This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
Melissa officinalis
Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Lemon balm may enhance sedative effects of barbiturates and other CNS depressants.
Rosmarinic acid and other constituents have GABAergic activity that creates additive sedation.
Source: Natural Medicines Database · Reviewed April 2026
Lemon Balm + Sedatives and Barbiturates: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Lemon balm may enhance sedative effects of barbiturates and other CNS depressants.
Rosmarinic acid and other constituents have GABAergic activity that creates additive sedation.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.