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Calotropis gigantea
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
Pan-tropical weed; latex used in Ayurveda for skin diseases, joint pain, and as purgative; cardiac glycosides.
Pan-tropical weed; latex used in Ayurveda for skin diseases, joint pain, and as purgative; cardiac glycosides. Key active compounds include calotropin, calactin, uzarigenin.
calotropin, along with calactin and uzarigenin, are the primary bioactive compounds in Calotropis gigantea. These compounds modulates NF-κB and COX-2 inflammatory pathways, disrupts microbial cell membranes and inhibits pathogen growth, acts on pain pathways via anti-inflammatory and neuroactive effects.
Anti-inflammatory
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Analgesic
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Topical antimicrobial
Laxative
Skin diseases
Based on traditional use; clinical evidence limited
Joint pain
Based on traditional use; clinical evidence limited
Toothache
Based on traditional use; clinical evidence limited
Wounds
Based on traditional use; clinical evidence limited
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