evidence
Evidence BAllergic Rhinitis
Phlai capsules (100 mg and 200 mg) improved reflective total five symptom scores (rT5SS) compared to placebo [PMID:37302097]. 200 mg capsules significantly reduced nasal IL-5, IL-13, and eosinophil counts [PMID:37302093].
Evidence AMusculoskeletal Pain / Sprains
14% Plai cream showed a strong trend of benefit in pain reduction for muscle pain and ankle sprains [PMID:29154071]. 14% Plai cream substantially reduced delayed onset muscle soreness (DOMS) by 82% compared to placebo [PMID:26988432].
Evidence BPainful Diabetic Neuropathy
Topical application of 15% w/w Plai balm significantly reduced mean pain scores compared to placebo at weeks 2 and 4 [PMID:39220605].
Evidence BMyofascial Pain Syndrome
Phlai spray cool formula (PSCF) showed comparable reductions in pain intensity and improvements in neck disability index and cervical range of motion compared to diclofenac spray [PMID:40141705].
Evidence BCognition
Inhalation of a phlai-containing essential oil blend was investigated for acute cognitive effects in healthy adults [PMID:41614069].
Safety & adverse effects
In zebrafish embryos and carp PBMC assays, no cytotoxic effect was observed with cassumunar ginger oil concentrations less than 50 microg/mL [PMID:32019210].
Evidence summary
Evidence is strongest for topical use in musculoskeletal pain (Systematic Review/RCTs). There is emerging clinical evidence (RCTs) for oral use in allergic rhinitis and topical use for diabetic neuropathy and myofascial pain. Preclinical data support broad anti-inflammatory and antimicrobial activities.
PubMed sources
1.PMID: 33921835 (2021) — Phytochemicals and Bioactivities of Zingiber cassumunar Roxb. · Molecules (Basel, Switzerland)
2.PMID: 37302093 (2024) — Inhibitory effect of Zingiber cassumunar Roxb. (Phlai) on nasal cytokine productions and eosinophilic recruitment in patients with allergic rhinitis. · Asian Pacific journal of allergy and immunology
3.PMID: 29154071 (2017) — Clinical effects of Zingiber cassumunar (Plai): A systematic review. · Complementary therapies in medicine
5.PMID: 34485774 (2021) — Repellent, larvicidal and adulticidal activities of essential oil from Dai medicinal plant Zingiber cassumunar against Aedes albopictus.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 25543044 (2014) — Crude ethanolic extracts of Zingiber cassumunar ROXB. inhibit PMA-induced MUC2 and MUC5AC expression via ERK inhibition in human airway epithelial cells. · Asian Pacific journal of allergy and immunology
7.PMID: 39220605 (2023) — Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial. · F1000Research
8.PMID: 32735595 (2020) — Complete chloroplast genomes of Zingiber montanum and Zingiber zerumbet: Genome structure, comparative and phylogenetic analyses. · PloS one
9.PMID: 31618177 (2019) — Acute effects of essential oil blend containing phlai oil on mood among healthy male volunteers: Randomized controlled trial. · Journal of complementary & integrative medicine
10.PMID: 28546949 (2017) — Properties of macerated herbal oil. · BioImpacts : BI
11.PMID: 25840633 (2015) — Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells. · Asian Pacific journal of allergy and immunology
12.PMID: 11237173 (2000) — Phenolic antioxidants from herbs and spices. · BioFactors (Oxford, England)
13.PMID: 28162962 (2017) — In vitro synergistic antibacterial activity of the essential oil from Zingiber cassumunar Roxb against extensively drug-resistant Acinetobacter baumannii strains. · Journal of infection and public health
14.PMID: 32596307 (2020) — The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. · BioMed research international
15.PMID: 40380132 (2025) — Phytochemical analysis and biological effects of Zingiber cassumunar extract and three phenylbutenoids: targeting NF-κB, Akt/MAPK, and caspase-3 pathways. · BMC complementary medicine and therapies
16.PMID: 34056774 (2022) — Mass spectral analysis of secondary metabolites from Zingiber montanum rhizome extract using UHPLC-HR-ESI-QTOF-MS/MS. · Phytochemical analysis : PCA
17.PMID: 23278498 (2013) — Inhibitory effect of Zingiber cassumunar extracts on lipopolysaccharide-induced cyclooxygenase-2 and matrix metalloproteinase expression in human gingival fibroblasts. · Journal of periodontal research
18.PMID: 41614069 (2025) — Inhalation of phlai-containing essential oil enhances cognition: a comparison with olive oil in healthy adults. · Frontiers in pharmacology
19.PMID: 37302097 (2026) — Phase III study of Phlai capsules in the treatment of allergic rhinitis: A randomized, double-blind, placebo-controlled trial. · Asian Pacific journal of allergy and immunology
20.PMID: 26988432 (2016) — Effects of Zingiber cassumunar (Plai cream) in the treatment of delayed onset muscle soreness. · Journal of integrative medicine
21.PMID: 29103416 (2017) — Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients: a randomized, three-way crossover study. · Journal of integrative medicine
22.PMID: 35883772 (2022) — Bioactive Compounds from the Zingiberaceae Family with Known Antioxidant Activities for Possible Therapeutic Uses. · Antioxidants (Basel, Switzerland)
23.PMID: 37202876 (2023) — Essential Oil of Zingiber cassumunar Roxb. and Zingiber officinale Rosc.: A Comparative Study on Chemical Constituents, Antibacterial Activity, Biofilm Formation, and Inhibition of Pseudomonas aeruginosa Quorum Sensing System. · Chemistry & biodiversity
24.PMID: 32019210 (2020) — Phytochemical and Safety Evaluations of Volatile Terpenoids from Zingiber Cassumunar Roxb. On Mature Carp Peripheral Blood Mononuclear Cells and Embryonic Zebrafish. · Molecules (Basel, Switzerland)
25.PMID: 33519275 (2021) — Potential bangle (Zingiber montanum J.König) rhizome extract as a supplement to prevent and reduce symptoms of Covid-19. · Saudi journal of biological sciences
26.PMID: 40141705 (2025) — Efficacy of Phlai (Zingiber montanum) Spray Cool Formula in Managing Upper Trapezius Myofascial Pain Syndrome: A Randomized Controlled Trial. · Life (Basel, Switzerland)
27.PMID: 22366683 (2012) — Antiulcer principle from Zingiber montanum. · Journal of ethnopharmacology
28.PMID: 1804548 (1991) — Anti-inflammatory effect of Zingiber cassumunar Roxb. and its active principles. · Chemical & pharmaceutical bulletin