Coleus vs Berberine

Coleus forskohlii is a tropical plant in the mint family, native to India, Nepal, and Thailand. It has been used in Ayurvedic medicine for centuries for heart and lung conditions. Its primary compound, forskolin, directly activates adenylate cyclase, an enzyme fundamental to many cellular processes.

Berberine is an alkaloid found in several plants including barberry, goldenseal, and Oregon grape. It has been used in Ayurvedic and Chinese medicine for over 3,000 years. Modern research has revealed it to be one of the most potent natural compounds for metabolic health, with effects rivaling some pharmaceutical drugs.

Forskolin, Rosmarinic acid, Flavonoids, Diterpenoids, Beta-sitosterol

Berberine, Palmatine, Jatrorrhizine, Columbamine, Berbamine

Heart tonic, Respiratory support, Digestive aid, Eye pressure treatment, Weight management

Digestive aid, Antimicrobial, Fever treatment, Eye infections, Diarrhea treatment

Glaucoma (eye drops), Asthma, Weight management, Hypothyroidism support, Cardiovascular health

Type 2 diabetes and blood sugar regulation, Cholesterol management, PCOS support, Gut health and SIBO, Weight management

250mg standardized extract (10% forskolin) 2 times daily

500mg 2-3 times daily with meals (total 1000-1500mg daily)

Low blood pressure, Concurrent blood pressure medications, Bleeding disorders, Pre-surgery, Peptic ulcers

Pregnancy, Breastfeeding, Neonates and infants, Concurrent diabetes medications (risk of hypoglycemia), Low blood pressure

Low blood pressure, Increased heart rate, GI upset, Headache, Flushing

GI upset, Constipation, Diarrhea, Flatulence, Nausea, Cramping