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Passiflora incarnata
Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Passionflower may enhance sedative effects of benzodiazepines and other CNS depressants.
Chrysin and other flavonoids bind to GABA-A receptors, creating additive sedation with benzodiazepines.
Source: Natural Medicines Database · Reviewed April 2026
Passionflower + Sedatives and Benzodiazepines: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Passionflower may enhance sedative effects of benzodiazepines and other CNS depressants.
Chrysin and other flavonoids bind to GABA-A receptors, creating additive sedation with benzodiazepines.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.