Calendula arvensis (Calendula arvensis): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Calendula arvensis work to heal wounds?

Calendula arvensis promotes wound healing through its triterpenoids and flavonoids, which exhibit anti-inflammatory and antimicrobial properties. These compounds help reduce inflammation, support tissue regeneration, and may accelerate epithelialization. The carotenoids contribute antioxidant activity that protects healing tissue from oxidative damage. Evidence level B supports these wound-healing effects, though research is less extensive than for Calendula officinalis.

Does Calendula arvensis interact with any medications?

There are no well-documented drug interactions for Calendula arvensis specifically. However, due to its traditional use and similarity to Calendula officinalis, caution is advised when using it with sedatives or blood pressure medications, as theoretical interactions may exist. Always consult a healthcare provider before combining herbal remedies with prescription medications. More clinical research is needed to establish definitive interaction profiles.

What is the recommended dosage for Calendula arvensis?

The typical adult dosage for Calendula arvensis is 2-4 grams of dried flowers prepared as a tea, taken up to three times daily. For topical use, apply a cream or ointment containing Calendula arvensis extract to the affected area 2-3 times daily. Dosage recommendations are based on traditional use and extrapolation from Calendula officinalis studies, as specific clinical trials for C. arvensis are limited.

Is Calendula arvensis safe to use during pregnancy?

Calendula arvensis is considered unsafe during pregnancy, particularly in high doses. Traditional use and pharmacological evidence suggest it may stimulate uterine contractions and potentially affect pregnancy outcomes. Pregnant women should avoid both internal and high-dose topical use of this herb. Those trying to conceive should also exercise caution. Consult a qualified healthcare practitioner before using any herbal remedies during pregnancy.

What is Calendula arvensis used for medicinally?

Calendula arvensis is used in Mediterranean folk medicine primarily for wound healing and skin conditions such as minor cuts, scrapes, and inflammation. Its anti-inflammatory and antimicrobial properties make it valuable for supporting skin repair and soothing irritated tissue. While similar to common calendula (C. officinalis), C. arvensis is considered milder in its effects. Evidence level B supports its traditional wound-healing applications.

What are the side effects of Calendula arvensis?

The primary side effect of Calendula arvensis is allergic skin reactions, particularly in individuals sensitive to plants in the Asteraceae family. Those with ragweed allergy should avoid this herb due to potential cross-reactivity. Internal use may cause mild gastrointestinal upset in some individuals. Discontinue use if rash, itching, or other allergic symptoms develop. Topical preparations are generally well-tolerated when applied to intact skin.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 26 articles PubMed · modèle : gemma4:31b

Résumé

Calendula arvensis L. (field marigold) is a Mediterranean medicinal plant used traditionally for inflammatory diseases and noted for its diverse bioactivities, including anti-inflammatory and antimicrobial properties [PMID:36636465].

Contexte

Calendula arvensis L., belonging to the Asteraceae family, is an ornamental and medicinal plant widely distributed in the southern region of Europe and Mediterranean countries [PMID:36636465]. It is also considered an alimurgic plant, with its flowers and leaves used in local food dishes [PMID:35159399].

Usages traditionnels

It is used in traditional folk medicine for the treatment of many inflammatory-related diseases [PMID:40381088, PMID:36636465, PMID:30756331].

Composés actifs

The plant contains phenols, flavonoids [PMID:30756331], triterpene saponins and flavonol glycosides (particularly in florets) [PMID:35159399, PMID:36615392], and sesquiterpene glycosides [PMID:8277320]. Chloroform extracts have shown major constituents including germanicol (10.25%), arachidonic acid (8.17%), hexadecanoic acid (6.94%), 17-octadecynoic acid (5.99%), syringic acid (5.22%), and p-coumaric acid (3.04%) [PMID:40761059]. Essential oils contain zingiberenol 1, eremoligenol, beta-curcumene, zingiberenol 2, and (E,Z)-farnesol [PMID:28109063].

Mécanisme d'action

In wound-healing, it is associated with the role of transforming growth factor-beta1 (TGF-beta1), inflammatory, and biochemical molecules [PMID:40381088]. In breast cancer cell lines, ethyl acetate extracts of flowers induced apoptosis by downregulating Bcl-2 and upregulating Bax and caspase 3/7 activity [PMID:30756331].

Preuves cliniques

Preuve DExcisional neck injury (rats)

Methanolic extracts of aerial parts (MECAA) accelerated wound-healing in vivo [PMID:40381088].

Preuve BSurgical wounds (caesarean section)

A mixture of oily extracts of Hypericum perforatum and Calendula arvensis was evaluated for tissue regenerating action [PMID:11482776].

Preuve DBreast cancer (in vitro)

Ethyl acetate extract of flowers showed cytotoxic activity against MCF-7 and MDA-MB-231 cells and inhibited cell migration [PMID:30756331].

Preuve DEnterococcus faecalis (in vitro)

A 10% extract demonstrated antibacterial efficacy, showing a high zone of inhibition [PMID:33223650].

Preuve DViral infection (in vitro)

Triterpenoid and sesquiterpene glycosides inhibited vesicular stomatitis virus (VSV) multiplication; some affected rhinovirus (HRV) replication [PMID:1654576, PMID:1965654].

Sécurité et effets indésirables

In rat models, no toxicity or mortality was observed with oral supplementation of MECAA up to 5 g/kg [PMID:40381088]. Saponins in the plant have been noted to confer a haemolytic property [PMID:2332827].

Synthèse des preuves

The evidence is primarily based on in vitro studies (cell lines, antibacterial assays) and animal models (rats), with one clinical trial mentioned regarding surgical wound reconstruction. Most pharmacological claims are currently at the preclinical stage.

Sources PubMed

1.PMID: 40381088 (2025) — Field Marigold (Calendula arvensis L.) accelerates wound-healing in vivo: role of transforming growth factor-beta1 (TGF-β1), inflammatory, and biochemical molecules. · Journal of molecular histology
2.PMID: 36636465 (2023) — Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review. · Advances in pharmacological and pharmaceutical sciences
3.PMID: 35159399 (2022) — Calendula arvensis (Vaill.) L.: A Systematic Plant Analysis of the Polar Extracts from Its Organs by UHPLC-HRMS. · Foods (Basel, Switzerland)
4.PMID: 8277320 (1993) — Sesquiterpene glycosides from Calendula arvensis. · Journal of natural products
5.PMID: 30756331 (2019) — Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines.

Calendula arvensis

Sources et citations

Calculer une dose sûre de Calendula arvensis

Calendula

Arnica

Witch Hazel

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Calendula arvensis

Sources et citations

Calculer une dose sûre de Calendula arvensis

Plantes associées

Calendula

Arnica

Witch Hazel

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales