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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Blue Cohosh contains caulosaponin and related glycosides that stimulate uterine smooth muscle contractions through direct uterotonic activity. The herb also contains taspine and baptifoline, which contribute to its physiological effects on the reproductive system. These compounds appear to act on uterine receptors to increase contractility, similar to oxytocin mechanisms. Evidence level: C. The plant has centuries of traditional use as a uterine stimulant among Native American tribes including the Penobscot and Ojibwe peoples.
Is Blue Cohosh safe to take during pregnancy?
Blue Cohosh is considered unsafe during pregnancy except at term under strict medical supervision. The herb contains potent uterine stimulant compounds that can cause fetal distress, premature labor, and potential miscarriage earlier in pregnancy. Case reports have associated Blue Cohosh use with serious fetal complications including heart arrhythmias. Women with heart disease or cardiovascular conditions should avoid this herb entirely. Evidence level: C. Professional guidance is essential before any therapeutic use.
Does Blue Cohosh interact with any medications?
Blue Cohosh may interact with cardiovascular medications due to its potential to affect heart rhythm and blood pressure. The herb contains compounds that produce nicotinic-like effects, which may amplify or interfere with antihypertensive drugs, antiarrhythmic medications, and other heart medicines. Blue Cohosh should never be combined with pharmaceutical uterine stimulants such as oxytocin or prostaglandin preparations. Evidence level: C. Always consult a qualified healthcare provider before combining with prescription medications.
What is the recommended dosage for Blue Cohosh root?
The typical adult dosage for Blue Cohosh is 1-2ml of tincture or approximately 1 gram of dried root prepared as a tea. This herb should only be used at term pregnancy and exclusively under qualified medical supervision. Dosage recommendations are based on traditional use and expert consensus rather than controlled clinical trials. Evidence level: C. Self-medication with Blue Cohosh is strongly discouraged due to significant safety concerns and potential for serious adverse effects.
What are the side effects of taking Blue Cohosh?
Blue Cohosh can cause significant side effects including nicotinic-like toxicity symptoms such as nausea, vomiting, headache, and dizziness. More serious adverse effects include heart arrhythmias, elevated blood pressure, and cardiovascular distress. Fetal distress and newborn toxicity have been reported when used during pregnancy. The glycoside compounds may cause severe reactions in individuals with pre-existing heart conditions. Evidence level: C. Due to these risks, Blue Cohosh should only be used under qualified healthcare supervision.
What is Blue Cohosh used for in herbal medicine?
Blue Cohosh has been used traditionally by Native American tribes including the Penobscot and Ojibwe to facilitate labor at term and address menstrual disorders. Contemporary herbal applications include stimulating labor, treating menstrual cramps, and managing menstrual irregularities. The herb functions primarily as a uterotonic agent. Evidence level: C. Clinical research is limited, and therapeutic use remains controversial due to documented safety concerns. Professional supervision is required for any application.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 26 articles PubMed · modèle : gemma4:31b
Résumé
Blue cohosh (Caulophyllum thalictroides) is a medicinal herb used traditionally to promote labor and treat menstrual or inflammatory conditions [PMID:30000839, PMID:22988475].
Contexte
Blue cohosh is a botanical native to eastern North America, with roots and rhizomes used in traditional and Native American medicine [PMID:22988475, PMID:18376582, PMID:23420136].
Usages traditionnels
Traditionally used for the treatment of menopausal symptoms, rheumatic pain, menstrual disturbances, and as an anti-inflammatory remedy and aid in childbirth [PMID:22988475, PMID:18048069, PMID:12597249].
Composés actifs
Primary constituents include alkaloids (such as N-methylcytisine, magnoflorine, baptifoline, anagyrine, and lupanine) and triterpene saponins (including caulosaponins and various caulosides) [PMID:30000839, PMID:23420136, PMID:21872415, PMID:10543898].
Mécanisme d'action
Saponins are considered responsible for uterine-stimulating effects [PMID:18376582, PMID:12597249]. N-methylcytisine exhibits nicotine-like effects [PMID:30000839]. In vitro studies show it can suppress the expression of iNOS and proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in microglia cells [PMID:22988475].
Preuves cliniques
Preuve DLabor Induction
Used by approximately 64% of surveyed US midwives as a labor-inducing aid, though evidence for safety and efficacy is largely anecdotal [PMID:18204101, PMID:17467597].
Preuve DInflammation
Suppressed LPS-induced iNOS and proinflammatory cytokines in microglia cells and suppressed COX-2 and iNOS in adrenal glands in an in vitro model [PMID:22988475].
Sécurité et effets indésirables
Toxicity includes severe gastrointestinal and cardiovascular effects [PMID:30000839]. Nicotinic toxicity (tachycardia, diaphoresis, abdominal pain, vomiting, and muscle weakness) has been reported following use as an abortifacient [PMID:12136970]. Methanol extracts have demonstrated mitochondriotoxic activity, disrupting cellular respiration and mitochondrial membrane potential [PMID:24328138].
Grossesse et allaitement
Strongly recommended against during breastfeeding due to potential toxicity to neonates [PMID:30000839]. Maternal use to stimulate labor is associated with severe neonatal outcomes, including perinatal stroke, acute myocardial infarction, profound congestive heart failure, shock, and multi-organ hypoxic injury [PMID:18204101, PMID:9544922, PMID:24328138]. N-methylcytisine has shown teratogenic activity in rat embryo cultures [PMID:10543898].
Interactions médicamenteuses
The alkaloidal fraction of blue cohosh showed strong in vitro inhibition of cytochrome P450 enzymes CYP 2C19, 3A4, 2D6, and 1A2 [PMID:19137500].
Synthèse des preuves
Evidence is primarily based on in vitro studies, case reports, and systematic reviews of literature; there is a lack of clinical trial data, and significant safety concerns exist regarding neonatal and cardiovascular toxicity.
Sources PubMed
1.PMID: 30000839 (2006) — Adverse effects of herbal medicines: an overview of systematic reviews. · Clinical medicine (London, England)
2.PMID: 18204101 (2008) — Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation. · The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique
3.PMID: 22988475 (2012) — Anti-Inflammatory Effect of Triterpene Saponins Isolated from Blue Cohosh (Caulophyllum thalictroides). · Evidence-based complementary and alternative medicine : eCAM
4.PMID: 18376582 (2008) — Alkaloids and saponins in dietary supplements of blue cohosh (Caulophyllum thalictroides). · Journal of AOAC International
5.PMID: 23420136 (2013) — Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 12136970 (2002) — Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient. · Veterinary and human toxicology
7.PMID: 19137500 (2009) — Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay. · Planta medica
8.PMID: 21872415 (2011) — Analytical methods for determination of magnoflorine and saponins from roots of Caulophyllum thalictroides (L.) Michx. using UPLC, HPLC and HPTLC. · Journal of pharmaceutical and biomedical analysis
9.PMID: 18048069 (2008) — Alkaloids and saponins from blue cohosh. · Phytochemistry
10.PMID: 24328138 (2014) — Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. · Journal of natural products
11.PMID: 17467597 (2007) — Induction of labor with homeopathy: a case report. · Journal of midwifery & women's health
12.PMID: 12597249 (2003) — Determination of saponins and alkaloids in Caulophyllum thalictroides (blue cohosh) by high-performance liquid chromatography and evaporative light scattering detection. · Phytochemical analysis : PCA
13.PMID: 10543898 (1999) — Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture. · Journal of natural products
14.PMID: 9544922 (1998) — Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. · The Journal of pediatrics