Question 1

How does Calotropis gigantea work medicinally?

Accepted Answer

Calotropis gigantea contains cardiac glycosides, primarily calotropin and calactin, which inhibit sodium-potassium ATPase enzymes. This mechanism produces cardiotonic effects but also underlies the plant's significant toxicity profile. The latex contains proteolytic enzymes and compounds that may explain its traditional topical use for skin diseases and wound healing. Evidence Level: C (preclinical studies supporting mechanism).

Question 2

Does Calotropis gigantea interact with heart medications?

Accepted Answer

Calotropis gigantea poses serious interaction risks with cardiac medications due to its cardiac glycoside content. Concurrent use with digoxin, beta-blockers, calcium channel blockers, or diuretics may cause additive cardiac toxicity, arrhythmias, or electrolyte imbalances. The herb should never be combined with prescription heart medications. Evidence Level: C (theoretical interactions based on pharmacology).

Question 3

What is the safe dosage for Calotropis gigantea?

Accepted Answer

Traditional Ayurvedic practice applies Calotropis gigantea latex topically for skin conditions. Internal use of 1-2g bark powder has been documented but requires extreme caution. Due to cardiac glycoside toxicity risks and limited clinical evidence (Level C), internal dosing is not recommended without qualified practitioner supervision. Self-medication internally is strongly discouraged.

Question 4

Is Calotropis gigantea safe during pregnancy?

Accepted Answer

Calotropis gigantea is unsafe during pregnancy and breastfeeding. The cardiac glycosides can cross the placenta and may cause fetal toxicity, uterine contractions, or miscarriage. The traditional purgative use also risks dangerous electrolyte disturbances in pregnant women. This herb is contraindicated in pregnancy and should be strictly avoided. Evidence Level: C (preclinical safety data).

Question 5

What are the side effects of Calotropis gigantea latex?

Accepted Answer

Calotropis gigantea latex can cause severe contact dermatitis, skin blistering, and intense local irritation upon topical application. Internal exposure leads to cardiac toxicity manifesting as arrhythmias and heart block, plus gastrointestinal symptoms including nausea, vomiting, and diarrhea. Fatal toxicity is possible at higher doses. Evidence Level: C (case reports and traditional knowledge).

Calotropis gigantea

Sources & Citations

Abutilon indicum

Jatropha curcas

Gleditsia japonica

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Drug interactions

Evidence summary

PubMed sources

Government sources