Hypericum Maculatum vs St. John's Wort

Perennial herb of European meadows closely related to common St John's Wort, used in Central European folk medicine for similar nervous system conditions.

St. John's Wort is a flowering plant that has been used medicinally since ancient Greece. It is best known for its use in treating mild to moderate depression, where clinical evidence supports its efficacy comparable to some conventional antidepressants. It is named for its traditional harvest on St. John's Day.

hypericin, pseudohypericin, hyperforin, flavonoids, xanthones

Hypericin, Hyperforin, Adhyperforin, Flavonoids, Xanthones

mild depression, nervous conditions, wound healing, anxiety, neuralgia

Depression treatment, Wound healing, Nerve pain relief, Anti-inflammatory, Sedative

antidepressant, anxiolytic, wound healing, anti-inflammatory

Mild to moderate depression, Seasonal affective disorder, Anxiety, Nerve pain, Menopausal symptoms

4–6g dried herb as tea 3x daily or 300mg extract

300mg extract (0.3% hypericin) 3 times daily

SSRIs, cyclosporine, contraceptives, pregnancy, photosensitivity

Concurrent use with SSRIs or MAOIs, Bipolar disorder, Schizophrenia, Organ transplant recipients, HIV patients on antiretrovirals

photosensitivity, serotonin syndrome, drug interactions

Photosensitivity, Dry mouth, Dizziness, GI upset, Fatigue, Restlessness