Amomum compactum (Amomum compactum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Amomum compactum work for digestion?

Amomum compactum works primarily through its volatile oils, such as cineole and borneol, which function as carminatives. These compounds help relax gastrointestinal smooth muscle, reducing spasms and expelling gas to relieve bloating. In Traditional Chinese Medicine, this mechanism is described as 'warming the middle burner' and transforming dampness to resolve digestive stagnation. This action helps stimulate appetite and alleviate nausea (Evidence Level: C/Traditional).

Is Amomum compactum safe to take during pregnancy?

Amomum compactum is generally considered unsafe during pregnancy despite its historical use for morning sickness. Regulatory guidelines often advise against its use while pregnant due to the presence of volatile oils like camphor, which may stimulate uterine contractions. While Traditional Chinese Medicine practitioners have used it for nausea, modern safety assessments recommend avoiding it unless prescribed by a qualified specialist. It should not be used while breastfeeding (Evidence Level: C).

What is the recommended dosage for Amomum compactum?

The standard adult dosage for Amomum compactum is typically 3 to 6 grams of dried fruit daily. In Traditional Chinese Medicine, the fruit is often ground into a powder or added to decoctions. Because the active medicinal compounds are volatile oils, practitioners recommend adding the herb during the last few minutes of boiling to preserve potency. Always follow specific product instructions or professional advice (Evidence Level: Traditional).

Does Amomum compactum interact with any medications?

Currently, there are no well-documented severe drug interactions associated with Amomum compactum in standard medical databases. However, because it influences gastric motility, it could theoretically alter the absorption rates of oral medications. As a warming herb, it is generally avoided when taking cooling or sedating herbal formulas. Patients taking prescription drugs should consult a qualified practitioner before use (Evidence Level: D).

What are the main benefits of Amomum compactum (Bai Dou Kou)?

Amomum compactum is primarily used to treat digestive stagnation and nausea. As a carminative, it helps relieve bloating, gas, and abdominal distension. In Traditional Chinese Medicine, it is valued for 'warming the middle burner' and transforming dampness, making it effective for symptoms like loss of appetite, morning sickness, and lethargy. It is often paired with other herbs to enhance digestive function (Evidence Level: C/Traditional).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 17 articles PubMed · modèle : gemma4:31b

Résumé

Amomum compactum, also known as Java cardamom, is a spice herb used in traditional medicine and food flavoring [PMID:37781022]. It exhibits antibacterial, antioxidant, and anti-inflammatory properties [PMID:37781022, PMID:36079603, PMID:22553068].

Contexte

Amomum compactum (Java cardamom) is a member of the Zingiberaceae family [PMID:36079603]. It is a basic species of the traditional herbal medicine amomi fructus rotundus [PMID:29449878].

Usages traditionnels

It is commonly used as a spice for flavoring food and in traditional medicine in Indonesia [PMID:37781022] and Korea [PMID:22553068]. Historically, it may have been used as baidoukou [PMID:1482527].

Composés actifs

The primary active compound of its volatile oil is 1,8-cineole (eucalyptol) [PMID:37842654, PMID:37781022]. It also contains flavonoids and phenolic compounds [PMID:36079603], as well as o-cymene and terpinen-4-ol [PMID:35342880].

Mécanisme d'action

1,8-cineole ameliorates colon injury by inhibiting the HSP90-NLRP3-SGT1 complex and downregulating macrophage M1 polarization [PMID:37842654]. Ethanolic extracts inhibit the production of NO, PGE(2), IL-6, and TNF-α by inhibiting NF-κB translocation and enhancing HO-1 expression and Nrf2 nuclear translocation [PMID:22553068]. It also demonstrates Angiotensin I-Converting Enzyme (ACE) inhibition [PMID:37781022] and α-glucosidase inhibition [PMID:35342880].

Preuves cliniques

Preuve DAllergic Asthma

Treatment markedly decreased infiltrating eosinophils, mucus hypersecretion, ROS, Th2 cytokines (IL-4, IL-5), and total IgE in a murine model [PMID:20834153]

Preuve DColitis

1,8-cineole showed remarkable anti-inflammatory effects on colitis pathogenesis in a DSS-induced mouse model [PMID:37842654]

Preuve DGastric Ulcer

A combination of hot water extracts (including A. compactum) showed gastroprotective effects against aspirin-induced gastric ulcers in rats [PMID:25183139]

Preuve DAcute Kidney Injury (AKI)

Used for treatment of gentamicin-induced AKI in rats, affecting phospholipid metabolism [PMID:27978472]

Preuve DHeart Failure

As part of Sugemule-3 decoction, it demonstrated cardioprotective effects against isoproterenol-induced heart failure in rats via regulation of mitochondrial dynamics [PMID:34600079]

Preuve DBacterial Infections (Colibacillosis)

Sécurité et effets indésirables

A polyherbal formulation containing A. compactum showed no significant toxic effects or deaths in rats at a single oral dose of 2,000 mg/kg, with an estimated LD50 > 2,000 mg/kg [PMID:32309440].

Synthèse des preuves

The current evidence is based primarily on in vitro studies and animal models (mice, rats, and chickens), indicating strong potential for anti-inflammatory, antioxidant, and antibacterial activities. There are no human clinical trials provided in the source data.

Sources PubMed

1.PMID: 37781022 (2023) — Antibacterial and Angiotensin I-Converting Enzyme (ACE) Inhibition Activities of Essential Oil from Java Cardamom (Amomum compactum) Fruit. · Indian journal of microbiology
2.PMID: 36079603 (2022) — Effects of Methods and Durations of Extraction on Total Flavonoid and Phenolic Contents and Antioxidant Activity of Java Cardamom (Amomum compactum Soland Ex Maton) Fruit. · Plants (Basel, Switzerland)
3.PMID: 33365677 (2019) — Complete chloroplast genome sequence of Amomum villosum. · Mitochondrial DNA. Part B, Resources
4.PMID: 37842654 (2023) — 1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex. · Journal of pharmaceutical analysis
5.PMID: 29449878 (2018) — Complete chloroplast genome of the medicinal plant Amomum compactum: gene organization, comparative analysis, and phylogenetic relationships within Zingiberales.

Amomum compactum

Sources et citations

Calculer une dose sûre de Amomum compactum

Mentha Spicata Var

Fo Shou

Sa Nhan

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Amomum compactum

Sources et citations

Calculer une dose sûre de Amomum compactum

Plantes associées

Mentha Spicata Var

Fo Shou

Sa Nhan

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales