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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Aristolochia debilis
Liane grimpante d'Asie de l'Est utilisée en médecine traditionnelle chinoise comme Ma Dou Ling pour les affections respiratoires; contient des acides aristolochiques néphrotoxiques.
Aristolochia debilis, known in Traditional Chinese Medicine as Ma Dou Ling, is a climbing vine historically used for respiratory conditions such as cough and asthma. Its primary active compounds, aristolochic acid I and II, are potent nephrotoxins and carcinogens, leading to severe restrictions or bans in many countries. Due to its high toxicity, clinical use is contraindicated, and the herb is primarily of historical and toxicological interest.
Aristolochic acids (AAs) undergo metabolic activation by nitroreductases to form cyclic nitrenium ions that covalently bind to DNA, primarily at adenine residues, creating aristolactam-DNA adducts. These adducts cause characteristic A→T transversions in the TP53 tumor suppressor gene, driving urothelial carcinogenesis. Additionally, AAs induce proximal tubular epithelial cell apoptosis and interstitial fibrosis via mitochondrial dysfunction and activation of TGF-β1 signaling, leading to progressive renal failure. The herb also contains aristolochic alkaloids that may contribute to additional toxic effects.
Liane grimpante d'Asie de l'Est utilisée en médecine traditionnelle chinoise comme Ma Dou Ling pour les affections respiratoires; contient des acides aristolochiques néphrotoxiques.
Aristolochia debilis, known in Traditional Chinese Medicine as Ma Dou Ling, is a climbing vine historically used for respiratory conditions such as cough and asthma. Its primary active compounds, aristolochic acid I and II, are potent nephrotoxins and carcinogens, leading to severe restrictions or bans in many countries. Due to its high toxicity, clinical use is contraindicated, and the herb is primarily of historical and toxicological interest.
Aristolochic acids (AAs) undergo metabolic activation by nitroreductases to form cyclic nitrenium ions that covalently bind to DNA, primarily at adenine residues, creating aristolactam-DNA adducts. These adducts cause characteristic A→T transversions in the TP53 tumor suppressor gene, driving urothelial carcinogenesis. Additionally, AAs induce proximal tubular epithelial cell apoptosis and interstitial fibrosis via mitochondrial dysfunction and activation of TGF-β1 signaling, leading to progressive renal failure. The herb also contains aristolochic alkaloids that may contribute to additional toxic effects.