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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
AR
NervineVérifié
Asteraceae Roman Chamomile
Chamaemelum nobile
remède contre l'anxiété et l'insomnie en phytothérapie européenne
Roman chamomile produces its anxiolytic effects primarily through flavonoids like apigenin, which bind to benzodiazepine receptors on GABA-A receptors in the brain, enhancing inhibitory neurotransmission and promoting relaxation. The volatile compounds chamazulene and alpha-bisabolol contribute additional calming and anti-inflammatory activity. Antispasmodic effects occur via calcium channel blockade in smooth muscle. These mechanisms support its traditional use for anxiety, though clinical evidence remains preliminary (Evidence level: B).
Does Roman chamomile interact with any medications?
Roman chamomile may potentiate the effects of central nervous system depressants, including benzodiazepines, barbiturates, and alcohol, due to its sedative properties. Theoretical interactions exist with anticoagulants and antiplatelet medications, though clinical evidence is limited. Patients taking blood thinners, sedatives, or scheduled for surgery should consult a healthcare provider before use. Those on diabetes medications should monitor blood glucose, as hypoglycemic effects have been reported in animal studies (Evidence level: B for sedative interactions; C for others).
What is the recommended dosage for Roman chamomile tea?
The standard adult dosage for Roman chamomile is 2-4 grams of dried flowers steeped as tea, taken up to three times daily. For aromatherapy applications, the essential oil should be diluted to 1-3% concentration in a carrier oil before topical use. Internal use of the essential oil is not recommended without professional supervision. Pediatric dosing has not been well established. Start with lower doses to assess individual tolerance and consult a qualified herbalist for personalized guidance (Evidence level: Traditional).
Is Roman chamomile safe to use during pregnancy?
Roman chamomile is considered unsafe during pregnancy due to its emmenagogue properties, which may stimulate uterine contractions and potentially induce menstruation or miscarriage. Pregnant women should avoid both internal consumption and concentrated essential oil preparations. Limited safety data exists for breastfeeding women, so caution is advised. Those planning pregnancy should discontinue use. Always consult a qualified healthcare provider before using herbal remedies during pregnancy (Evidence level: Traditional/C).
Can Roman chamomile help with sleep and insomnia?
Roman chamomile has been used traditionally in European herbalism as a gentle sedative for insomnia and sleep disturbances. Preliminary research suggests it may improve sleep quality and reduce sleep onset time through GABAergic activity, though robust clinical trials are limited (Evidence level: B). Tea preparations taken 30-60 minutes before bedtime are commonly recommended. Roman chamomile is often combined with other sedative herbs such as valerian or passionflower for enhanced sleep-supporting effects.
Who should avoid using Roman chamomile?
Individuals with known allergies to plants in the Asteraceae family (ragweed, marigolds, daisies, chrysanthemums) should avoid Roman chamomile due to potential cross-reactivity and allergic contact dermatitis. Pregnant women should not use it due to uterine stimulant effects. Those taking CNS depressants or anticoagulants should exercise caution. Rare allergic reactions, including skin rashes and respiratory symptoms, have been reported. Discontinue use if any adverse reactions occur and seek medical advice (Evidence level: B for allergy risk).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 28 articles PubMed · modèle : gemma4:31b
Résumé
Roman chamomile (Chamaemelum nobile) is a perennial herb of the Asteraceae family used traditionally for its anti-inflammatory, sedative, and antimicrobial properties [PMID:36615326, 40006854].
Contexte
Chamaemelum nobile, also known as Roman chamomile, is a medicinal plant widely cultivated across Europe, Northwest Asia, North America, and Africa [PMID:38540360]. It is one of two primary chamomile species used therapeutically, alongside German chamomile (Matricaria chamomilla) [PMID:36297396].
Usages traditionnels
It has been used for thousands of years in Greece, Rome, and ancient Egypt to treat stomach problems, cramps, dermatitis, and minor infections [PMID:36615326]. It is used orally as a sedative and for gastrointestinal conditions, topically for wound healing, and in some regions for ophthalmological problems [PMID:30000867, 27269391]. It has also been used as a galactogogue and in culinary applications [PMID:30000867, 33683253].
Composés actifs
The plant contains flavonoids, coumarins, volatile oils, terpenes, organic acids, and polysaccharides [PMID:36615326]. Specific constituents include sesquiterpenes (e.g., bisabolol, farnesene), sesquiterpene lactones (e.g., nobilin), and esters such as 3-methylpentyl angelate [PMID:30000867, 40006854, 36076410].
Mécanisme d'action
Anti-inflammatory effects may involve increasing NAG-1 activity and inhibiting ROS generation [PMID:24471493]. In anxiety treatment, it may act via multi-target pathways including neuroactive ligand-receptor interaction, serotonin synapse, and cAMP signaling, potentially involving the LRRK2 protein [PMID:33152801]. It also demonstrates in vitro vasorelaxant effects on rat aortic rings [PMID:22866985].
Preuves cliniques
Preuve DWound Infection (P. aeruginosa)
A 5% C. nobile ointment showed antimicrobial and wound healing properties in male rats [PMID:28034365].
Preuve DBronchial Inflammation
Aqueous extracts in OVA-sensitized rats improved MDA levels and reduced IL-4 and inflammatory cell infiltration [PMID:37807304].
Inhalation of Roman chamomile essential oil combined with clomipramine attenuated depression-like behavior in stressed mice [PMID:31369988].
Sécurité et effets indésirables
Roman chamomile is suspected of being a potential sensitizer that can elicit allergic plant contact dermatitis, although evidence for this specific species is largely anecdotal [PMID:12492516].
Grossesse et allaitement
It has been used as a galactogogue, but no scientifically valid clinical trials support this use [PMID:30000867].
Synthèse des preuves
The current evidence consists primarily of in vitro studies, animal models, and literature reviews; there is a lack of high-level clinical trial data (Level A or B) specifically for Roman chamomile.
Sources PubMed
1.PMID: 36615326 (2022) — Chamomile: A Review of Its Traditional Uses, Chemical Constituents, Pharmacological Activities and Quality Control Studies. · Molecules (Basel, Switzerland)
2.PMID: 36297396 (2022) — A Comprehensive Study of Therapeutic Applications of Chamomile. · Pharmaceuticals (Basel, Switzerland)
3.PMID: 30000867 (2006) — Chamomile: A herbal medicine of the past with bright future. · Molecular medicine reports
4.PMID: 36076410 (2022) — Valorisation of Roman chamomile (Chamaemelum nobile L.) herb by comprehensive evaluation of hydrodistilled aroma and residual non-volatile fractions. · Food research international (Ottawa, Ont.)
5.PMID: 38540360 (2024) — High-Quality Assembly and Analysis of the Complete Mitogenomes of German Chamomile (Matricaria recutita) and Roman Chamomile (Chamaemelum nobile).
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 28034365 (2018) — In vivo Antibacterial and Wound Healing Activities of Roman Chamomile (Chamaemelum nobile). · Infectious disorders drug targets
7.PMID: 31706023 (2020) — Analysis of terpenoid biosynthesis pathways in German chamomile (Matricaria recutita) and Roman chamomile (Chamaemelum nobile) based on co-expression networks. · Genomics
8.PMID: 35937529 (2022) — Intergeneric hybridization of marguerite (Argyranthemum frutescens (L.) Sch. Bip.) and Roman chamomile (Chamaemelum nobile (L.) All.) using ovule culture and confirmation of hybridity. · Plant biotechnology (Tokyo, Japan)
10.PMID: 37807304 (2023) — In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria). · Cellular and molecular biology (Noisy-le-Grand, France)
11.PMID: 24471493 (2014) — Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder. · Journal of natural products
12.PMID: 32070270 (2020) — Phytochemical and comparative transcriptome analyses reveal different regulatory mechanisms in the terpenoid biosynthesis pathways between Matricaria recutita L. and Chamaemelum nobile L. · BMC genomics
13.PMID: 28228817 (2016) — Mitochondrial Apoptosis Induced by Chamaemelum Nobile Extract in Breast Cancer Cells. · Iranian journal of pharmaceutical research : IJPR
14.PMID: 30430213 (2019) — De novo assembly and comparative transcriptome analysis: novel insights into terpenoid biosynthesis in Chamaemelum nobile L. · Plant cell reports
15.PMID: 38267710 (2024) — Laboratory assessment of the acaricidal, repellent and anti-cholinesterase effects of Melaleuca alternifolia and Chamaemelum nobile essential oils against Hyalomma scupense ticks. · Veterinary research communications
16.PMID: 40006854 (2025) — Phytochemical Investigation of Chamaemelum nobile L. and Evaluation of Acetylcholinesterase and Tyrosinase Inhibitory Activity. · Plants (Basel, Switzerland)
17.PMID: 33246119 (2021) — Effects of Salvia officinalis L. and Chamaemelum nobile (L.) extracts on inflammatory responses in two models of human cells: Primary subcutaneous adipocytes and neuroblastoma cell line (SK-N-SH). · Journal of ethnopharmacology
18.PMID: 27005600 (2016) — Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. · Molecules (Basel, Switzerland)
19.PMID: 26312934 (2015) — Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa. · Revista da Sociedade Brasileira de Medicina Tropical
20.PMID: 12492516 (2002) — Contact sensitization from Compositae-containing herbal remedies and cosmetics. · Contact dermatitis
21.PMID: 41204638 (2025) — Impact of Solar Drying Techniques on Bioactive Composition and Antibacterial Activity of Chamomile (Chamaemelum nobile L.). · Journal of food science
22.PMID: 37107083 (2023) — Phytochemistry and Biological Activities of Essential Oils from Six Aromatic Medicinal Plants with Cosmetic Properties. · Antibiotics (Basel, Switzerland)
23.PMID: 33683253 (2021) — Traditional plants from Asteraceae family as potential candidates for functional food industry. · Food & function
24.PMID: 27269391 (2016) — Medicinal plants used for ophthalmological problems in Navarra (Spain). · Journal of ethnopharmacology
25.PMID: 33152801 (2021) — Action mechanism of Roman chamomile in the treatment of anxiety disorder based on network pharmacology. · Journal of food biochemistry
26.PMID: 31369988 (2019) — Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
27.PMID: 22866985 (2013) — Vascular effects of aqueous extract of Chamaemelum nobile: in vitro pharmacological studies in rats. · Clinical and experimental hypertension (New York, N.Y. : 1993)