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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Abutilon indicum, also known as Atibala or Country mallow, is a perennial shrub of the Malvaceae family used in traditional medicine for its anti-inflammatory, analgesic, and antioxidant properties [PMID:37303858, PMID:36235451, PMID:20645814].
Background
Abutilon indicum is a perennial shrub found in many Asian countries, including India, Sri Lanka, and parts of Malaysia [PMID:36235451, PMID:38186405]. It is widely utilized within the Ayurveda system of medicine [PMID:37303858].
Traditional uses
Traditionally used to treat inflammation, discomfort, urethral infections, gout, bronchitis, diabetes, piles, constipation, chronic cystitis, gonorrhea, gleet, pregnancy-related problems, jaundice, and leprosy [PMID:36235451, PMID:38021797, PMID:39097211, PMID:34697741].
Active compounds
Identified constituents include alkaloids, flavonoids, sesquiterpene lactones, gallic acid, β-sitosterols, geraniol, caryophyllene, and eugenol [PMID:38186405, PMID:34697741, PMID:10798248]. Specific isolated compounds include abutilin A and (R)-N-(1'-methoxycarbonyl-2'-phenylethyl)-4-hydroxybenzamide [PMID:18636384], as well as methyl trans-p-coumarate, methyl caffeate, syringic acid, and pinellic acid [PMID:25422029].
Mechanism of action
The ethanolic leaf extract has demonstrated anti-inflammatory effects by targeting the 5-lipoxygenase enzyme [PMID:38186405]. It may also exhibit insulin-like character to inhibit lipolysis and stimulate adipogenesis activity [PMID:36684487].
Clinical evidence
Evidence DDiabetic neuropathy
A study of 33 patients receiving a decoction of Atibala-mula (10g twice daily) and Bhumyamalaki Churna (3g twice daily) for 30 days was conducted to assess sensory perception and symptoms like numbness and pain [PMID:22529650].
Evidence DInflammation
Ethanolic extract of the whole plant showed significant dose-dependent anti-inflammatory activity in Wistar albino rats, comparable to ibuprofen [PMID:21999427].
Evidence DPain (Analgesia)
Eugenol isolated from A. indicum exhibited significant inhibition of acetic acid-induced writhing in mice [PMID:10798248].
Evidence DAnxiety and Depression
Crude methanolic extract of leaves and bark exhibited anxiolytic and antidepressant potential in mice models [PMID:34697741].
Evidence DLead-induced reproductive toxicity
Methanolic root extract mitigated the toxic impact of lead on the reproductive system of male Wistar rats [PMID:30714201].
Safety & adverse effects
A study on the methanolic extract of A. indicum seed (MAS) aimed to document in-vitro cytotoxicity, mutagenicity, and in-vivo acute and sub-acute toxicity [PMID:39097211].
Pregnancy & lactation
Traditionally, A. indicum seed powder is consumed to treat pregnancy-related problems [PMID:39097211].
Evidence summary
The current evidence is primarily based on in-vitro studies, animal models (mice/rats), and a small-scale clinical observation. There is a lack of high-level clinical trials (RCTs) or systematic reviews to confirm efficacy in humans.
PubMed sources
1.PMID: 37303858 (2021) — Pharmacognostical and phytochemical studies of Atibala (Abutilon indicum [Linn.] sweet) fruit. · Ayu
2.PMID: 18636384 (2008) — Chemical constituents from Abutilon indicum. · Journal of Asian natural products research
3.PMID: 22529650 (2011) — Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy. · Ayu
4.PMID: 38021797 (2023) — Phytochemical Analysis and Antioxidant Evaluation of the Ethanolic Extract of the Leaves of Abutilon indicum. · Cureus
5.PMID: 36235451 (2022) — The Structural, Biological, and In-Silico Profiling of Novel Capryloyl Tetra-Glucoside and Aliphatic Ester Constituents from the Abutilon indicum Offers New Perspectives on the Treatment of Pain and Inflammation.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 36684487 (2023) — Effect of Abutilon indicum (L) Extract on Adipogenesis, Lipolysis and Cholesterol Esterase in 3T3-L1 Adipocyte Cell Lines. · Indian journal of clinical biochemistry : IJCB
7.PMID: 39097211 (2024) — Toxicological profiling of methanolic seed extract of Abutilon indicum (L.) Sweet: in-vitro and in-vivo analysis. · Journal of ethnopharmacology
8.PMID: 21999427 (2012) — Anti-inflammatory activity of Abutilon indicum extract. · Natural product research
9.PMID: 34697741 (2021) — Abutilon indicum Exhibits Anxiolytic and Antidepressant Effects in Mice Models. · Doklady. Biochemistry and biophysics
10.PMID: 20645814 (2010) — Antioxidant potential and radical scavenging effects of various extracts from Abutilon indicum and Abutilon muticum. · Pharmaceutical biology
11.PMID: 10798248 (2000) — Analgesic principle from Abutilon indicum. · Die Pharmazie
12.PMID: 38186405 (2023) — Evaluation of the Ethanolic Leaf Extract of Abutilon indicum on Isonicotinic Acid Hydrazide-Induced Proinflammatory Marker Gene Expression Changes. · Cureus
13.PMID: 25422029 (2015) — Cytotoxic constituents of Abutilon indicum leaves against U87MG human glioblastoma cells. · Natural product research
14.PMID: 30714201 (2019) — Protective effect of Abutilon indicum against lead-induced reproductive toxicity in male Wistar rats. · Journal of cellular biochemistry