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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Holy basil may enhance and prolong the sedative effects of barbiturates.
Holy basil's sedative compounds may create additive CNS depression with barbiturates.
Source: Clinical Studies · Reviewed April 2026
Holy Basil + Pentobarbital: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Holy basil may enhance and prolong the sedative effects of barbiturates.
Holy basil's sedative compounds may create additive CNS depression with barbiturates.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.