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Severe· moderate-evidence
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Caffeine in green tea inhibits CYP1A2, the main enzyme clearing clozapine, and can raise clozapine blood levels — increasing seizure and toxicity risk. Do not change intake without prescriber supervision and blood monitoring.
Caffeine is a CYP1A2 inhibitor; reduced clozapine clearance raises serum concentrations of a drug with a narrow therapeutic index and dose-dependent seizure risk.
Source: Clinical Studies · Reviewed September 2026
Green Tea + Clozapine: high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Caffeine in green tea inhibits CYP1A2, the main enzyme clearing clozapine, and can raise clozapine blood levels — increasing seizure and toxicity risk. Do not change intake without prescriber supervision and blood monitoring.
Caffeine is a CYP1A2 inhibitor; reduced clozapine clearance raises serum concentrations of a drug with a narrow therapeutic index and dose-dependent seizure risk.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.