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Severe· moderate-evidence
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Combining ginseng with MAO inhibitors can cause headaches, tremors, and manic episodes.
Ginseng may have stimulatory and serotonergic effects that interact with MAO inhibition.
Source: Natural Medicines Database · Reviewed April 2026
Ginseng + Phenelzine (Nardil) - MAOI: high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Combining ginseng with MAO inhibitors can cause headaches, tremors, and manic episodes.
Ginseng may have stimulatory and serotonergic effects that interact with MAO inhibition.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.