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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Echinacea may interfere with methotrexate's immunosuppressive effects and potentially increase hepatotoxicity risk with prolonged use.
Immune stimulation may oppose methotrexate's immunosuppressive action. Both may affect liver function.
Source: Natural Medicines Database · Reviewed April 2026
Echinacea + Methotrexate: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Echinacea may interfere with methotrexate's immunosuppressive effects and potentially increase hepatotoxicity risk with prolonged use.
Immune stimulation may oppose methotrexate's immunosuppressive action. Both may affect liver function.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.