Angelica dahurica (Angelica dahurica): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Angelica dahurica work for headaches and nasal congestion?

Angelica dahurica contains furanocoumarins, including byakangelicin, isoimperatorin, and phellopterin, which exhibit anti-inflammatory and analgesic properties. In Traditional Chinese Medicine, it releases the exterior and disperses wind-cold, helping open nasal passages and relieve headache pain. These compounds may reduce nasal mucosal swelling and modulate inflammatory pathways. Evidence level: C (preliminary clinical evidence). The herb also contains xanthotoxin and bergapten, which contribute to its therapeutic effects, though more research is needed to fully elucidate its mechanism of action.

Does Angelica dahurica interact with any medications?

Angelica dahurica contains furanocoumarins that may affect cytochrome P450 enzymes, potentially altering the metabolism of certain drugs. Due to its photosensitizing compounds, it may increase photosensitivity when combined with other photosensitizing medications. Caution is advised with anticoagulants or antiplatelet drugs, as some coumarin derivatives may affect blood clotting. Evidence level: C (limited clinical data). Patients taking prescription medications should consult a qualified healthcare provider before using this herb to avoid potential interactions.

What is the recommended dosage for Angelica dahurica?

The standard adult dosage for Angelica dahurica is 3-9 grams of dried root daily, typically prepared as a decoction. Standardized extracts are commonly dosed at approximately 300mg daily. In Traditional Chinese Medicine formulations, the herb is often combined with other herbs, and dosages may vary based on the specific condition being treated. Evidence level: C (preliminary clinical evidence). Always follow product labeling instructions or consult a qualified practitioner, as individual needs may vary based on health status and treatment goals.

Is Angelica dahurica safe during pregnancy?

Angelica dahurica is considered unsafe during pregnancy and should be avoided, particularly in large doses. Traditional Chinese Medicine contraindicates its use in pregnancy due to potential effects on the uterus. The herb contains compounds that may stimulate uterine contractions or affect hormonal balance. Women who are pregnant, nursing, or attempting to conceive should not use this herb without explicit guidance from a qualified healthcare provider. Evidence level: Traditional use contraindication. Always consult a healthcare professional before using herbal medicines during pregnancy.

What are the side effects of Angelica dahurica?

Common side effects of Angelica dahurica include photosensitivity due to its furanocoumarin content, which may cause skin reactions when exposed to sunlight. Gastrointestinal upset, including nausea and discomfort, has been reported in some individuals. The herb is contraindicated in cases of yin deficiency with heat signs or fire excess headache. Evidence level: C. Users should avoid prolonged sun exposure while taking this herb and discontinue use if adverse reactions occur. Consult a healthcare provider if side effects persist or worsen.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Angelica dahurica is a traditional Chinese medicinal herb known for its diverse pharmacological activities, including anti-inflammatory, analgesic, and neuroprotective effects [PMID:35847034].

Contexte

Angelica dahurica (also known as Baizhi) is an edible medicinal herb from the Apiaceae family, primarily utilized for its roots [PMID:35847034, PMID:37538857].

Usages traditionnels

It has been used in China and Korea for thousands of years to treat headaches, migraine, cold-damp pain, skin diseases, toothache, abscess, and furunculosis [PMID:35847034, PMID:37834161, PMID:35656472, PMID:42320771].

Composés actifs

The major active compounds are coumarins (such as imperatorin, isoimperatorin, oxypeucedanin, and byakangelicol) and volatile oils [PMID:35847034, PMID:36376257, PMID:41504993, PMID:41344522]. Other identified constituents include polysaccharides, alkaloids, phenols, sterols, benzofurans, polyacetylenes (e.g., falcarindiol), and polysaccharides [PMID:35847034, PMID:14751304].

Mécanisme d'action

Mechanisms include the inhibition of microglial activation and downregulation of TLR3/TLR4/MyD88/SARM1/NF-κB signaling pathways for neuroprotection [PMID:41504993], mTOR-dependent control of inflammation and oxidative stress in lung injury [PMID:41344522], and targeting the PI3K/AKT pathway to inhibit fibroblast-like synoviocyte proliferation in rheumatoid arthritis [PMID:40616331]. Polysaccharides may act via the gut microbiota-derived imidazole propionate and PPAR-γ signaling activation [PMID:40045660].

Preuves cliniques

Preuve DMigraine

Alleviates migraine by ameliorating neuroinflammation and oxidative stress, and regulating the gut microbiota-metabolome-gut-brain axis in rat models [PMID:42320771, PMID:41132525]

Preuve DInflammatory Pain

Extracts attenuated mechanical and thermal hypersensitivities in CFA-induced inflammatory pain mice models via TRPV1 [PMID:35656472]

Preuve DLiver Injury

Polysaccharides (ADP) reduced serum ALT and AST levels and alleviated oxidative stress-induced liver injury in OVX/D-Gal rats [PMID:42159294]

Preuve DBone Loss

Water extract (WEAD) suppressed osteoclast differentiation and alleviated bone loss in ovariectomized mice [PMID:37834161]

Preuve DColitis

Polysaccharides effectively alleviated DSS-induced colitis by restoring gut microbiota balance [PMID:40045660]

Preuve DIschemic Brain Injury

Byakangelicol attenuated brain infarction and neurological deficits in a photothrombotic ischemia mouse model [PMID:41504993]

Synthèse des preuves

The current evidence is primarily based on preclinical studies (animal models and in vitro assays) and reviews, indicating a low overall level of clinical evidence (Level D).

Sources PubMed

1.PMID: 34451622 (2021) — Oxypeucedanin: Chemotaxonomy, Isolation, and Bioactivities. · Plants (Basel, Switzerland)
2.PMID: 35847034 (2022) — The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology. · Frontiers in pharmacology
3.PMID: 37538857 (2023) — Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica. · Chinese herbal medicines
4.PMID: 42159294 (2026) — Protective effects of Angelica dahurica polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats. · Redox report : communications in free radical research
5.PMID: 41504993 (2026) — Byakangelicol Alleviates Ischemic Brain Injury by Inhibiting Microglial Activation and Oxidative Stress. · Molecular neurobiology

Angelica dahurica

Sources et citations

Calculer une dose sûre de Angelica dahurica

Clerodendrum Myricoides

Kunzea Ambigua

Ligusticum sinense

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Angelica dahurica

Sources et citations

Calculer une dose sûre de Angelica dahurica

Plantes associées

Clerodendrum Myricoides

Kunzea Ambigua

Ligusticum sinense

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales