Boneset Herb vs Spilanthes African

Side-by-side comparison of medicinal herbs

Herb

Boneset Herb

Eupatorium perfoliatum

Immune Support

Acmella caulirhiza

Immune Support

Boneset Herb

❌ Not recommended in pregnancy

❌ Not recommended while nursing

Spilanthes African

❌ Not recommended in pregnancy

❌ Not recommended while nursing

Description

Eastern North American herb used by numerous Native American tribes as the definitive treatment for influenza and bone-breaking fever pain.

African species of the toothache plant used across sub-Saharan Africa for toothache, immune support, and as a general antimicrobial.

Active Compounds

eupafolin, echinacoside, polysaccharides, flavonoids

spilanthol, N-isobutylamides, flavonoids, polyacetylenes

Traditional Uses

Treat influenza bone pain, Fever and infection treatment, Immune stimulant, Cherokee and Iroquois medicine

Toothache treatment, Immune stimulant, Antimicrobial infections, Traditional African medicine

Modern Uses

Immune stimulant, Antipyretic, Antiviral, Anti-inflammatory

Local anesthetic, Immune stimulant, Antimicrobial, Anti-inflammatory

Adult Dosage

3-5g dried herb as hot tea or 3ml tincture 3x daily

1-3ml tincture or 2g herb tea 3x daily

Contraindications

Autoimmune conditions, Pregnancy, Liver disease (PAs trace)

Pregnancy, Autoimmune diseases

Side Effects

Nausea at high doses, Hepatotoxicity risk with excess

Excessive salivation, GI upset

Drug Interactions

0 known interactions

Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals

Sources: WHO Monographs · NCCIH · PubMed · Commission E