Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Ageratum conyzoides work for wound healing?
Ageratum conyzoides promotes wound healing primarily through antimicrobial and anti-inflammatory mechanisms. Its essential oils and flavonoids inhibit bacterial growth, preventing wound infection, while chromenes reduce local inflammation and pain. Research suggests these active compounds accelerate tissue contraction and collagen deposition, facilitating faster closure of wounds. However, the presence of pyrrolizidine alkaloids limits its safety profile, making topical application the preferred method over internal use for treating injuries (Evidence Level: C/Traditional).
Does Ageratum conyzoides interact with liver medications?
Yes, Ageratum conyzoides poses significant interaction risks with liver medications due to its hepatotoxic pyrrolizidine alkaloids. Combining this herb with drugs that stress the liver, such as acetaminophen, statins, or antiretrovirals, increases the risk of liver damage or veno-occlusive disease. It may also alter the metabolism of drugs processed by cytochrome P450 enzymes. Patients taking hepatotoxic medications or those with compromised liver function should strictly avoid internal consumption of this herb (Evidence Level: D).
What is the recommended dosage for Ageratum conyzoides?
The traditional adult dosage for Ageratum conyzoides is 3 to 6 grams of dried leaf prepared as a decoction, taken internally. For external wound care or rheumatic pain, a paste made from fresh leaves is applied topically to the affected area. Due to the presence of toxic pyrrolizidine alkaloids, internal use should be restricted to short durations only. Long-term ingestion is strongly discouraged to prevent cumulative liver damage (Evidence Level: Traditional).
Is Ageratum conyzoides safe during pregnancy?
No, Ageratum conyzoides is considered unsafe during pregnancy and breastfeeding. The plant contains pyrrolizidine alkaloids, which are known hepatotoxins and potential teratogens that can cross the placental barrier. Ingestion during pregnancy may cause fetal liver damage or developmental abnormalities. Additionally, the herb may stimulate uterine contractions, increasing the risk of miscarriage. Pregnant women should avoid all forms of this herb, including topical applications on large skin areas (Evidence Level: C).
What are the side effects of Ageratum conyzoides?
The most serious side effect of Ageratum conyzoides is hepatotoxicity, specifically hepatic veno-occlusive disease, caused by its pyrrolizidine alkaloid content. Prolonged internal use can lead to abdominal swelling, jaundice, and liver cirrhosis. Topical application may cause contact dermatitis or skin irritation in sensitive individuals. Because the toxic alkaloids are excreted in breast milk, nursing mothers risk poisoning their infants. Users should immediately discontinue use if signs of liver distress appear (Evidence Level: C).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Ageratum conyzoides, also known as Billy goat weed, is an invasive annual aromatic herb distributed in tropical and subtropical regions with significant therapeutic potential [PMID:31290201, PMID:37375954].
Contexte
Ageratum conyzoides L. (Asteraceae) is an annual herbaceous plant of American origin that has naturalized globally, particularly in Tropical America, Africa, Asia, and Europe [PMID:39407602, PMID:37375954]. It is characterized by rapid growth, strong ecological adaptability, and is often considered an invasive alien species in agricultural and natural ecosystems [PMID:39407602, PMID:39463739].
Usages traditionnels
The herb has a long history of traditional medicinal use in tropical and subtropical regions [PMID:11864757]. It has been used to treat ailments including leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia, dysentery, diarrhea, and as a wound dressing, antimicrobial, and mouthwash [PMID:31290201, PMID:34069197]. It is also empirically used as an antihemorrhagic, antiseptic, and wound-healing agent [PMID:33110668].
Composés actifs
Isolated chemical compounds include alkaloids, flavonoids, chromenes, benzofurans, terpenoids, sterols, phenols, phenolic esters, and coumarins [PMID:11864757, PMID:31290201, PMID:33110668]. Essential oils from white flower chemotypes predominantly contain precocene I (80.4%) and (E)-caryophyllene (14.8%), while purple flower chemotypes contain β-acoradiene, γ-amorphene, α-pinene, bicyclogermacrene, and α-santalene [PMID:37178553].
Mécanisme d'action
Aqueous extracts of A. conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation [PMID:36907476]. It may also exert anti-inflammatory activity through the inhibition of inducible nitric oxide synthase (iNOS) [PMID:34486351]. In hair growth models, standardized extract (ACE) inhibited 5α-reductase activity, modulated ERα and ERβ signaling, and activated Wnt/β-catenin and MAPK pathways [PMID:40871645]. In wound repair, it promotes haemostasis by lowering plasma fibrinogen and enhancing platelet-derived growth factors [PMID:40820482].
Preuves cliniques
Preuve DInflammation
Aqueous extracts show anti-inflammatory activity by suppressing NLRP3 inflammasome activation [PMID:36907476] and inhibiting iNOS [PMID:34486351].
Preuve DHair Loss
Standardized extract (ACE) demonstrated trichogenic potential in human follicle dermal papilla cells and C57BL/6 mice [PMID:40871645].
Preuve CWound Healing
Promotes haemostasis by lowering plasma fibrinogen and enhancing platelet-derived growth factors [PMID:40820482].
Preuve DMosquito Larvae
Petroleum ether crude extracts showed significant larvicidal activity (92-96%) against Ae. aegypti, An. stephensi, and Cx. quinquefasciatus [PMID:33543438].
Sécurité et effets indésirables
Toxicological studies have been conducted to evaluate the safety profile for clinical development [PMID:34069197, PMID:31290201].
Synthèse des preuves
The current evidence is primarily based on review articles, in vitro studies, and animal models (Level C and D). There is a lack of human clinical trials to establish standardized dosing or clinical efficacy.
Sources PubMed
1.PMID: 11864757 (2002) — Ageratum conyzoides L. (Asteraceae). · Fitoterapia
2.PMID: 39407602 (2024) — Defense Molecules of the Invasive Plant Species Ageratum conyzoides. · Molecules (Basel, Switzerland)
3.PMID: 37375954 (2023) — Ecology, Biology, Environmental Impacts, and Management of an Agro-Environmental Weed Ageratum conyzoides. · Plants (Basel, Switzerland)
4.PMID: 31290201 (2019) — Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L. · Phytotherapy research : PTR
5.PMID: 37954507 (2023) — The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review. · Infection and drug resistance
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 33543438 (2021) — Chemical characterization of billy goat weed extracts Ageratum conyzoides (Asteraceae) and their mosquitocidal activity against three blood-sucking pests and their non-toxicity against aquatic predators. · Environmental science and pollution research international
7.PMID: 34628588 (2022) — Turning Waste into Beneficial Resource: Implication of Ageratum conyzoides L. in Sustainable Agriculture, Environment and Biopharma Sectors. · Molecular biotechnology
8.PMID: 34069197 (2021) — Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens. · Molecules (Basel, Switzerland)
9.PMID: 33365984 (2019) — The complete chloroplast genome of Ageratum conyzoides (Asteraceae). · Mitochondrial DNA. Part B, Resources
10.PMID: 11962326 (2002) — [Allelopathy of Ageratum conyzoides. VI. Effects of meteorological conditions on allelopathy of Ageratum conyzoides]. · Ying yong sheng tai xue bao = The journal of applied ecology
11.PMID: 39463739 (2024) — The influence of climate change on the potential distribution of Ageratum conyzoides in China. · Ecology and evolution
12.PMID: 37896122 (2023) — Modeling Study of the Effects of Ageratum conyzoides on the Transmission and Control of Citrus Huanglongbing. · Plants (Basel, Switzerland)
13.PMID: 36356537 (2023) — Dual tolerance of ageratum (Ageratum conyzoides L.) to combined pollution of acid and cadmium: Field survey and pot experiment. · Journal of environmental management
15.PMID: 31087887 (2019) — [Remediation Potential of Ageratum conyzoides L. on Cadmium Contaminated Farmland]. · Huan jing ke xue= Huanjing kexue
16.PMID: 40871645 (2025) — Hair Growth and Health Promoting Effects of Standardized Ageratum conyzoides Extract in Human Follicle Dermal Papilla Cells and in C57BL/6 Mice. · Nutrients
17.PMID: 37809545 (2023) — Impact of leaf trichomes of tomatoes and weeds on the host selection and developmental bioassays of Bemisia tabaci Q and A cryptic species. · Heliyon
18.PMID: 33110668 (2020) — Medicinal Effect, In Silico Bioactivity Prediction, and Pharmaceutical Formulation of Ageratum conyzoides L.: A Review. · Scientifica
19.PMID: 40820482 (2025) — African Medicinal Plants in Cutaneous Wound Repair: A Comprehensive Analysis of the Role of Phytochemicals. · International wound journal
20.PMID: 36907476 (2023) — The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation. · Journal of ethnopharmacology
21.PMID: 22001569 (2012) — Ageratum conyzoides: a host to a unique begomovirus disease complex in Cameroon. · Virus research
22.PMID: 34486351 (2021) — Potential of Ageratum conyzoides in Inhibiting Nitric Oxide Synthase. · Pakistan journal of biological sciences : PJBS