PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A standardized dried extract (900 mg/day) produced a diuretic effect stronger than a placebo and equivalent to hydrochlorothiazide (25 mg/day) without significant electrolyte changes [PMID:24723963].
Oral intake of aqueous extract stimulates the secretion of Tamm-Horsfall protein (uromodulin) in human urine [PMID:35809378].
A double-blind, randomized clinical trial was conducted to assess the antihypertensive effect of 900 mg/day of standardized dry extract compared to hydrochlorothiazide [PMID:35168030].
In streptozotocin-induced diabetic rats, horsetail extract (50-200 mg/kg) modulated insulin sensitivity and activated SIRT1 [PMID:32486051].
Extracts showed antiproliferative activity against HeLa, HT-29, and MCF7 cell lines [PMID:20170379], and total flavonoids inhibited growth of MCF-7, Caco-2, and HeLa cells [PMID:36718311].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 28275210 (2017) — Phytomedicine in Joint Disorders. · Nutrients
- 2.PMID: 35998247 (2012) — Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells. · CITED REFERENCE
- 3.PMID: 7860196 (1994) — Urolithiasis and phytotherapy. · International urology and nephrology
- 4.PMID: 38615440 (2024) — Equisetum arvense as a silica fertilizer. · Plant physiology and biochemistry : PPB
- 5.PMID: 22228296 (2012) — Equisetum arvense (Field Horsetail)-induced liver injury. · European journal of gastroenterology & hepatology