Abutilon indicum (Abutilon indicum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Abutilon indicum work for nerve pain?

Abutilon indicum contains active compounds including flavonoids, alkaloids, and saponins that are believed to exert analgesic and anti-inflammatory effects. The mucilage content provides demulcent properties that may soothe irritated tissues. As a component of Dashamoola (ten roots) in Ayurveda, it is traditionally thought to support the nervous system and reduce vata dosha imbalances associated with nerve pain. Evidence level: C (preliminary evidence).

Does Abutilon indicum interact with any medications?

There is limited clinical data on drug interactions for Abutilon indicum. Due to its mucilage content, it may potentially affect the absorption of orally administered medications if taken simultaneously. Patients taking medications for diabetes, blood pressure, or neurological conditions should consult a healthcare provider before use. The herb's effects on drug-metabolizing enzymes have not been well studied. Evidence level: C (preliminary evidence).

What is the recommended dosage for Abutilon indicum?

Traditional Ayurvedic practice suggests 3-5 grams of dried herb prepared as a tea, taken three times daily. Alternatively, 500 mg of powdered herb can be taken twice daily. Dosage may vary based on the specific formulation and condition being addressed. Always follow product label instructions or consult a qualified practitioner, as standardized preparations may differ. Evidence level: C (traditional use).

Is Abutilon indicum safe during pregnancy?

Abutilon indicum is contraindicated during pregnancy and should be avoided. Traditional Ayurvedic sources classify this herb as unsafe for pregnant women, though specific mechanisms of harm are not well documented in modern research. Women who are pregnant, planning pregnancy, or breastfeeding should not use this herb. Consult a healthcare provider for appropriate alternatives. Evidence level: C (traditional contraindication).

What is Abutilon indicum used for in Ayurveda?

Abutilon indicum is traditionally used in Ayurveda for nerve pain, weakness, urinary conditions, joint pain, and wound healing. As one of the ten roots in Dashamoola formulation, it is valued for supporting the nervous system and musculoskeletal health. The herb's mucilage content provides soothing properties for urinary and digestive tissues. Modern research on these uses remains preliminary. Evidence level: C (limited clinical evidence).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Abutilon indicum, also known as Atibala or Country mallow, is a perennial shrub of the Malvaceae family used in traditional medicine for its anti-inflammatory, analgesic, and antioxidant properties [PMID:37303858, PMID:36235451, PMID:20645814].

Contexte

Abutilon indicum is a perennial shrub found in many Asian countries, including India, Sri Lanka, and parts of Malaysia [PMID:36235451, PMID:38186405]. It is widely utilized within the Ayurveda system of medicine [PMID:37303858].

Usages traditionnels

Traditionally used to treat inflammation, discomfort, urethral infections, gout, bronchitis, diabetes, piles, constipation, chronic cystitis, gonorrhea, gleet, pregnancy-related problems, jaundice, and leprosy [PMID:36235451, PMID:38021797, PMID:39097211, PMID:34697741].

Composés actifs

Identified constituents include alkaloids, flavonoids, sesquiterpene lactones, gallic acid, β-sitosterols, geraniol, caryophyllene, and eugenol [PMID:38186405, PMID:34697741, PMID:10798248]. Specific isolated compounds include abutilin A and (R)-N-(1'-methoxycarbonyl-2'-phenylethyl)-4-hydroxybenzamide [PMID:18636384], as well as methyl trans-p-coumarate, methyl caffeate, syringic acid, and pinellic acid [PMID:25422029].

Mécanisme d'action

The ethanolic leaf extract has demonstrated anti-inflammatory effects by targeting the 5-lipoxygenase enzyme [PMID:38186405]. It may also exhibit insulin-like character to inhibit lipolysis and stimulate adipogenesis activity [PMID:36684487].

Preuves cliniques

Preuve DDiabetic neuropathy

A study of 33 patients receiving a decoction of Atibala-mula (10g twice daily) and Bhumyamalaki Churna (3g twice daily) for 30 days was conducted to assess sensory perception and symptoms like numbness and pain [PMID:22529650].

Preuve DInflammation

Ethanolic extract of the whole plant showed significant dose-dependent anti-inflammatory activity in Wistar albino rats, comparable to ibuprofen [PMID:21999427].

Preuve DPain (Analgesia)

Eugenol isolated from A. indicum exhibited significant inhibition of acetic acid-induced writhing in mice [PMID:10798248].

Preuve DAnxiety and Depression

Crude methanolic extract of leaves and bark exhibited anxiolytic and antidepressant potential in mice models [PMID:34697741].

Preuve DLead-induced reproductive toxicity

Methanolic root extract mitigated the toxic impact of lead on the reproductive system of male Wistar rats [PMID:30714201].

Sécurité et effets indésirables

A study on the methanolic extract of A. indicum seed (MAS) aimed to document in-vitro cytotoxicity, mutagenicity, and in-vivo acute and sub-acute toxicity [PMID:39097211].

Grossesse et allaitement

Traditionally, A. indicum seed powder is consumed to treat pregnancy-related problems [PMID:39097211].

Synthèse des preuves

The current evidence is primarily based on in-vitro studies, animal models (mice/rats), and a small-scale clinical observation. There is a lack of high-level clinical trials (RCTs) or systematic reviews to confirm efficacy in humans.

Sources PubMed

1.PMID: 37303858 (2021) — Pharmacognostical and phytochemical studies of Atibala (Abutilon indicum [Linn.] sweet) fruit. · Ayu
2.PMID: 18636384 (2008) — Chemical constituents from Abutilon indicum. · Journal of Asian natural products research
3.PMID: 22529650 (2011) — Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy. · Ayu
4.PMID: 38021797 (2023) — Phytochemical Analysis and Antioxidant Evaluation of the Ethanolic Extract of the Leaves of Abutilon indicum. · Cureus
5.PMID: 36235451 (2022) — The Structural, Biological, and In-Silico Profiling of Novel Capryloyl Tetra-Glucoside and Aliphatic Ester Constituents from the Abutilon indicum Offers New Perspectives on the Treatment of Pain and Inflammation. · Plants (Basel, Switzerland)

Abutilon indicum

Sources et citations

Calculer une dose sûre de Abutilon indicum

Sumac Bark

Aster amellus

Ximenia Americana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Abutilon indicum

Sources et citations

Calculer une dose sûre de Abutilon indicum

Plantes associées

Sumac Bark

Aster amellus

Ximenia Americana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales