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BL
Not CommonGénéré par IA
Boldo Leaf
Peumus boldus
Troubles du foie et de la vésicule biliaire dans la médecine sud-américaine
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Boldo (Peumus boldus M.) is a medicinal plant endemic to Chile, primarily recognized for its antioxidant, anti-inflammatory, and hepatoprotective properties [PMID:39765896, PMID:38234264].
Contexte
Peumus boldus is an endemic Chilean tree whose leaves are rich in bioactive compounds and are used as a herbal remedy in various pharmacopoeias [PMID:39765896, PMID:8202440].
Usages traditionnels
Traditionally employed in folk medicine to treat gastrointestinal disorders, liver ailments, rheumatic symptoms, headache, and urinary tract inflammation [PMID:29080449, PMID:8202440, PMID:34500293].
Composés actifs
The leaves contain aporphine alkaloids (most notably boldine, though composition varies by tree) [PMID:16221469, PMID:29454020], phenolic compounds including catechin, proanthocyanidins, and flavonol glycosides (such as quercetin and kaempferol derivatives) [PMID:12747739, PMID:20022332, PMID:24853276]. Essential oils contain 1,8-cineole, p-cymene, limonene, and ascaridole [PMID:30832296].
Mécanisme d'action
Boldine acts as a potent free radical scavenger and antioxidant [PMID:16221469, PMID:37462836]. It may induce endothelium-dependent vasodilation via nitric oxide and small-conductance Ca2+-activated K+ channels [PMID:35222671]. In neurological contexts, it may block connexin-43 hemichannels and pannexin 1 channels, and suppress AChE and BuChE activity [PMID:37462836, PMID:41353162].
Preuves cliniques
Preuve DHepatotoxicity
A case of probable boldo-induced hepatotoxicity resulting in unexplained jaundice and increased liver enzymes in an 87-year-old man, which resolved upon cessation of use [PMID:33457373]
Preuve DRenal Transplant (Drug Interaction)
A case report of subtherapeutic tacrolimus levels in a renal transplant patient while taking boldo [PMID:24981811]
Preuve DChronic Epilepsy (Murine Model)
Pulverized Boldo leaves reduced seizures, neuroinflammation, and hemichannel activity [PMID:41353162]
Preuve DDysferlinopathy (Murine Model)
Daily oral administration of pulverized leaves improved grip strength, restored endothelial-dependent vasodilation, and reduced skeletal muscle inflammation and lipid accumulation [PMID:41155239]
Preuve DH. pylori (In vitro)
Aqueous extract and catechin-derived proanthocyanidins inhibited H. pylori urease and adherence to gastric cells [PMID:24853276]
Preuve D
Sécurité et effets indésirables
Boldo leaf infusions may be hepatotoxic and cause unexplained jaundice or abnormal liver enzyme values, particularly in elderly patients [PMID:33457373].
Interactions médicamenteuses
A case report indicates a potential interaction with tacrolimus, leading to subtherapeutic drug levels in a renal transplant patient [PMID:24981811].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (mice, Drosophila), and isolated case reports. There are no RCTs or systematic reviews provided; therefore, the overall strength of clinical evidence is low.
Sources PubMed
1.PMID: 39765896 (2024) — Bioactive Content and Antioxidant Properties of Spray-Dried Microencapsulates of Peumus boldus M. Leaf Extracts. · Antioxidants (Basel, Switzerland)
2.PMID: 41353162 (2025) — Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy. · Biological research
3.PMID: 33457373 (2020) — Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. · European journal of case reports in internal medicine
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Boldo leaf infusion and ethanolic extract reduced lipoperoxidation and cytotoxicity in normal liver cells without affecting anticancer potential in cancer cells [PMID:19145575, PMID:25292342]
Preuve DObesity/Adipocytes (In vitro)
Aqueous extract inhibited lipid accumulation (triglycerides and cholesterol) and decreased ROS production in 3T3-L1 adipocytes [PMID:40362563]
— Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver.
· Phytotherapy research : PTR
6.PMID: 40362563 (2025) — Peumus boldus Extract Inhibits Lipid Accumulation in 3T3-L1 Adipocytes. · International journal of molecular sciences
7.PMID: 24981811 (2014) — Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. · Transplantation proceedings
8.PMID: 12747739 (2003) — Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo"). · Free radical research
9.PMID: 29454020 (2018) — Variation of the alkaloid content of Peumus boldus (boldo). · Fitoterapia
10.PMID: 27350578 (2016) — Peumus boldus (Boldo) Aqueous Extract Present Better Protective Effect than Boldine Against Manganese-Induced Toxicity in D. melanogaster. · Neurochemical research
11.PMID: 38234264 (2024) — Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential. · Journal of complementary & integrative medicine
12.PMID: 24853276 (2014) — Catechin-based procyanidins from Peumus boldus Mol. aqueous extract inhibit Helicobacter pylori urease and adherence to adenocarcinoma gastric cells. · Phytotherapy research : PTR
13.PMID: 8202440 (1994) — Boldo and boldine: an emerging case of natural drug development. · Pharmacological research
14.PMID: 41155239 (2025) — Boldo Restores Vascularization and Reduces Skeletal Muscle Inflammation in Symptomatic Mice with Dysferlinopathy. · International journal of molecular sciences
15.PMID: 20022332 (2010) — Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. · Journal of chromatography. A
16.PMID: 25292342 (2014) — Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro. · Journal of integrative medicine
17.PMID: 34500293 (2022) — Biochemical characterization of Peumus boldus fruits: Insights of its antioxidant properties through a theoretical approach. · Food chemistry
18.PMID: 16221469 (2006) — Boldine and its antioxidant or health-promoting properties. · Chemico-biological interactions
19.PMID: 33234091 (2021) — Ethnopharmacology, Phytochemistry and Biological Activities of Native Chilean Plants. · Current pharmaceutical design
20.PMID: 32069868 (2020) — Green Extraction of Alkaloids and Polyphenols from Peumus boldus Leaves with Natural Deep Eutectic Solvents and Profiling by HPLC-PDA-IT-MS/MS and HPLC-QTOF-MS/MS. · Plants (Basel, Switzerland)
21.PMID: 30963968 (2019) — Phytochemical Analysis and Evaluation of Antimicrobial Activity of Peumus boldus, Psidium guajava, Vernonia polysphaera, Persea Americana, Eucalyptus citriodora Leaf Extracts and Jatropha multifida Raw Sap. · Current pharmaceutical biotechnology
22.PMID: 37462836 (2023) — An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders. · Neurochemical research
23.PMID: 30832296 (2019) — Exploring the Insecticidal Potential of Boldo (Peumus boldus) Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean Daphnia magna. · Molecules (Basel, Switzerland)
24.PMID: 35222671 (2022) — Boldine, an Alkaloid from Peumus boldus Molina, Induces Endothelium-Dependent Vasodilation in the Perfused Rat Kidney: Involvement of Nitric Oxide and Small-Conductance Ca2+-Activated K+ Channel. · Evidence-based complementary and alternative medicine : eCAM
25.PMID: 33172081 (2020) — Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts. · Antibiotics (Basel, Switzerland)